About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Car2n
null
MGI:2135646
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Car2n/Car2n involves: C57BL/6J * DBA/2J MGI:2175729
hm2
Car2n/Car2n involves: DBA/2J MGI:3783408
cx3
Car2n/Car2n
Car7tm1.1Kkai/Car7tm1.1Kkai
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J MGI:5543611
cx4
Car2n/Car2n
Car9tm1Spas/Car9tm1Spas
involves: C57BL/6J * DBA/2J MGI:3784571
cx5
Car2n/Car2n
Car9tm1Spas/Car9+
involves: C57BL/6J * DBA/2J MGI:3784572


Genotype
MGI:2175729
hm1
Allelic
Composition
Car2n/Car2n
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car2n mutation (1 available); any Car2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Morphological changes in the stomach and intestine of Car2n/Car2n and Car9tm1Spas/Car9tm1Spas mice

renal/urinary system
• urine has a more alkaline pH than wild-type when given tap water to drink

respiratory system
• respiratory acidosis

growth/size/body
• 13% of mutants exhibit gastric cysts
• smaller than controls starting not later than at 2 weeks of age

homeostasis/metabolism
• urine has a more alkaline pH than wild-type when given tap water to drink
• respiratory acidosis

skeleton
N
• the prominent osteopetrosis found in humans with carbonic anhydrase II deficiency syndrome could not be detected in mice aged up to 15 months

digestive/alimentary system
• some mutants exhibit intraepithelial lymphocytes in the duodenum
• 50% of mutants exhibit mild gastric pit-cell hyperplasia
• 13% of mutants exhibit gastric cysts
• bicarbonate secretory response of the duodenum to prostaglandin E2 (PGE2) is completely absent in mutants, however basal duodenal bicarbonate secretion is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive osteopetrosis 3 DOID:0110941 OMIM:259730
J:19268




Genotype
MGI:3783408
hm2
Allelic
Composition
Car2n/Car2n
Genetic
Background
involves: DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car2n mutation (1 available); any Car2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• rete testis dilated compared to wild-type, with equal or greater volume compared to Esr1-null mice
• ductules dilated compared to wild-type, with equal or greater volume compared to Esr1-null mice
• fertility is reduced with aging

endocrine/exocrine glands
• rete testis dilated compared to wild-type, with equal or greater volume compared to Esr1-null mice




Genotype
MGI:5543611
cx3
Allelic
Composition
Car2n/Car2n
Car7tm1.1Kkai/Car7tm1.1Kkai
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car2n mutation (1 available); any Car2 mutation (13 available)
Car7tm1.1Kkai mutation (0 available); any Car7 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• dendritic GABA-evoked depolarization is smaller in neurons from >P35 compared with wild-type neurons




Genotype
MGI:3784571
cx4
Allelic
Composition
Car2n/Car2n
Car9tm1Spas/Car9tm1Spas
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car2n mutation (1 available); any Car2 mutation (13 available)
Car9tm1Spas mutation (1 available); any Car9 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only one of 10 expected mice is born

digestive/alimentary system
• enlarged crypts of the small intestine
• mild pit-cell hyperplasia of the stomach

endocrine/exocrine glands
• enlarged crypts of the small intestine




Genotype
MGI:3784572
cx5
Allelic
Composition
Car2n/Car2n
Car9tm1Spas/Car9+
Genetic
Background
involves: C57BL/6J * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Car2n mutation (1 available); any Car2 mutation (13 available)
Car9tm1Spas mutation (1 available); any Car9 mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• 50% of mutants have gastric cysts

digestive/alimentary system
• some mutants exhibit intraepithelial lymphocytes in the duodenum
• 13% of mutants have mild glandular atrophy
• 50% of mutants have mild pit-cell hyperplasia
• 50% of mutants have gastric cysts
• bicarbonate secretory response of the duodenum to prostaglandin E2 (PGE2) is completely absent in mutants

endocrine/exocrine glands
• 13% of mutants have mild glandular atrophy





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/18/2022
MGI 6.17
The Jackson Laboratory