Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrtm1Wag mutation
(0 available);
any
Egfr mutation
(85 available)
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mortality/aging
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• Background Sensitivity: no mice are found at E12.5 on a 129 only background while mice survive longer on a mixed 129 C57BL/6 background
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growth/size/body
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• at E10.5, embryos are slightly reduced in size compared to controls
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• at E10.5, embryos are slightly reduced in weight compared to controls
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embryo
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• at E10.5, embryos are slightly reduced in size compared to controls
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• at E10.5, embryos are slightly reduced in weight compared to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrtm1Wag mutation
(0 available);
any
Egfr mutation
(85 available)
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mortality/aging
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• fewer mice than expected mice develop to term
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• Background Sensitivity: no mice survive until P20 unlike on a mixed 129 C57BL/6 MF1 background
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• fewer than expected mice are present at E11.5 and fewer mice than expected mice develop to term
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embryo
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• at E13.5, embryos are slightly reduced in size compared to controls
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• at E13.5, embryos are slightly reduced in weight compared to controls
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• at E13.5, placentas are structurally abnormal
• however, the labyrinthine trophoblast cells and the network of embryonic vessels and maternal sinuses appear normal
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• at E13.5, the maternal deciduas separates from fetal components more easily than in wild-type mice
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• the spongiotrphoblast layer is reduced in size compared to in wild-type mice
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respiratory system
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• mice display undifferentiated epithelium in the respiratory bronchioles
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• mice display undifferentiated epithelium in the alveoli
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• the number of cells in the alveolar septum is increased compared to in wild-type mice
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vision/eye
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• at birth, the cornea is thin and fibrotic
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• at E16.5, eyes are open and by birth eyelids have failed to grow and fused
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growth/size/body
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• at E13.5, embryos are slightly reduced in size compared to controls
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• at E13.5, embryos are slightly reduced in weight compared to controls
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reproductive system
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• at E13.5, the maternal deciduas separates from fetal components more easily than in wild-type mice
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integument
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• at birth some hair follicles appear less differentiated
• however, the number of hair follicles and organization of the dermal layer are similar to in wild-type mice
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• at birth, whiskers are absent or only rudimentary stubs are present
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• at E18.5, epidermal layers are not distinct
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• at E18.5, the stratum corneum lacks keratinization
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrtm1Wag mutation
(0 available);
any
Egfr mutation
(85 available)
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mortality/aging
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• fewer than expected mice survive until P20
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homeostasis/metabolism
growth/size/body
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• mice are 20% to 50% the size and weight of wild-type mice
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• mice are severely dehydrated and suffer from wasting syndrome 2 days before death
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrtm1Wag mutation
(0 available);
any
Egfr mutation
(85 available)
Egfrtm2(EGFR)Wag mutation
(0 available);
any
Egfr mutation
(85 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrtm1Wag mutation
(0 available);
any
Egfr mutation
(85 available)
Egfrtm2(EGFR)Wag mutation
(0 available);
any
Egfr mutation
(85 available)
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Analysis Tools