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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Flt1tm1Msh
targeted mutation 1, Masabumi Shibuya
MGI:1934260
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Flt1tm1Msh/Flt1tm1Msh involves: 129S4/SvJae * C57BL/6J MGI:2177813
hm2
Flt1tm1Msh/Flt1tm1Msh involves: 129S4/SvJaeSor * C57BL/6 * FVB MGI:5013922


Genotype
MGI:2177813
hm1
Allelic
Composition
Flt1tm1Msh/Flt1tm1Msh
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1tm1Msh mutation (0 available); any Flt1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• no abnormal cardiovascular phenotype is seen
• anti-Flt1 antibody treatment of mutant corneas induces vascularization; subconjunctival injection of anti-Flt1 antibodies also elicits corneal vascularization, but not in wild-type corneas
• corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice

reproductive system
N
• no abnormal reproductive phenotype is seen

vision/eye
• anti-Flt1 antibody treatment of mutant corneas induces vascularization; subconjunctival injection of anti-Flt1 antibodies also elicits corneal vascularization, but not in wild-type corneas
• corneal injection of a plasmid encoding short hairpin RNA targeting the C terminus of the secreted form of Flt1 (pshRNA-sflt1) induces corneal vascularization within 3 days of injection in wild-type and mutant mice

immune system
• VEGF-induced macrophage migration is almost completely abrogated

cellular
• VEGF-induced macrophage migration is almost completely abrogated

hematopoietic system
• VEGF-induced macrophage migration is almost completely abrogated




Genotype
MGI:5013922
hm2
Allelic
Composition
Flt1tm1Msh/Flt1tm1Msh
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1tm1Msh mutation (0 available); any Flt1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• challenge with high doses of paclitaxel by the subplantar route results in a more severe sensory deficit compared to wild-type

nervous system
• mice develop a distal neuropathy





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/03/2020
MGI 6.15
The Jackson Laboratory