Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf5tm1Par mutation
(0 available);
any
Ntf5 mutation
(12 available)
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nervous system
N |
• no defects in barrel cortex development
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf5tm1Par mutation
(0 available);
any
Ntf5 mutation
(12 available)
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behavior/neurological
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• ability to balance on a rotarod is reduced
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nervous system
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• reduction in number of differentiated dorsal root ganglion neurons at E13, indicating delayed neuronal differentiation
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• increase in proprioceptive muscle afferents as indicated by a 19% and 18% increase in the number of myelinated axons innervating the tibial nerve and the common peroneal nerve, respectively
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• altered sensory afferents as indicated by a 16% reduction in the number of myelinated axons innervating the saphenous nerve
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• 12% increase in neuron numbers in dorsal root ganglia at P0, but no differences at E13
• dorsal root ganglion neuronal cultures exhibit reduced numbers of Bdnf and Ntf5-responsive neurons and increased numbers of Ntf3-dependent neurons
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cellular
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• reduction in number of differentiated dorsal root ganglion neurons at E13, indicating delayed neuronal differentiation
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Par mutation
(0 available);
any
Bdnf mutation
(39 available)
Ntf5tm1Par mutation
(0 available);
any
Ntf5 mutation
(12 available)
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nervous system
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• reduction in number of differentiated dorsal root ganglion neurons at E13, indicating delayed neuronal differentiation, however numbers of sensory neurons are normal
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• dorsal root ganglion neuronal cultures exhibit reduced numbers of Bdnf and Ntf5-responsive neurons and increased numbers of Ntf3-dependent neurons
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cellular
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• reduction in number of differentiated dorsal root ganglion neurons at E13, indicating delayed neuronal differentiation, however numbers of sensory neurons are normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf3tm1Par mutation
(0 available);
any
Ntf3 mutation
(24 available)
Ntf5tm1Par mutation
(0 available);
any
Ntf5 mutation
(12 available)
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nervous system
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• 74% reduction of trigeminal ganglion neurons at P0
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• 46% and 84% reduction of dorsal root ganglion neurons at E13 and P0, respectively
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ntf5tm1Par mutation
(0 available);
any
Ntf5 mutation
(12 available)
Ntrk1tm1Par mutation
(0 available);
any
Ntrk1 mutation
(60 available)
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nervous system
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• 82% reduction of dorsal root ganglion neurons at P0
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