Analysis Tools
reproductive system
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• most of the growing mutant oocytes appear misshapen and unhealthy relative to wild-type oocytes
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• mutant oocytes grow to full size but lack the zona pellucida matrix
(J:33254)
(J:47519)
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• abnormal cumulus-oocyte complex
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• very few, if any, Graafian (antral) follicles are observed
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• delayed follicular development, esp. in juvenile (P20) female homozygotes
• at P35, most growing mutant oocytes are loosely associated with surrounding follicle cells
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• ovaries were 33-50% smaller than those of wild-type females at 14-20 days of age
(J:33254)
• mutant ovaries are consistently smaller than wild-type, with a ~4-fold size reduction noted at P20
(J:47519)
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• at P20, P35, and P70, the ratio of average ovarian weight (wild-type:mutant) is ~4, 1.7, and 1.3, respectively
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• few eggs are recovered after induced ovulation relative to wild-type
(J:33254)
• the number of oocytes obtained from ovaries of superovulated female homozygotes is only ~15% of that in wild-type females
(J:47519)
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(J:33254)
• matings of female homozygotes with homozygous or heterozygous mutant males result in no pregnancies
(J:47519)
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endocrine/exocrine glands
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• abnormal cumulus-oocyte complex
|
|
|
• very few, if any, Graafian (antral) follicles are observed
|
|
|
• delayed follicular development, esp. in juvenile (P20) female homozygotes
• at P35, most growing mutant oocytes are loosely associated with surrounding follicle cells
|
|
|
• ovaries were 33-50% smaller than those of wild-type females at 14-20 days of age
(J:33254)
• mutant ovaries are consistently smaller than wild-type, with a ~4-fold size reduction noted at P20
(J:47519)
|
|
|
• at P20, P35, and P70, the ratio of average ovarian weight (wild-type:mutant) is ~4, 1.7, and 1.3, respectively
|
cellular
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• most of the growing mutant oocytes appear misshapen and unhealthy relative to wild-type oocytes
|
|
|
• mutant oocytes grow to full size but lack the zona pellucida matrix
(J:33254)
(J:47519)
|
