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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Spp1tm1Blh
targeted mutation 1, Brigid L Hogan
MGI:1932083
Summary 18 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Spp1tm1Blh/Spp1tm1Blh 129S6/SvEvTac-Spp1tm1Blh MGI:4361701
hm2
Spp1tm1Blh/Spp1tm1Blh 129S/SvEv-Spp1tm1Blh MGI:4361711
hm3
Spp1tm1Blh/Spp1tm1Blh B6.129S6(Cg)-Spp1tm1Blh/J MGI:3580499
hm4
Spp1tm1Blh/Spp1tm1Blh B6.129S6-Spp1tm1Blh MGI:3758076
hm5
Spp1tm1Blh/Spp1tm1Blh BKSW.129S6-Spp1tm1Blh MGI:4361669
hm6
Spp1tm1Blh/Spp1tm1Blh involves: 129S6/SvEvTac MGI:4361680
hm7
Spp1tm1Blh/Spp1tm1Blh involves: 129S6/SvEvTac * Black Swiss MGI:3588986
hm8
Spp1tm1Blh/Spp1tm1Blh involves: 129S6/SvEvTac * C57BL/6 MGI:4361629
ht9
Spp1tm1Blh/Spp1+ BKSW.129S6-Spp1tm1Blh MGI:4361670
ht10
Spp1tm1Blh/Spp1+ involves: 129S6/SvEvTac * Black Swiss MGI:4361698
cx11
Spp1tm1Blh/Spp1tm1Blh
Umodtm1Xrw/Umodtm1Xrw
129S/SvEv-Spp1tm1Blh Umodtm1Xrw MGI:4361714
cx12
Apoetm1Unc/Apoetm1Unc
Spp1tm1Blh/Spp1+
involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J MGI:4361697
cx13
Apoetm1Unc/Apoetm1Unc
Spp1tm1Blh/Spp1tm1Blh
involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J MGI:4361696
cx14
Dmdmdx/Dmdmdx
Spp1tm1Blh/Spp1tm1Blh
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn MGI:4361735
cx15
Dmdmdx/Y
Spp1tm1Blh/Spp1tm1Blh
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn MGI:4361734
cx16
Mgptm1Kry/Mgptm1Kry
Spp1tm1Blh/Spp1tm1Blh
involves: Black Swiss * C57BL/6J MGI:3588990
cx17
Mgptm1Kry/Mgptm1Kry
Spp1tm1Blh/Spp1+
involves: Black Swiss * C57BL/6J MGI:3589019
cx18
Mgptm1Kry/Mgp+
Spp1tm1Blh/Spp1tm1Blh
involves: Black Swiss * C57BL/6J MGI:3589020


Genotype
MGI:4361701
hm1
Allelic
Composition
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background
129S6/SvEvTac-Spp1tm1Blh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• DMBA and TPA-treated mice exhibit delayed tumor development and reduced skin tumor multiplicity compared with similarly treated wild-type mice
• DMBA and TPA-treated male mice exhibit delayed development of tumor/papilloma appearance compared with similarly treated wild-type mice
• DMBA and TPA-induced tumors exhibit increased apoptosis compared to in similarly treated wild-type mice
• however, DMBA and TPA-induced cell proliferation is normal

homeostasis/metabolism
• DMBA and TPA-treated mice exhibit delayed tumor development and reduced skin tumor multiplicity compared with similarly treated wild-type mice
• DMBA and TPA-treated male mice exhibit delayed development of tumor/papilloma appearance compared with similarly treated wild-type mice
• DMBA and TPA-induced tumors exhibit increased apoptosis compared to in similarly treated wild-type mice
• however, DMBA and TPA-induced cell proliferation is normal




Genotype
MGI:4361711
hm2
Allelic
Composition
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background
129S/SvEv-Spp1tm1Blh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• urine chloride content is lower than in wild-type mice
• however, mice exhibit normal urine creatinine, calcium, magnesium, and citrate levels
• under hyperoxaluria conditions, 65% of mice exhibit small amounts of calcium crystalluria and renal calcium crystal formation unlike similarly treated wild-type mice
• 10% of mice exhibit calcifications in the renal papilla unlike wild-type mice
• renal epithelial cells exhibit a 3-fold increase in crystal adhesion to epithelial cells compared with wild-type cells
• 65% of mice exposed to hyperoxaluria develop renal calcinosis unlike similarly treated wild-type mice

homeostasis/metabolism
• urine chloride content is lower than in wild-type mice
• however, mice exhibit normal urine creatinine, calcium, magnesium, and citrate levels
• under hyperoxaluria conditions, 65% of mice exhibit small amounts of calcium crystalluria and renal calcium crystal formation unlike similarly treated wild-type mice




Genotype
MGI:3580499
hm3
Allelic
Composition
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background
B6.129S6(Cg)-Spp1tm1Blh/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• despite strong Spp1+ mRNA expression in wild-type testis cords and protein localization in the cytoplasm of Sertoli cells, testes from E13.5 homozygotes show no differences in the number or distribution of Sertoli, Leydig, or germ cells relative to wild-type testes

hematopoietic system
• hematocrit levels in male mice are 10% to 12% lower than in wild-type mice
• however, hematocrit levels in female mice are normal
• hemoglobin levels in male mice are 10% to 12% lower than in wild-type mice
• however, hemoglobin levels in female mice are normal
• proliferation of cultured erythroblasts isolated from the bone marrow is less than proliferation of wild-type cells
• however, differentiation and apoptosis of erythroblasts are normal and addition of exogenous Spp1 restores erythroblast proliferation rates




Genotype
MGI:3758076
hm4
Allelic
Composition
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background
B6.129S6-Spp1tm1Blh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• neuronal cell death in MPTP-treated homozygotes is comparable to sham-treated wildtype and significantly less than MPTP-treated wildtype, suggesting a protective effect
• MPTP-treated mice exhibit decreased microglial cells with longer processes compared with similarly treated wild-type mice
• MPTP-treated homozygotes exhibit an increase in the number of microglial cells, however, MPTP-treated wildtype mice exhibited a greater increase
• numbers of GFAP-positive astrocytes increased in the MPTP-treated wildtype mice, but not in MPTP-treated homozygotes or sham-treated wildtype mice
• astrocytic processes are longer in MPTP-treated homozygotes than in both MPTP-treated wildtype and sham-treated wildtype mice
• tyrosine hydroxylase (TH) positive nerve fibers in the striatum are decreased to a lesser extent in MPTP-treated homozygotes than in MPTP-treated wildtype mice
• MPTP-treated mice exhibit increased neuron and TH+ fiber survival compared to in similarly treated wild-type mice

immune system
• MPTP-treated mice exhibit decreased microglial cells with longer processes compared with similarly treated wild-type mice
• mice exhibit decreased incidence of experimental autoimmune uveoretinitis with fewer infiltrating inflammatory cells in the vitreous, decreased granulomas, and reduced lymphocyte proliferation compared with similarly treated wild-type mice
• mice exhibit decreased granulomas in a model of experimental autoimmune uveoretinitis compared with similarly treated wild-type mice

hematopoietic system
• MPTP-treated mice exhibit decreased microglial cells with longer processes compared with similarly treated wild-type mice

homeostasis/metabolism
• MPTP-treated mice exhibit increased neuron and TH+ fiber survival and decreased microglial cells with longer processes compared with similarly treated wild-type mice
• neuronal cell death in MPTP-treated homozygotes is comparable to sham-treated wildtype and significantly less than MPTP-treated wildtype, suggesting a protective effect

cellular
• neuronal cell death in MPTP-treated homozygotes is comparable to sham-treated wildtype and significantly less than MPTP-treated wildtype, suggesting a protective effect




Genotype
MGI:4361669
hm5
Allelic
Composition
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background
BKSW.129S6-Spp1tm1Blh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the foreign body response provoked by glutaraldehyde-fixed aortic valve leaflets is diminished in quality with a 50% to 25% reduction in macrophage recruitment, a four- to five-fold increase calcification of the leaflet, and acidification of the leaflet compared to in similarly treated wild-type mice
• mice exhibit a 50% to 25% reduction in macrophage recruitment to a transplanted glutaraldehyde-fixed aortic valve leaflet compared to in similarly treated wild-type mice

cellular
• mice exhibit a 50% to 25% reduction in macrophage recruitment to a transplanted glutaraldehyde-fixed aortic valve leaflet compared to in similarly treated wild-type mice

cardiovascular system
• the foreign body response provoked by glutaraldehyde-fixed aortic valve leaflets is diminished in quality with a four- to five-fold increase calcification of the leaflet compared to in similarly treated wild-type mice

hematopoietic system
• mice exhibit a 50% to 25% reduction in macrophage recruitment to a transplanted glutaraldehyde-fixed aortic valve leaflet compared to in similarly treated wild-type mice




Genotype
MGI:4361680
hm6
Allelic
Composition
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• at 16 weeks, the ratio of mineral to matrix is increased in the cortical center and area of cortical bone adjacent to the endosteum compared to in wild-type mice
• crystallinity in the bones of younger mice is increased compared to in wild-type mice




Genotype
MGI:3588986
hm7
Allelic
Composition
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• under normal conditions, homozygotes are viable and fertile, with no apparent defects in growth, external morphology or behavior
• importantly, unwounded skin from homozygotes displays normal tissue architecture and cell organization in the subepithelial, middermal, and deep dermal regions; differences in dermal organization become significant only in the context of the healing process

immune system
• peritoneal exudates exhibit decreased numbers of inflammatory cells compared with wild-type exudate
• however, serum white blood cell counts are normal
• mice fed a high-fat diet exhibit reduced accumulation of macrophages in adipose tissue compared with similarly treated wild-type mice
• leukocytes from peritoneal exudates of Ang-II-stimulated mice exhibit decreased viability compared with cells from similarly treated wild-type mice
• leukocytes exhibit decreased basal and absent MCP-1-dependent migration compared with similarly treated wild-type and heterozygous cells
• microphages are hypomotile with reduced basal motility and absent MCP-1-stimulated motility unlike wild-type cells
• exogenous Spp1 only partially rescues macrophage motility
• migration of macrophages from obese mice towards stromal vascular cells is decreased compared with wild-type cells
• increased numbers of macrophage in the liver after infection
• peritoneal exudate cells elevated at 72 hours after infection relative to controls
• compared to in wild-type mice when fed a high-fat diet
• when fed a high-fat diet, plasma levels of MCP-1 (Ccl2) and PAI-1 (Serpine1) are decreased compared to in similarly treated wild-type mice
• overall greater burden of granulomas after infection than in controls, 3.1% of liver tissue compared to 1.1%
• following exposure to Schistosoma mansoni eggs, pulmonary granuloma lesions formation is delayed, granuloma size is reduced at early time points but increased at later time points, and clearance is delayed compared to in similarly treated wild-type mice
• at day 75 of S. mansoni infection, granulomas are composed of mononuclear cells unlike wild-type granulomas with epithelioid morphology
• S. mansoni egg-exposed mice exhibit reduced giant cells in granulomas until day 75 when giant cell formation is increased compared to in similarly treated wild-type mice
• S. mansoni egg-exposed mice exhibit granulomas with few or no macrophages unlike in similarly treated wild-type mice
• however, T cell accumulation in S. mansoni egg granulomas is normal
• Mycobacterium bovis persists for at least 4 weeks after infections in livers and spleens at levels 10-40X those found in controls
• bacterial loads are reduced by 12 weeks after infection

homeostasis/metabolism
N
• mice exhibit normal serum and urine biochemistry
• following myocardial infarction, mice exhibit increased left ventricular mid-papillary circumference, lung weight, and left ventricle volume to heart weight ratio with a greater rightward shift in left ventricle pressure-volume relationship and decreases in chamber stiffness constant, myocyte length, and collagen content compared with similarly treated wild-type mice
• however, mice exhibit normal infarct size, heart weight, number of apoptotic myocytes, and survival
• compared to in wild-type mice when fed a high-fat diet
• compared to in wild-type mice when fed a high-fat diet
• compared to in wild-type mice when fed a high-fat diet
• compared to in wild-type mice when fed a high-fat diet
• when fed a high-fat diet, mice exhibit a modest increase in respiratory quotient during the 12-hour light cycle compared with similarly treated wild-type mice
• however, mice fed a high-fat diet exhibit a normal respiratory quotient when analyzed over a 24 hour period
• compared to in wild-type mice when fed a high-fat diet
• compared to in wild-type mice when fed a high-fat diet
• when fed a high-fat diet, plasma levels of MCP-1 (Ccl2) and PAI-1 (Serpine1) are decreased compared to in similarly treated wild-type mice
• 4 weeks following hyperoxaluria induction with 1% ethylene glycol, mice exhibit CaOx monohydrate crystalluria and retention in renal tubes unlike treated wild-type mice
• bleomycin-treated mice exhibit an increase in the number and size of cystic epithelial lined air spaces within fibrotic areas of the lung compared to in similarly treated wild-type mice
• at 2 weeks after dermal incisional wounding, homozygotes exhibit reduced debridement throughout the wound site, esp. in the subepithelial dermis
• in resolving wounds, the reforming matrix appears to be less organized in both the subepithelial and middermal regions
• in the subepithelial and middermal zones, the organization of collagen fibrils and fibers is less distinct
• in the deep reticular dermis, the collagen fibril diameter is significantly smaller; fibrils remain small, with a homogeneous distribution at all wound levels
• notably, homozygotes show no significant differences in tensile strength of healing incisional wounds relative to wild-type mice
• following carotid artery ligation, mice exhibit a 10-fold decrease leukocyte infiltration, decreased neointimal formation, and greater constrictive remodeling resulting in normal lumen area but decreased medial area compared with similarly treated wild-type mice
• however, cell proliferation and apoptosis during blood vessel healing is normal at 14 days

cardiovascular system
• however, elastic fibers surrounding blood vessels are normal
• the collagenous matrix around blood vessels is more loosely organized compared to in wild-type mice
• mice exhibit reduced Angiotensin II-induced atherosclerotic lesions compared with Apoetm1Unc homozygotes
• bone marrow used to repopulate irradiated Apoetm1Unc homozygotes confers decreased susceptibility to Ang-II-induced atherosclerosis
• blood flow at similar heart rates is decreased compared to in wild-type mice
• following myocardial infarction, mice exhibit increased left ventricular mid-papillary circumference, lung weight, and left ventricle volume to heart weight ratio with a greater rightward shift in left ventricle pressure-volume relationship and decreases in chamber stiffness constant, myocyte length, and collagen content compared with similarly treated wild-type mice
• however, mice exhibit normal infarct size, heart weight, number of apoptotic myocytes, and survival
• vascular tone and compliance are increased compared to in wild-type mice
• blood vessels dilate rapidly at lower pressures than similarly treated wild-type vessels
• following carotid artery ligation, mice exhibit a 10-fold decrease leukocyte infiltration, decreased neointimal formation, and greater constrictive remodeling resulting in normal lumen area but decreased medial area compared with similarly treated wild-type mice
• however, cell proliferation and apoptosis during blood vessel healing is normal at 14 days

renal/urinary system
N
• mice exhibit normal urine biochemistry
• 4 weeks following hyperoxaluria induction with 1% ethylene glycol, mice exhibit CaOx monohydrate crystalluria and retention in renal tubes unlike treated wild-type mice

respiratory system
• bleomycin-treated mice exhibit an increase in the number and size of cystic epithelial lined air spaces within fibrotic areas of the lung compared to in similarly treated wild-type mice
• following myocardial infarction

growth/size/body
• compared to in wild-type mice when fed a high-fat diet
• bleomycin-treated mice exhibit an increase in the number and size of cystic epithelial lined air spaces within fibrotic areas of the lung compared to in similarly treated wild-type mice
• following myocardial infarction

hematopoietic system
• peritoneal exudates exhibit decreased numbers of inflammatory cells compared with wild-type exudate
• however, serum white blood cell counts are normal
• mice fed a high-fat diet exhibit reduced accumulation of macrophages in adipose tissue compared with similarly treated wild-type mice
• leukocytes from peritoneal exudates of Ang-II-stimulated mice exhibit decreased viability compared with cells from similarly treated wild-type mice
• leukocytes exhibit decreased basal and absent MCP-1-dependent migration compared with similarly treated wild-type and heterozygous cells
• microphages are hypomotile with reduced basal motility and absent MCP-1-stimulated motility unlike wild-type cells
• exogenous Spp1 only partially rescues macrophage motility
• migration of macrophages from obese mice towards stromal vascular cells is decreased compared with wild-type cells
• increased numbers of macrophage in the liver after infection
• peritoneal exudate cells elevated at 72 hours after infection relative to controls

muscle
• blood vessels dilate rapidly at lower pressures than similarly treated wild-type vessels

cellular
• leukocytes exhibit decreased basal and absent MCP-1-dependent migration compared with similarly treated wild-type and heterozygous cells
• increased numbers of macrophage in the liver after infection
• peritoneal exudate cells elevated at 72 hours after infection relative to controls




Genotype
MGI:4361629
hm8
Allelic
Composition
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice sensitized with TNCB and challenged hapten exhibit reduced numbers of CD11c+FITC+ cells in the skin draining lymph nodes compared with similarly treated wild-type mice
• 75% less injected wild-type dendritic cells enter the axillary and inguinal lymph nodes

homeostasis/metabolism
• mice sensitized with TNCB and challenged hapten exhibit reduced ear swelling and reduced numbers of CD11c+FITC+ cells in the skin draining lymph nodes compared with similarly treated wild-type mice

hematopoietic system
• mice sensitized with TNCB and challenged hapten exhibit reduced numbers of CD11c+FITC+ cells in the skin draining lymph nodes compared with similarly treated wild-type mice




Genotype
MGI:4361670
ht9
Allelic
Composition
Spp1tm1Blh/Spp1+
Genetic
Background
BKSW.129S6-Spp1tm1Blh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the foreign body response provoked by glutaraldehyde-fixed aortic valve leaflets is diminished in quality with a four- to five-fold increase calcification of the leaflet compared to in similarly treated wild-type mice

cardiovascular system
• the foreign body response provoked by glutaraldehyde-fixed aortic valve leaflets is diminished in quality with a four- to five-fold increase calcification of the leaflet compared to in similarly treated wild-type mice




Genotype
MGI:4361698
ht10
Allelic
Composition
Spp1tm1Blh/Spp1+
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• leukocytes exhibit decreased basal and MCP-1-dependent migration compared with similarly treated wild-type cells

cellular
• leukocytes exhibit decreased basal and MCP-1-dependent migration compared with similarly treated wild-type cells

hematopoietic system
• leukocytes exhibit decreased basal and MCP-1-dependent migration compared with similarly treated wild-type cells




Genotype
MGI:4361714
cx11
Allelic
Composition
Spp1tm1Blh/Spp1tm1Blh
Umodtm1Xrw/Umodtm1Xrw
Genetic
Background
129S/SvEv-Spp1tm1Blh Umodtm1Xrw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
Umodtm1Xrw mutation (0 available); any Umod mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• urine phosphorus and calcium phosphate content are higher than in wild-type mice
• under hyperoxaluria conditions, 95% of mice exhibit large amounts of calcium crystalluria and renal calcium crystal formation unlike similarly treated wild-type mice
• after 1 month of hyperoxaluria, 18% of mice develop large crystalline deposits at the tip of the renal papillae that can block the proximal portions of the collecting ducts unlike similarly treated wild-type mice
• following hyperoxaluria, mice develop stones unlike similarly treated wild-type mice
• in some mice after 1 month of hyperoxaluria
• 39% of mice exhibit calcifications in the renal papilla unlike wild-type mice
• renal epithelial cells exhibit a 3.5-fold increase in crystal adhesion to epithelial cells compared with wild-type cells
• 95% of mice exposed to hyperoxaluria develop renal calcinosis unlike similarly treated wild-type mice
• following hyperoxaluria, mice exhibit greater renal damage and fibrosis than similarly treated wild-type mice

homeostasis/metabolism
• urine phosphorus and calcium phosphate content are higher than in wild-type mice
• under hyperoxaluria conditions, 95% of mice exhibit large amounts of calcium crystalluria and renal calcium crystal formation unlike similarly treated wild-type mice
• after 1 month of hyperoxaluria, 18% of mice develop large crystalline deposits at the tip of the renal papillae that can block the proximal portions of the collecting ducts unlike similarly treated wild-type mice
• following hyperoxaluria, mice develop stones unlike similarly treated wild-type mice




Genotype
MGI:4361697
cx12
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Spp1tm1Blh/Spp1+
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (138 available)
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• Angiotensin II-induced atherosclerotic lesions exhibit reduced lesion area compared to in similarly treated Apoetm1Unc homozygotes




Genotype
MGI:4361696
cx13
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (138 available)
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• Angiotensin II-induced atherosclerotic lesions exhibit reduced medial inflammation, lesion area, cellularity, macrophage viability, and foam cells compared to in similarly treated Apoetm1Unc homozygotes
• however, untreated aged male mice exhibit normal atherosclerotic lesion development
• Angiotensin II-treated mice exhibit reduced abdominal aortic aneurysm incidence and diameter compared with similarly treated Apoetm1Unc homozygotes

immune system
• macrophage viability in Angiotensin II-treated mice is lower than in similarly treated Apoetm1Unc homozygotes

hematopoietic system
• macrophage viability in Angiotensin II-treated mice is lower than in similarly treated Apoetm1Unc homozygotes




Genotype
MGI:4361735
cx14
Allelic
Composition
Dmdmdx/Dmdmdx
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx mutation (28 available); any Dmd mutation (153 available)
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Reduced diaphragm and cardiac fibrosis in Dmdmdx/Y Spp1tm1Blh/Spp1tm1Blh and Dmdmdx/Dmdmdx Spp1tm1Blh/Spp1tm1Blh mice compared to Dmdmdx/Dmdmdx mice

immune system
• muscles contain fewer granulocytes than in Dmdmdx homozygotes
• muscles contain fewer neutrophils than in Dmdmdx homozygotes
• muscles contain fewer CD3+/Vbeta8.1/8.2+, and NKT-like cells than in Dmdmdx homozygotes
• muscles contain more CD3+ T cells than in Dmdmdx homozygotes
• muscles contain more CD3+CD4+ regulatory T cells than in Dmdmdx homozygotes

muscle
• mice exhibit improved muscle regeneration and reduced muscle inflammation and fibrosis in the diaphragm and heart compared with Dmdmdx homozygotes

behavior/neurological
• at 4 and 8 weeks, mice exhibit increased strength on a wire and grip test compared with Dmdmdx homozygotes

hematopoietic system
• muscles contain fewer granulocytes than in Dmdmdx homozygotes
• muscles contain fewer neutrophils than in Dmdmdx homozygotes
• muscles contain fewer CD3+/Vbeta8.1/8.2+, and NKT-like cells than in Dmdmdx homozygotes
• muscles contain more CD3+ T cells than in Dmdmdx homozygotes
• muscles contain more CD3+CD4+ regulatory T cells than in Dmdmdx homozygotes




Genotype
MGI:4361734
cx15
Allelic
Composition
Dmdmdx/Y
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * C57BL/10ScSn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx mutation (28 available); any Dmd mutation (153 available)
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Reduced diaphragm and cardiac fibrosis in Dmdmdx/Y Spp1tm1Blh/Spp1tm1Blh and Dmdmdx/Dmdmdx Spp1tm1Blh/Spp1tm1Blh mice compared to Dmdmdx/Dmdmdx mice

immune system
• muscles contain fewer granulocytes than in Dmdmdx homozygotes
• muscles contain fewer neutrophils than in Dmdmdx homozygotes
• muscles contain fewer CD3+/Vbeta8.1/8.2+, and NKT-like cells than in Dmdmdx homozygotes
• muscles contain more CD3+ T cells than in Dmdmdx homozygotes
• muscles contain more CD3+CD4+ regulatory T cells than in Dmdmdx homozygotes

muscle
• mice exhibit improved muscle regeneration and reduced muscle inflammation and fibrosis in the diaphragm and heart compared with Dmdmdx homozygotes

behavior/neurological
• at 4 and 8 weeks, mice exhibit increased strength on a wire and grip test compared with Dmdmdx homozygotes

hematopoietic system
• muscles contain fewer granulocytes than in Dmdmdx homozygotes
• muscles contain fewer neutrophils than in Dmdmdx homozygotes
• muscles contain fewer CD3+/Vbeta8.1/8.2+, and NKT-like cells than in Dmdmdx homozygotes
• muscles contain more CD3+ T cells than in Dmdmdx homozygotes
• muscles contain more CD3+CD4+ regulatory T cells than in Dmdmdx homozygotes




Genotype
MGI:3588990
cx16
Allelic
Composition
Mgptm1Kry/Mgptm1Kry
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background
involves: Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mgptm1Kry mutation (1 available); any Mgp mutation (7 available)
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• on average, double homozygotes die significantly earlier (4.4 0.2 weeks) than single Mgptm1Kry homozygotes (6.6 1.0 weeks) as a result of increased vascular calcification
• accelerated vascular calcification correlates with accelerated vascular rupture, subsequent hemorrhage and increaed mortality

cardiovascular system
• relative to single Mgptm1Kry homozygotes, double homozygotes exhibit an accelerated and enhanced medial calcification of their aortae, with a ~2-fold and a >3-fold increase in calcification noted at 2 weeks and 4 weeks, respectively
• calcification initiates in the arterial media in association with elastic lamina, and progresses to fully mineralized media, mild to moderate intimal and medial thickening, fragmentation of elastic laminae, and arterial wall rupture
• arterial calcification ultimately results in aneurysm formation in calcified vessels
• similar to Mgptm1Kry single homozygotes, double homozygotes exhibit vascular rupture and subsequent hemorrhage as a result of severe vascular calcification




Genotype
MGI:3589019
cx17
Allelic
Composition
Mgptm1Kry/Mgptm1Kry
Spp1tm1Blh/Spp1+
Genetic
Background
involves: Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mgptm1Kry mutation (1 available); any Mgp mutation (7 available)
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice homozygous for Mgptm1Kry and heterozygous for Spp1tm1Blh start to die during weeks 3 and 4 after birth as a result of vascular rupture and subsequent internal hemorrhage

cardiovascular system




Genotype
MGI:3589020
cx18
Allelic
Composition
Mgptm1Kry/Mgp+
Spp1tm1Blh/Spp1tm1Blh
Genetic
Background
involves: Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mgptm1Kry mutation (1 available); any Mgp mutation (7 available)
Spp1tm1Blh mutation (2 available); any Spp1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice heterozygous for Mgptm1Kry and homozygous for Spp1tm1Blh start to die during weeks 3 and 4 after birth as a result of vascular rupture and subsequent internal hemorrhage

cardiovascular system
• ~30% of mice heterozygous for Mgptm1Kry and homozygous for Spp1tm1Blh exhibit overt vascular calcification at 4-8 weeks
• in contrast, mice heterozygous for Mgptm1Kry and homozygous for wild-type Spp1 do NOT exhibit vascular calcification at any time point examined





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory