Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13tm2Anjm mutation
(6 available);
any
Il13 mutation
(29 available)
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immune system
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• decrease in the number of CD11b+ cells in the brain and spinal cord in female mice
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• production of IL12 and IFNG by mononuclear cells from female mice stimulated with MOG-35?55 is significantly reduced compared to cells from male mice
• production of EAE associated chemokines by mononuclear cells from female mice is reduced compared to cells from male mice
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• antigen presenting cells taken from female mice at the peak of EAE stimulated with MOG-35?55 present antigen with reduced efficiency compared to cells from male mice
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• females develop EAE with reduced severity or are resistant to EAE compared to wild-type females
• however, EAE severity in males is similar to wild-type males
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hematopoietic system
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• decrease in the number of CD11b+ cells in the brain and spinal cord in female mice
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• production of IL12 and IFNG by mononuclear cells from female mice stimulated with MOG-35?55 is significantly reduced compared to cells from male mice
• production of EAE associated chemokines by mononuclear cells from female mice is reduced compared to cells from male mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13tm2Anjm mutation
(6 available);
any
Il13 mutation
(29 available)
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immune system
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• neutralizing IL14 reduces response in sensitized mice down to that in unsensitized mice, unlike in wild-type mice
• neutralizing IL15 also reduces response in sensitized mutant mice but not in wild-type mice
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• show a heightened response relative to wild-type mice in a model of airways hyperreactivity (sensitized
and aeroallergen challenged with OVA followed by challenge with Beta-metacholine)
• however, mucus hypersecretion in this model of airways hyperreactivity is reduced
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• decrease in luminal occlusion in tracheal allografts from C57BL/6 mice compared to transplants into wild-type mice
• allografts do not show a significant upregulation of TGFB1 compared to isografts
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• tracheal allografts from C57BL/6 mice display prolonged maintenance of epithelial integrity and absence of luminal fibroproliferation
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13tm2Anjm mutation
(6 available);
any
Il13 mutation
(29 available)
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hematopoietic system
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• much fewer Th2 cells are developed in vitro when nave CD4 T cells are cultured under Th2-polarizing conditions
• Th2 cells are produced under chronic N. brasiliensis infection
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• much fewer Th2 cells are found in vitro
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• total IgE levels are decreased 5- to 20- fold
• however, IgE levels are comparable to wild-type when mice are immunized
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• there are increased amounts of antigen-specific IgG2b levels when mice are immunized compared to controls
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• there are increased amounts of antigen-specific IgM levels when mice are immunized compared to control
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homeostasis/metabolism
immune system
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• much fewer Th2 cells are developed in vitro when nave CD4 T cells are cultured under Th2-polarizing conditions
• Th2 cells are produced under chronic N. brasiliensis infection
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• much fewer Th2 cells are found in vitro
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• total IgE levels are decreased 5- to 20- fold
• however, IgE levels are comparable to wild-type when mice are immunized
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• there are increased amounts of antigen-specific IgG2b levels when mice are immunized compared to controls
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• there are increased amounts of antigen-specific IgM levels when mice are immunized compared to control
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• IL-13 are absent in these mice
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• IFN-gamma secretion is 2-fold compared to controls when CD4 T cells are restimulated compared to controls
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• IL-10 secretion is reduced 2-fold compared to controls when nave CD4 T cells are cultured under Th2-polarizing conditions
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• IL-4 secretion is dramatically decreased compared to controls when nave CD4 T cells are cultured under Th2-polarizing conditions
• schistosome eggs, an antigen that induces Th2 cell responses, induces a 2-fold decreased IL-4 response than controls
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• IL-5 secretion is dramatically decreased compared to controls when nave CD4 T cells are cultured under Th2-polarizing conditions
• schistosome eggs, an antigen that induces Th2 cell responses, induces a 2-fold decreased IL-5 response than controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13tm2Anjm mutation
(6 available);
any
Il13 mutation
(29 available)
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mortality/aging
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• decreased mortality following acute infection with Schistosoma mansoni compared to wild-type mic
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immune system
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• in mice sensitized by injection of alum-precipitated chicken egg ovalbumin the exposed to low levels of aerosolized antigen little evidence of recruitment of eosinophils into the tracheal epithelium is seen
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• to the liver following ischemia/reperfusion resulting from an apparent defect in transendothelial migration
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• phagocytosis of Chlamydia muridarum is enhanced in vitro and in vivo
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• in mice immunized with recombinant vvG levels of CCL11 and CCL22 are reduced in the lungs
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• mice immunized with recombinant vvG (vaccinia virus expressing the G protein of respiratory syncytial virus (RSV)) then challenged with RSV display lower percentages and total numbers of eosinophils in the bronchoalveolar lavage (BAL) compared to wild-type mice
• in mice immunized with recombinant vvG and then challenged with RSV eosinophilia in both perivascular and interstitial regions of the lung is significantly decreased
• however, levels of eosinophils in the blood and bone marrow are similar to controls
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• after respiratory infection with Chlamydia muridarum (Cmu) mice do not lose weight, show reduced bacterial loads in the lungs and reduced airway inflammation
• mice are also resistant to genital tract Cmu infection
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• negligible hepatic fibrosis following infection with Schistosoma mansoni unlike in wild-type mice
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• decreased mortality following acute infection with Schistosoma mansoni compared to wild-type mic
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homeostasis/metabolism
hematopoietic system
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• in mice sensitized by injection of alum-precipitated chicken egg ovalbumin the exposed to low levels of aerosolized antigen little evidence of recruitment of eosinophils into the tracheal epithelium is seen
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• to the liver following ischemia/reperfusion resulting from an apparent defect in transendothelial migration
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• phagocytosis of Chlamydia muridarum is enhanced in vitro and in vivo
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13tm2Anjm mutation
(6 available);
any
Il13 mutation
(29 available)
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mortality/aging
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• decreased mortality following chronic infection with Schistosoma mansoni compared to wild-type mice
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immune system
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N |
• development of skin lesion sin response to Leishmania mexicana infection is similar to that in wild-type mice
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• homozygotes display impaired pulmonary granuloma formation in response to schistosome egg immunization
• eosinophil infiltration is impaired in response to schistosome egg immunization
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• Leishmania mexicana antigen stimulated cells from L. mexicana infected mice produce increased amounts of IL12
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• decreased mortality following chronic infection with Schistosoma mansoni compared to wild-type mice
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• the expulsion of parasitic worms from the gut is delayed
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hematopoietic system
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• homozygotes display impaired pulmonary granuloma formation in response to schistosome egg immunization
• eosinophil infiltration is impaired in response to schistosome egg immunization
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• Leishmania mexicana antigen stimulated cells from L. mexicana infected mice produce increased amounts of IL12
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il13tm2Anjm mutation
(6 available);
any
Il13 mutation
(29 available)
Tg(SFTPC-Il18)AThos mutation
(0 available)
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growth/size/body
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• mice show a decrease in body weight from 16 to 24 weeks of age, however weight loss is less than seen in single transgenic Tg(SFTPC-Il18)AThos mice
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respiratory system
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• mean alveolar chord lengths of 14 week old mice is shorter than in single transgenic mice
• however, pulmonary inflammation and emphysematous changes are not seen in the lungs
enlarged alveolar macrophages and exudates are not present in the lungs
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muscle
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• decrease in quadriceps femoris muscle weight at 7 and 16 weeks of age, although muscle is heavier than in single transgenic Tg(SFTPC-Il18)AThos mice and by 25 weeks of age, weight is similar to wild-type mice
• mice show a decrease in gastrocnemius muscle weight at 7 weeks of age but not 16 and 25 weeks of age
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skeleton
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• bone mineral density is normal
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Analysis Tools