Phenotypes associated with this allele

• Allele Symbol: Jag1^Slalom
• Allele Name: slalom
• Allele ID: MGI:1931798
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jag1^Slalom/Jag1^Slalom	involves: BALB/c * C3H	MGI:3587505
ht2	Jag1^Slalom/Jag1^+	involves: BALB/c * C3H	MGI:3587506
ht3	Jag1^Mhdahtu/Jag1^Slalom	involves: BALB/c * C3H * C3HeB/FeJ	MGI:3717465

Genotype
MGI:3587505

hm1

• Allelic Composition: Jag1^Slalom/Jag1^Slalom
• Genetic Background: involves: BALB/c * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:67728 )

• survival to about E12.5

embryo

abnormal vitelline vasculature morphology ( J:67728 )

• reduced large vasculature in yolk sac

abnormal neural tube morphology ( J:67728 )

• neural tube defects in about 30% of embryos

nervous system

abnormal neural tube morphology ( J:67728 )

• neural tube defects in about 30% of embryos

cardiovascular system

abnormal vitelline vasculature morphology ( J:67728 )

• reduced large vasculature in yolk sac

Genotype
MGI:3587506

ht2

• Allelic Composition: Jag1^Slalom/Jag1⁺
• Genetic Background: involves: BALB/c * C3H

behavior/neurological

head shaking ( J:67728 )

• subtle headweaving/shaking behavior

positive geotaxis ( J:67728 )

• described as poor negative geotaxis

hearing/vestibular/ear

abnormal cochlear sensory epithelium morphology ( J:67728 )

• supernumary or atypical outer hair cells sometimes found in inner hair cell rows

decreased cochlear outer hair cell number ( J:67728 )

• reduced numbers of outer hair cells

• some regions lacking entire rows while isolated hair cells missing in other regions

• decreased outer hair cell counts in both basal and apical turns

increased cochlear inner hair cell number ( J:67728 )

• significantly increased inner hair cell counts in base of cochlea but not apical regions

abnormal semicircular canal morphology ( J:67728 )

• either posterior or anterior semicircular canal truncated

• sometimes both anterior and posterior semicircular canals absent

abnormal semicircular canal ampulla morphology ( J:67728 )

• absence of ampullae

nervous system

decreased cochlear outer hair cell number ( J:67728 )

• reduced numbers of outer hair cells

• some regions lacking entire rows while isolated hair cells missing in other regions

• decreased outer hair cell counts in both basal and apical turns

increased cochlear inner hair cell number ( J:67728 )

• significantly increased inner hair cell counts in base of cochlea but not apical regions

Genotype
MGI:3717465

ht3

• Allelic Composition: Jag1^Mhdahtu/Jag1^Slalom
• Genetic Background: involves: BALB/c * C3H * C3HeB/FeJ

mortality/aging

embryonic lethality during organogenesis ( J:72108 )

embryo

abnormal vitelline vasculature morphology ( J:72108 )

• absence of blood vessels in the yolk sac

embryo tissue necrosis ( J:72108 )

• embryos are either necrotic or hemorrhagic

cardiovascular system

abnormal vitelline vasculature morphology ( J:72108 )

• absence of blood vessels in the yolk sac

hemorrhage ( J:72108 )

• embryos are either necrotic or hemorrhagic

cellular

embryo tissue necrosis ( J:72108 )

• embryos are either necrotic or hemorrhagic