Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgamtm1Myd mutation
(1 available);
any
Itgam mutation
(47 available)
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immune system
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• neutrophils that accumulate at the site of a local Shwartman response are round instead of flattened as in wild-type mice
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• neutrophil degranulation after adhesion is decreased compared to in wild-type mice
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• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice fail to exhibit hemorrhage and have fewer thrombus-occluded vessels and reduced fibrin compared to the thrombohemorrhagic vasculitis observed in wild-type mice
• however, neutrophil accumulation at the site of the Shwartman response is normal and adoptive transfer of neutrophils into a wild-type mouse elicits a normal local Shwartman response
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homeostasis/metabolism
hematopoietic system
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• neutrophils that accumulate at the site of a local Shwartman response are round instead of flattened as in wild-type mice
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• neutrophil degranulation after adhesion is decreased compared to in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgamtm1Myd mutation
(1 available);
any
Itgam mutation
(47 available)
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immune system
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• absence of rolling following needle puncture of mesenteric veins
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cellular
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• absence of rolling following needle puncture of mesenteric veins
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hematopoietic system
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• absence of rolling following needle puncture of mesenteric veins
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgamtm1Myd mutation
(1 available);
any
Itgam mutation
(47 available)
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cellular
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• in cultured total leukocyte populations from harvested peritoneal exudates, extravasated null neutrophils show a 56% and 45% reduction in apoptosis after 6 and 8 hours in culture respectively, compared to wild-type neutrophils
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• neutrophils from null animals are significantly impaired with respect to their ability to adhere to the endothelium in response to leukotriene B4
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• null neurophils isolated from peritoneal lavage of thioglycollate-treated mice are unable to phagocytose complement-opsonized particles; neutrophil spreading on glass is attenuated in null neutrophils; these neutrophils also show a 60% reduction in the oxidative burst associated with phagocytosis
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hematopoietic system
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• neutrophils from null animals are significantly impaired with respect to their ability to adhere to the endothelium in response to leukotriene B4
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• null neurophils isolated from peritoneal lavage of thioglycollate-treated mice are unable to phagocytose complement-opsonized particles; neutrophil spreading on glass is attenuated in null neutrophils; these neutrophils also show a 60% reduction in the oxidative burst associated with phagocytosis
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• mutants show increased eosinophil accumulation at 10.5 hours, 48 hours and 5 days in the model of peritonitis
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• null animals have 2-fold more neutrophils in the peritoneal exudates after 2 hours in an experimental model of peritonitis than did wild-type animals
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immune system
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• neutrophils from null animals are significantly impaired with respect to their ability to adhere to the endothelium in response to leukotriene B4
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• null neurophils isolated from peritoneal lavage of thioglycollate-treated mice are unable to phagocytose complement-opsonized particles; neutrophil spreading on glass is attenuated in null neutrophils; these neutrophils also show a 60% reduction in the oxidative burst associated with phagocytosis
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• mutants show increased eosinophil accumulation at 10.5 hours, 48 hours and 5 days in the model of peritonitis
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• null animals have 2-fold more neutrophils in the peritoneal exudates after 2 hours in an experimental model of peritonitis than did wild-type animals
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgamtm1Myd mutation
(1 available);
any
Itgam mutation
(47 available)
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nervous system
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• after 3 hours of focal ischemia and 21 hours of reperfusion, infarct volume in wild-type mice is 79.4 cubic mm versus 58.9 cubic mm in homozygous animals (26% reduction in tissue injury)
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hematopoietic system
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• reduction in infarct size is accompanied by a 50% reduction in neutrophils in the periphery of the infarct area, although this is not statistically significant
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immune system
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• reduction in infarct size is accompanied by a 50% reduction in neutrophils in the periphery of the infarct area, although this is not statistically significant
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homeostasis/metabolism
immune system
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• S. aureus-infected mice exhibit an increased in viable S. aureus compared to in similarly treated wild-type mice
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hematopoietic system
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• S. aureus-infected mice exhibit an increased in viable S. aureus compared to in similarly treated wild-type mice
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Analysis Tools