All Phenotypes F5<tm2Dgi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

F5^tm2Dgi
targeted mutation 2, David Ginsburg
MGI:1931528

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	F5^tm2Dgi/F5^tm2Dgi	129S1.129(Cg)F5^tm2Dgi Tfpi^tm1Gjb	MGI:6119622
hm2	F5^tm2Dgi/F5^tm2Dgi	B6.129S2-F5^tm2Dgi	MGI:3588767
hm3	F5^tm2Dgi/F5^tm2Dgi	B6.129S2-F5^tm2Dgi/J	MGI:6275050
hm4	F5^tm2Dgi/F5^tm2Dgi	involves: 129S2/SvPas * C57BL/6	MGI:3789952
hm5	F5^tm2Dgi/F5^tm2Dgi	involves: 129S2/SvPas * C57BL/6J	MGI:3588765
ht6	F5^tm2Dgi/F5⁺	B6.129S2-F5^tm2Dgi	MGI:3588766
cx7	F5^tm2Dgi/F5^tm2Dgi Tfpi^tm1Gjb/Tfpi⁺	129S1.129(Cg)F5^tm2Dgi Tfpi^tm1Gjb	MGI:6119623
cx8	Actr2^MF5L12/Actr2⁺ F5^tm2Dgi/F5^tm2Dgi Tfpi^tm1Gjb/Tfpi⁺	involves: 129S1/Sv * 129S2/SvPas * C57BL/6	MGI:6119625
cx9	F5^tm2Dgi/F5^tm2Dgi MF5L6/MF5L6⁺ Tfpi^tm1Gjb/Tfpi⁺	involves: 129S1/Sv * 129S2/SvPas * C57BL/6	MGI:6119624
cx10	F5^tm2Dgi/F5^tm2Dgi Serpina10^tm1Gjb/Serpina10^tm1Gjb	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3804660
cx11	F5^tm2Dgi/F5⁺ Serpina10^tm1Gjb/Serpina10^tm1Gjb	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3804661
cx12	F5^tm2Dgi/F5^tm2Dgi Proz^tm1Gjb/Proz^tm1Gjb	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3789949
cx13	F5^tm2Dgi/F5⁺ Proz^tm1Gjb/Proz^tm1Gjb	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3789948
cx14	F5^tm2Dgi/F5^tm2Dgi Proz^tm1Gjb/Proz⁺	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3789950

Allelic Composition	F5^tm2Dgi/F5^tm2Dgi
Genetic Background	129S1.129(Cg)F5^tm2Dgi Tfpi^tm1Gjb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:244506 )

• Background Sensitivity: mice on a congenic 129S1 background exhibit decreased survival compared with mice on a congenic C57BL/6 background

Allelic Composition	F5^tm2Dgi/F5^tm2Dgi
Genetic Background	B6.129S2-F5^tm2Dgi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:66260 )

• Background Sensitivity: do not observe postnatal lethality on the predominately C57BL/6J background like on the mixed 129 and C57BL/6J background, however crossing back to 129/SvJ or 129SvIm/J mice, results in about 50% postnatal loss

homeostasis/metabolism

abnormal blood coagulation ( J:66260 )

• chronic, low-grade thrombin generation leading to enhanced fibrin deposition in multiple tissues, however do not observe thrombosis

liver/biliary system

liver fibrosis ( J:66260 )

• occasional focal hepatic fibrosis is seen

Allelic Composition	F5^tm2Dgi/F5^tm2Dgi
Genetic Background	B6.129S2-F5^tm2Dgi/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:244506 )

• Background Sensitivity: mice on a congenic C57BL/6 background exhibit increased survival compared with mice on a congenic 129S1 background

Allelic Composition	F5^tm2Dgi/F5^tm2Dgi
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:62716 )

• around 20% of homozygotes die in neonatal period

homeostasis/metabolism

abnormal thrombosis ( J:62716 )

• homozygotes that die show microvascular thrombosis in neonatal period

Allelic Composition	F5^tm2Dgi/F5^tm2Dgi
Genetic Background	involves: 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:66260 )

N	• Background Sensitivity: decreased number of expected pups at 3 weeks of age but not at 1-2 days before birth, however do not observe lethality on a predominately C57BL/6J background

homeostasis/metabolism

abnormal blood coagulation ( J:66260 )

• more resistant to anticoagulant activated protein C than controls or heterozygotes, however F5 clotting activity is normal

abnormal thrombosis ( J:66260 )

• Background Sensitivity: widespread thrombosis affecting multiple organs, including brain, liver, heart, pancreas, and spleen, in all newborns

behavior/neurological

lethargy ( J:66260 )

• subset of mice appear lethargic at birth

integument

pallor ( J:66260 )

• subset of mice appear pale at birth

Allelic Composition	F5^tm2Dgi/F5⁺
Genetic Background	B6.129S2-F5^tm2Dgi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:66260 )

• more resistant to anticoagulant activated protein C than controls, however F5 clotting activity is normal

abnormal thrombosis ( J:66260 )

• exhibit occasional spontaneous vascular thrombosis (e.g. necrosis of a digit)

Allelic Composition	F5^tm2Dgi/F5^tm2Dgi Tfpi^tm1Gjb/Tfpi⁺
Genetic Background	129S1.129(Cg)F5^tm2Dgi Tfpi^tm1Gjb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)
Tfpi^tm1Gjb mutation (0 available); any Tfpi mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:244506 )

• no mice are present at weaning

Allelic Composition	Actr2^MF5L12/Actr2⁺ F5^tm2Dgi/F5^tm2Dgi Tfpi^tm1Gjb/Tfpi⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actr2^MF5L12 mutation (0 available); any Actr2 mutation (37 available)
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)
Tfpi^tm1Gjb mutation (0 available); any Tfpi mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

abnormal survival ( J:244506 )

• mice exhibit increased survival compared with mice lacking the Actr2^mf5l12 mutation

Allelic Composition	F5^tm2Dgi/F5^tm2Dgi MF5L6/MF5L6⁺ Tfpi^tm1Gjb/Tfpi⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)
MF5L6 mutation (0 available); any MF5L6 mutation (0 available)
Tfpi^tm1Gjb mutation (0 available); any Tfpi mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:244506 )

• with fewer male than female mice, but less severe mortality than in mice lacking the MF5L6 mutation

Allelic Composition	F5^tm2Dgi/F5^tm2Dgi Serpina10^tm1Gjb/Serpina10^tm1Gjb
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)
Serpina10^tm1Gjb mutation (0 available); any Serpina10 mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:136102 )

• no mice survive until 6 weeks of age

• only 4% of embryos out of an expected 25% live until E18.5 with this genotype, which is significantly different from the normal number of E18.5 embryos found with a Proz^tm1Gjb / Proz^tm1Gjb F5^tm2Dgi / F5^tm2Dgi genotype

• normal numbers of double homozygotes are found at E13.5

cardiovascular system

hemoperitoneum ( J:136102 )

• is often observed in E13.5 embryos

intracranial hemorrhage ( J:136102 )

• is often observed in E13.5 embryos

nervous system

intracranial hemorrhage ( J:136102 )

• is often observed in E13.5 embryos

Allelic Composition	F5^tm2Dgi/F5⁺ Serpina10^tm1Gjb/Serpina10^tm1Gjb
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased survivor rate ( J:136102 )

• only 18% of mice with this genotype are found at 6 weeks of age instead of the expected 25% based on Mendelian inheritance

Allelic Composition	F5^tm2Dgi/F5^tm2Dgi Proz^tm1Gjb/Proz^tm1Gjb
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)
Proz^tm1Gjb mutation (0 available); any Proz mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:62716 )

• mortality of double homozygotes is high; only 1 animal reached adulthood (6 weeks)

cardiovascular system

hemorrhage ( J:62716 )

• at E17.5-18.5, almost all mutants show signs of hemorrhage

homeostasis/metabolism

abnormal thrombosis ( J:62716 )

• at E17.5-18.5, embryos display thrombosis and fibrin depositon in the vasculature

Allelic Composition	F5^tm2Dgi/F5⁺ Proz^tm1Gjb/Proz^tm1Gjb
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:62716 )

• fewer (only 10% of expected 50%) animals of this genotype are found at 6 weeks

Allelic Composition	F5^tm2Dgi/F5^tm2Dgi Proz^tm1Gjb/Proz⁺
Genetic Background	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:62716 )

• fewer (37% of expected 50%) animals of this genotype are found at 6 weeks

homeostasis/metabolism

abnormal thrombosis ( J:62716 )

• less severe than in double homozygous embryos

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