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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
H2-K1tm1Bpe
targeted mutation 1, Beatrice Perarnau
MGI:1931444
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
H2-K1tm1Bpe/H2-K1tm1Bpe involves: 129P2/OlaHsd * C57BL/6 MGI:3623452
cx2
H2-D1tm1Bpe/H2-D1tm1Bpe
H2-K1tm1Bpe/H2-K1tm1Bpe
B6.129P-H2-D1tm1Bpe H2-K1tm1Bpe MGI:3701875
cx3
H2-D1tm1Bpe/H2-D1tm1Bpe
H2-K1tm1Bpe/H2-K1tm1Bpe
X/Yaa
BXSB.129P2(B6)-H2-K1tm1Bpe H2-D1tm1Bpe/Dcr MGI:6094247
cx4
H2-D1tm1Bpe/H2-D1tm1Bpe
H2-K1tm1Bpe/H2-K1tm1Bpe
Klra1tm1.1Wyok/Klra1tm1.1Wyok
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac MGI:6196216
cx5
H2-D1tm1Bpe/H2-D1tm1Bpe
H2-K1tm1Bpe/H2-K1tm1Bpe
Klra1tm1.1Wyok/Klra1tm1.1Wyok
Tg(H2-Dd)28Bee/0
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac * DBA/2 MGI:6196218
cx6
H2-D1tm1Bpe/H2-D1tm1Bpe
H2-K1tm1Bpe/H2-K1tm1Bpe
involves: 129P2/OlaHsd * C57BL/6 MGI:3623453


Genotype
MGI:3623452
hm1
Allelic
Composition
H2-K1tm1Bpe/H2-K1tm1Bpe
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-K1tm1Bpe mutation (9 available); any H2-K1 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• numbers increase in parallel to decrease in CD8+ cells
• 30-50% reduction of single positive CD8 peripheral T-cells

hematopoietic system
• numbers increase in parallel to decrease in CD8+ cells
• 30-50% reduction of single positive CD8 peripheral T-cells




Genotype
MGI:3701875
cx2
Allelic
Composition
H2-D1tm1Bpe/H2-D1tm1Bpe
H2-K1tm1Bpe/H2-K1tm1Bpe
Genetic
Background
B6.129P-H2-D1tm1Bpe H2-K1tm1Bpe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1tm1Bpe mutation (9 available); any H2-D1 mutation (36 available)
H2-K1tm1Bpe mutation (9 available); any H2-K1 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in infected mutants, an enhanced H2-M3/LemA-specific response compared to wild-type is detected after injection of B6 splenocytes pulsed with this peptide
• number of H2-M3/LemA-specific CD8+ T cells is drastically increased compared to wild-type during primary LM infection

hematopoietic system
• in infected mutants, an enhanced H2-M3/LemA-specific response compared to wild-type is detected after injection of B6 splenocytes pulsed with this peptide
• number of H2-M3/LemA-specific CD8+ T cells is drastically increased compared to wild-type during primary LM infection




Genotype
MGI:6094247
cx3
Allelic
Composition
H2-D1tm1Bpe/H2-D1tm1Bpe
H2-K1tm1Bpe/H2-K1tm1Bpe
X/Yaa
Genetic
Background
BXSB.129P2(B6)-H2-K1tm1Bpe H2-D1tm1Bpe/Dcr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1tm1Bpe mutation (9 available); any H2-D1 mutation (36 available)
H2-K1tm1Bpe mutation (9 available); any H2-K1 mutation (52 available)
Yaa mutation (18 available); any Yaa mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• while BXSB/MpJ males have a mean survival of 32 weeks before dying from SLE-like syndrome, the additional absence of MHC class I molecules intensifies the severity to a mean survival of only 25 weeks of age

mortality/aging




Genotype
MGI:6196216
cx4
Allelic
Composition
H2-D1tm1Bpe/H2-D1tm1Bpe
H2-K1tm1Bpe/H2-K1tm1Bpe
Klra1tm1.1Wyok/Klra1tm1.1Wyok
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1tm1Bpe mutation (9 available); any H2-D1 mutation (36 available)
H2-K1tm1Bpe mutation (9 available); any H2-K1 mutation (52 available)
Klra1tm1.1Wyok mutation (0 available); any Klra1 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• total number of NK cells, number of Ly49A+ NK cells, and their maturation profile as indicated by CD27 and CD11b expression
• NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1




Genotype
MGI:6196218
cx5
Allelic
Composition
H2-D1tm1Bpe/H2-D1tm1Bpe
H2-K1tm1Bpe/H2-K1tm1Bpe
Klra1tm1.1Wyok/Klra1tm1.1Wyok
Tg(H2-Dd)28Bee/0
Genetic
Background
involves: 129P2/OlaHsd * BALB/cJ * C57BL/6NTac * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1tm1Bpe mutation (9 available); any H2-D1 mutation (36 available)
H2-K1tm1Bpe mutation (9 available); any H2-K1 mutation (52 available)
Klra1tm1.1Wyok mutation (0 available); any Klra1 mutation (14 available)
Tg(H2-Dd)28Bee mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• total number of NK cells, number of Ly49A+ NK cells, and their maturation profile as indicated by CD27 and CD11b expression
• NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1, compared above 1 in same strain with wild-type Klra1 allele (MGI:6196216)
• substantially increased percentage of Ly49A+ NK cells expressing L49G2, Ly49F and Ly49I, versus reduced percentage in same strain with wild-type Klra1 allele (MGI:6196216)

immune system
• NK cell licensing ratio (% Ifng+ Ly49+ versus Ifng+ Ly49- NK cells) lower than 1 as indicated by Ifng production after stimulation with anti-NK1.1, compared above 1 in same strain with wild-type Klra1 allele (MGI:6196216)
• substantially increased percentage of Ly49A+ NK cells expressing L49G2, Ly49F and Ly49I, versus reduced percentage in same strain with wild-type Klra1 allele (MGI:6196216)




Genotype
MGI:3623453
cx6
Allelic
Composition
H2-D1tm1Bpe/H2-D1tm1Bpe
H2-K1tm1Bpe/H2-K1tm1Bpe
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-D1tm1Bpe mutation (9 available); any H2-D1 mutation (36 available)
H2-K1tm1Bpe mutation (9 available); any H2-K1 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• survive infection with Lymphocytic Choriomeningitis Virus

immune system
• numbers increase in parallel to decrease in CD8+ cells
• 90% reduction of single positive CD8 peripheral T-cells
• CD8+ TCRalpha/beta T-cells not present
• survive infection with Lymphocytic Choriomeningitis Virus

nervous system
N
• normal gross cerebellar development
• increased glutamate transients in climbing fiber synaptic clefts
• lower threshold for induction if climbing fibers are involved in induction
• larger paired pulse ratio when paired stimuli are applied to climbing fibers are separated by 50-100 msec
• significantly increased second excitatory postsynaptic current

behavior/neurological
• performance in rotarod tests is significantly better than controls on the third day of testing
• testing repeated after 2 weeks of rest and then after another 4 months of rest indicate much better task retention than for controls

hematopoietic system
• numbers increase in parallel to decrease in CD8+ cells
• 90% reduction of single positive CD8 peripheral T-cells
• CD8+ TCRalpha/beta T-cells not present





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory