• mice exhibit normal susceptibility to MOG induced experimental autoimmune encephalomyelitis and response to treatment with dexamethasone (J:137157)

• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1^tm2Gsc control cells

• following exposure to MOG, mice exhibit earlier induction of experimental autoimmune encephalomyelitis than in similarly treated wild-type mice and fail to recover after treatment with dexamethasone as do Nr3c1^tm2Gsc control mice

• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1^tm2Gsc control cells

• following induction of experimental autoimmune encephalomyelitis and treatment with dexamethasone, regulatory T cell numbers are not as diminished as in Nr3c1^tm2Gsc control mice and expression of Foxp3 is unaltered

• unlike in peripheral T cells from Nr3c1^tm2Gsc control mice, treatment with dexamethasone does not reduced expression of cell adhesion molecules

• T cells fail to exhibit an increase in apoptosis following treatment with dexamethasone unlike Nr3c1^tm2Gsc control cells

• bone formation rate with prednisolone treatment for 2 weeks is reduced in mutants and controls (J:160669)

• reduced body weight starting around 3 weeks of age

• reduced body weight starting around 3 weeks of age

• mutant and control mice show similar acquisition and motivation to self-administer cocaine (J:150544)

• spontaneous activity (firing rates) of dopamine neurons in the ventral tegmental area (VTA) is similar to controls (J:150544)

• circulating glucocorticoid levels are normal under basal and stress conditions (J:150544)

• Anxiety-related behavior, basic motor processes (movement, coordination), and associative learning are not impaired in mutants (J:150544)

• mice show profoundly decreased cocaine self-administration; acquistion of cocaine self-administration is similar to controls but dose-response is decreased indicating a lower reinforcing efficacy of cocaine

• spontaneous firing rate of dopamine neurons is highly reduced in ventral tegmental area (VTA)

• circulating glucocorticoid levels are normal under basal and stress conditions (J:150544)

• anxiety-related behaviors are not altered compared to controls indicating behavioral changes are specific to cocaine reinforcement (J:150544)

• spontaneous firing rate of dopamine neurons is highly reduced in ventral tegmental area (VTA)

• impaired stress response in Porsolt forced-swim test; mice show normal immobility scores in an initial test, but do not show an increased response in a 24-hour restest

• in a light-dark crossing task test, mice exhibit a reduced latentcy in entering an aversive bright compartment and spent more time there

• in a zero-maze test, mice demonstrated an increased number of entries into the averse open segment and spent more time there

• mice are 82+/-0.4% of the length of control mice at 6-14 weeks of age

• mice are 70+/-3% of the weight of control mice at 6-14 weeks of age

• bone density is reduced in the skull and pelvis bones

• a displacement of fat tissue towards the head and neck from the rest of the body is apparent

• mice are not obese

• the morphology of the adrenal glands is similar to controls (J:57315)

• levels of adrenaline and noradrenaline in the adrenal glands is similar to controls (J:57315)

• morning levels of circulating glucocorticoids are elevated

• normal circadian rhythm is maintained

• plasma levels of ACTH are moderately reduced

• in the anterior pituitary, an increase in the level of ACTH and its transcript levels are seen

• elevation of CRH peptide levels in the paraventricular nucleus of the hypothalamus (PVN)

• no change in the level of vasopression (AVP)

• between day 14.5 of pregnancy (P14.5) and P18.5, lobuloalveolar development was retarded, however milk protein expression is normal and females are able to nurse pups although pups weight 20% less during the first 10 days after birth (J:95548)

• decreased cell proliferation in P14.5 mammary glands and increased cell proliferation in lactating (L0.5) mammary glands, however did not observe any differences in apoptosis during pregnancy (J:95548)

• although secretory alveoli form, less space is occupied by epithelial structures and more space is occupied by fat compared to controls during pregnancy and throughout lactation indicating that alveolar lobes do not completely penetrate the mammary fat pad (J:95548)

• between day 14.5 of pregnancy (P14.5) and P18.5, lobuloalveolar development was retarded, however milk protein expression is normal and females are able to nurse pups although pups weight 20% less during the first 10 days after birth (J:95548)

• decreased cell proliferation in P14.5 mammary glands and increased cell proliferation in lactating (L0.5) mammary glands, however did not observe any differences in apoptosis during pregnancy (J:95548)

• between day 14.5 of pregnancy (P14.5) and P18.5, lobuloalveolar development was retarded, however milk protein expression is normal and females are able to nurse pups although pups weight 20% less during the first 10 days after birth (J:95548)

• decreased cell proliferation in P14.5 mammary glands and increased cell proliferation in lactating (L0.5) mammary glands, however did not observe any differences in apoptosis during pregnancy (J:95548)

• although secretory alveoli form, less space is occupied by epithelial structures and more space is occupied by fat compared to controls during pregnancy and throughout lactation indicating that alveolar lobes do not completely penetrate the mammary fat pad (J:95548)

• when treated with tamoxifen the level of serum corticosterone is increased to 39+/-8 ng/ml when one copies of the transgene is present, 100+/-20 ng/ml when two copies of the transgene are present and 108+/-19 ng/ml when four copies of the transgene are present compared to 13+/-5 ng/ml in wild-type

• males exhibit a slight increase in crown-rump length compared to controls at 10 weeks

• bone resorption is slightly decreased in both mutants and controls while osteoclast numbers are not affected (J:160669)

• calvarial osteoblasts exhibit diminished differentiation potential in terms of bone nodule formation and alkaline phosphatase expression

• with prednisolone treatment, osteoblast differentiation is impaired in wild-type mice, but is unaffected in mutants, as determined by Col1a1 expression, marking functional osteoblasts

• in response to two weeks of treatment with the Nr3c1 agonist prednisolone, mutants do not display reduced bone mineral density in vertebral bones in contrast to treated controls

• mice show modest but highly significant decrease in bone density in calcified vertebral sections compared to controls at 3 months

• trabecular numbers are decreased but trabecular thickness is unaltered resulting in increased trabecular spacing

• osteoblast numbers, osteoblast surface, osteocytes, and osteoclast parameters are not significantly changed compared to controls

• bone formation in vertebrae is not inhibited whereas treated controls show near complete inhibition of bone formation with prednisolone treatment; osteoblastogenesis (numbers of colony forming units of osteoblasts) is not impaired as seen in controls with prednisolone treatment

• calvarial osteoblasts exhibit diminished differentiation potential in terms of bone nodule formation and alkaline phosphatase expression

• with prednisolone treatment, osteoblast differentiation is impaired in wild-type mice, but is unaffected in mutants, as determined by Col1a1 expression, marking functional osteoblasts

• reduced body weight starting around 3 weeks of age