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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Vegfatm1Gne
targeted mutation 1, Genentech
MGI:1931041
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Vegfatm1Gne/Vegfa+ involves: 129S2/SvPas * C57BL/6J MGI:2174800


Genotype
MGI:2174800
ht1
Allelic
Composition
Vegfatm1Gne/Vegfa+
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfatm1Gne mutation (0 available); any Vegfa mutation (37 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• heterozygotes die between E11 and E12

embryo
• at E10.5, mutant placentas exhibit a condensed vasculature with a degenerating endothelium lining the fetal capillaries
• at E9.5-E11.5, several heterozygotes display an apparent absence of blood supply in the yolk sac
• at E9.5-E11.5, vitelline veins fail to fuse with the yolk sac
• at E11.5, heterozygus mutant embryos exhibit significant apoptosis, consistent with a vascular deficit
• at E9.5-E12.5, heterozygotes display poorly developed and unsegmented branchial arches in the cranial region
• at E9.5-E11.5, the forelimb buds of heterozygotes are abnormally located at the earlier caudal position and appear unsegmented
• at E9.5-E11.5, heterozygotes show significantly less nucleated red blood cells in the blood islands

cardiovascular system
• at E10.5, heterozygotes display abnormal vascular patterns in the placenta and forebrain
• at E9.5-E11.5, heterozygotes exhibit a rudimentary dorsal aorta
• at E10.5, mutant placentas exhibit a condensed vasculature with a degenerating endothelium lining the fetal capillaries
• at E9.5-E11.5, several heterozygotes display an apparent absence of blood supply in the yolk sac
• at E9.5-E11.5, vitelline veins fail to fuse with the yolk sac
• at E9.5-E11.5, the common atrium and primitive ventricle are developmentally delayed
• at E10.5, heterozygotes show lack of myoblast differentiation in the cardiac region
• at E9.5-E11.5, heterozygotes show a significantly thinned ventricular wall

nervous system
• at E10.5, heterozygotes exhibit increased apoptosis and disorganization of neuroepithelial cells
• at E9.5-E11.5, heterozygotes display an underdeveloped forebrain region with vascular elements present in the mesenchyme but not in the neuroepithelium

limbs/digits/tail
• at E9.5-E11.5, the forelimb buds of heterozygotes are abnormally located at the earlier caudal position and appear unsegmented

craniofacial
• at E9.5-E12.5, heterozygotes display poorly developed and unsegmented branchial arches in the cranial region

cellular
• at E11.5, heterozygus mutant embryos exhibit significant apoptosis, consistent with a vascular deficit
• at E10.5, heterozygotes exhibit increased apoptosis and disorganization of neuroepithelial cells





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory