Mouse Genome Informatics
cx1
    Tg(K6ODCtr)55Tgo/0
Trp53tm1Tyj/Trp53tm1Tyj

involves: 129S2/SvPas * C3H * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cellular
N
• in culture, primary keratinocytes exhibit normal life span (J:133302)


Mouse Genome Informatics
tg2
    Tg(K6ODCtr)55Tgo/0
C57BL/6-Tg(K6ODCtr)55Tgo/J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
adipose tissue
• in older mice, dermal cysts replace the subcutaneous fat layer

growth/size

endocrine/exocrine glands
• sebaceous glands are moderately hyperplastic

integument
• in older mice, dermal cysts replace the subcutaneous fat layer
• sebaceous glands are moderately hyperplastic
• by 1.5 months of age, mice exhibit generalized hair loss
• cysts replace the lower portion of the hair follicle
• mice exhibit a dilatation of the hair follicle infundibulum
• disintegration of the lower portion of the hair follicle
• mice exhibit excessive nail growth
• by 1.5 months of age
• cysts replace the lower portion of the hair follicle
• some cysts have thick walls of stratified squamous epithelium filled with concentrically oriented cornified squames
• in older mice, dermal cysts replace the subcutaneous fat layer
• some cysts rupture and form foreign body granulomas
• mice exhibit comedo-like structures associated with sebaceous glands
• as mice age their skin exhibits excessive growth resulting in wrinkling and folding

Mouse Models of Human Disease
OMIM IDRef(s)
Atrichia with Papular Lesions; APL 209500 J:62356


Mouse Genome Informatics
tg3
    Tg(K6ODCtr)55Tgo/0
involves: C3H * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
adipose tissue
• after three months of age, dermal cysts replace the subcutaneous fat layer

growth/size

cellular
• in culture, primary keratinocytes undergo premature cell death via apoptosis compared to wild-type cells
• increased cell density prolongs primary keratinocyte cell life in culture but does not prevent premature death
• however, treatment with DFMO blocks cell death in cultured primary keratinocytes

tumorigenesis
• mice develop skin tumors (squamous neoplasms) at a higher rate than wild-type mice
• however, squamous cell carcinomas are not observed
• mice develop keratoacanthom-like lesions and well-differentiated papillomatous lesions
• skin tumors are found on the tail, face and ears

endocrine/exocrine glands
• sebaceous glands near dermal cysts are moderately hyperplastic

integument
• after three months of age, dermal cysts replace the subcutaneous fat layer
• sebaceous glands near dermal cysts are moderately hyperplastic
• despite a normal first hair cycle, mice exhibit hair loss at 2 to 3 weeks of age
• mice exhibit complete hair loss by 2 months of age
• hair loss is a dominant phenotype
• after 2 months of age
• mice exhibit excessive nail growth
• by 2 months of age
• mice exhibit follicular cysts in the dermis
• in mice older than 3 months, cysts are very large and replace the subcutaneous fat layer
• develops with age
• mice develop keratoacanthom-like lesions
• develops with age
• mice develop skin tumors (squamous neoplasms) at a higher rate than wild-type mice
• however, squamous cell carcinomas are not observed
• mice develop keratoacanthom-like lesions and well-differentiated papillomatous lesions
• skin tumors are found on the tail, face and ears