Analysis Tools
cellular
| N |
• in culture, primary keratinocytes exhibit normal life span
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Allele Symbol Allele Name Allele ID |
Tg(K6ODCtr)55Tgo transgene insertion 55, Thomas O'Brien MGI:1930206 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• in culture, primary keratinocytes exhibit normal life span
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in older mice, dermal cysts replace the subcutaneous fat layer
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• at birth
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• cysts replace the lower portion of the hair follicle
• some cysts have thick walls of stratified squamous epithelium filled with concentrically oriented cornified squames
• in older mice, dermal cysts replace the subcutaneous fat layer
• some cysts rupture and form foreign body granulomas
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• sebaceous glands are moderately hyperplastic
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• in older mice, dermal cysts replace the subcutaneous fat layer
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• sebaceous glands are moderately hyperplastic
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• cysts replace the lower portion of the hair follicle
• some cysts have thick walls of stratified squamous epithelium filled with concentrically oriented cornified squames
• in older mice, dermal cysts replace the subcutaneous fat layer
• some cysts rupture and form foreign body granulomas
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• by 1.5 months of age, mice exhibit generalized hair loss
• cysts replace the lower portion of the hair follicle
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• mice exhibit excessive nail growth
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• mice exhibit a dilatation of the hair follicle infundibulum
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• mice exhibit comedo-like structures associated with sebaceous glands
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• disintegration of the lower portion of the hair follicle
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• by 1.5 months of age
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• as mice age their skin exhibits excessive growth resulting in wrinkling and folding
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| atrichia with papular lesions | DOID:0060689 |
OMIM:209500 |
J:62356 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after three months of age, dermal cysts replace the subcutaneous fat layer
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• at birth
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• mice exhibit follicular cysts in the dermis
• in mice older than 3 months, cysts are very large and replace the subcutaneous fat layer
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• in culture, primary keratinocytes undergo premature cell death via apoptosis compared to wild-type cells
• increased cell density prolongs primary keratinocyte cell life in culture but does not prevent premature death
• however, treatment with DFMO blocks cell death in cultured primary keratinocytes
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• mice develop skin tumors (squamous neoplasms) at a higher rate than wild-type mice
• however, squamous cell carcinomas are not observed
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• mice develop keratoacanthoma-like lesions
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• mice develop well-differentiated papillomatous lesions
• skin tumors are found on the tail, face and ears
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• sebaceous glands near dermal cysts are moderately hyperplastic
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• after three months of age, dermal cysts replace the subcutaneous fat layer
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• in culture, primary keratinocytes undergo premature cell death via apoptosis compared to wild-type cells
• increased cell density prolongs primary keratinocyte cell life in culture but does not prevent premature death
• however, treatment with DFMO blocks cell death in cultured primary keratinocytes
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• sebaceous glands near dermal cysts are moderately hyperplastic
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• mice exhibit follicular cysts in the dermis
• in mice older than 3 months, cysts are very large and replace the subcutaneous fat layer
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• despite a normal first hair cycle, mice exhibit hair loss at 2 to 3 weeks of age
• mice exhibit complete hair loss by 2 months of age
• hair loss is a dominant phenotype
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• mice exhibit excessive nail growth
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• after 2 months of age
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• by 2 months of age
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• develops with age
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• mice develop skin tumors (squamous neoplasms) at a higher rate than wild-type mice
• however, squamous cell carcinomas are not observed
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• mice develop keratoacanthoma-like lesions
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• mice develop well-differentiated papillomatous lesions
• skin tumors are found on the tail, face and ears
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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