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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(K6ODCtr)55Tgo
transgene insertion 55, Thomas O'Brien
MGI:1930206
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(K6ODCtr)55Tgo/0
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S2/SvPas * C3H * C57BL/6 MGI:3799500
tg2
Tg(K6ODCtr)55Tgo/0 C57BL/6-Tg(K6ODCtr)55Tgo/J MGI:3799519
tg3
Tg(K6ODCtr)55Tgo/0 involves: C3H * C57BL/6 MGI:3799477


Genotype
MGI:3799500
cx1
Allelic
Composition
Tg(K6ODCtr)55Tgo/0
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129S2/SvPas * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(K6ODCtr)55Tgo mutation (2 available)
Trp53tm1Tyj mutation (9 available); any Trp53 mutation (145 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
N
• in culture, primary keratinocytes exhibit normal life span




Genotype
MGI:3799519
tg2
Allelic
Composition
Tg(K6ODCtr)55Tgo/0
Genetic
Background
C57BL/6-Tg(K6ODCtr)55Tgo/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(K6ODCtr)55Tgo mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• in older mice, dermal cysts replace the subcutaneous fat layer

growth/size/body

endocrine/exocrine glands
• sebaceous glands are moderately hyperplastic

integument
• in older mice, dermal cysts replace the subcutaneous fat layer
• sebaceous glands are moderately hyperplastic
• by 1.5 months of age, mice exhibit generalized hair loss
• cysts replace the lower portion of the hair follicle
• mice exhibit a dilatation of the hair follicle infundibulum
• mice exhibit comedo-like structures associated with sebaceous glands
• disintegration of the lower portion of the hair follicle
• mice exhibit excessive nail growth
• by 1.5 months of age
• cysts replace the lower portion of the hair follicle
• some cysts have thick walls of stratified squamous epithelium filled with concentrically oriented cornified squames
• in older mice, dermal cysts replace the subcutaneous fat layer
• some cysts rupture and form foreign body granulomas
• as mice age their skin exhibits excessive growth resulting in wrinkling and folding

Mouse Models of Human Disease
OMIM ID Ref(s)
Atrichia with Papular Lesions; APL 209500 J:62356




Genotype
MGI:3799477
tg3
Allelic
Composition
Tg(K6ODCtr)55Tgo/0
Genetic
Background
involves: C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(K6ODCtr)55Tgo mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• after three months of age, dermal cysts replace the subcutaneous fat layer

growth/size/body

cellular
• in culture, primary keratinocytes undergo premature cell death via apoptosis compared to wild-type cells
• increased cell density prolongs primary keratinocyte cell life in culture but does not prevent premature death
• however, treatment with DFMO blocks cell death in cultured primary keratinocytes

neoplasm
• mice develop skin tumors (squamous neoplasms) at a higher rate than wild-type mice
• however, squamous cell carcinomas are not observed
• mice develop keratoacanthoma-like lesions
• mice develop well-differentiated papillomatous lesions
• skin tumors are found on the tail, face and ears

endocrine/exocrine glands
• sebaceous glands near dermal cysts are moderately hyperplastic

integument
• after three months of age, dermal cysts replace the subcutaneous fat layer
• in culture, primary keratinocytes undergo premature cell death via apoptosis compared to wild-type cells
• increased cell density prolongs primary keratinocyte cell life in culture but does not prevent premature death
• however, treatment with DFMO blocks cell death in cultured primary keratinocytes
• sebaceous glands near dermal cysts are moderately hyperplastic
• despite a normal first hair cycle, mice exhibit hair loss at 2 to 3 weeks of age
• mice exhibit complete hair loss by 2 months of age
• hair loss is a dominant phenotype
• after 2 months of age
• mice exhibit excessive nail growth
• by 2 months of age
• mice exhibit follicular cysts in the dermis
• in mice older than 3 months, cysts are very large and replace the subcutaneous fat layer
• develops with age
• develops with age
• mice develop skin tumors (squamous neoplasms) at a higher rate than wild-type mice
• however, squamous cell carcinomas are not observed
• mice develop keratoacanthoma-like lesions
• mice develop well-differentiated papillomatous lesions
• skin tumors are found on the tail, face and ears





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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory