Phenotypes associated with this allele

• Allele Symbol: Ntf5^tm1Gdy
• Allele Name: targeted mutation 1, George D Yancopoulos
• Allele ID: MGI:1930044
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ntf5^tm1Gdy/Ntf5^tm1Gdy	involves: 129P2/OlaHsd	MGI:2175181
cx2	Bdnf^tm1Gdy/Bdnf^tm1Gdy Ntf5^tm1Gdy/Ntf5^tm1Gdy	involves: 129P2/OlaHsd	MGI:3655642

Genotype
MGI:2175181

hm1

• Allelic Composition: Ntf5^tm1Gdy/Ntf5^tm1Gdy
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased sensory neuron number ( J:25565 )

• homozygotes show a 61% reduction in the number of nodose-petrosal sensory neurons

• however, no reductions in the motor neurons of the facial nucleus or lumbar cord are observed

small petrosal ganglion ( J:25565 )

• homozygotes display an ~61% reduction in nodose-petrosal complex volume and neuronal number relative to wild-type mice

small nodose ganglion ( J:25565 )

• homozygotes display an ~61% reduction in nodose-petrosal complex volume and neuronal number relative to wild-type mice

• however, homozygotes are viable, fertile and behaviorally normal up to 10 months of age, with no apparent deficits in growth or righting responses

• in addition, vestibular, cochlear and trigeminal ganglia are not reduced in size, and brain size is grossly unaffected

Genotype
MGI:3655642

cx2

• Allelic Composition: Bdnf^tm1Gdy/Bdnf^tm1Gdy; Ntf5^tm1Gdy/Ntf5^tm1Gdy
• Genetic Background: involves: 129P2/OlaHsd

mortality/aging

postnatal lethality, complete penetrance ( J:25565 )

• double homozygotes die within 3 weeks of birth, similar to single Bdnf^tm1Gdy homozygotes

growth/size/body

postnatal growth retardation ( J:25565 )

• double homozygotes display postnatal growth disturbances similar to those observed in single Bdnf^tm1Gdy homozygotes

behavior/neurological

abnormal motor coordination/balance ( J:25565 )

• double homozygotes display behavioral defects similar to those observed in single Bdnf^tm1Gdy homozygotes

impaired righting response ( J:25565 )

hyperactivity ( J:25565 )

nervous system

decreased sensory neuron number ( J:25565 )

• double homozygotes show a 79% reduction in the number of nodose-petrosal sensory neurons

• however, no reductions in the motor neurons of the facial nucleus or lumbar cord are observed

small petrosal ganglion ( J:25565 )

• double homozygotes show a greater volume reduction in the nodose-petrosal complex (~83%, accompanied by a 79% reduction in neuronal number) relative to single Bdnf^tm1Gdy or Ntf5^tm1Gdy homozygotes (~68% and ~61% reductions, respectively)

small trigeminal ganglion ( J:25565 )

• double mutant trigeminal ganglia are reduced by ~34% in volume relative to wild-type

small nodose ganglion ( J:25565 )

• double homozygotes show a greater volume reduction in the nodose-petrosal complex (~83%, accompanied by a 79% reduction in neuronal number) relative to single Bdnf^tm1Gdy or Ntf5^tm1Gdy homozygotes (~68% and ~61% reductions, respectively)

small vestibular ganglion ( J:110692 )

• at P1, double homozygotes display a comparable reduction in vestibular ganglion size relative to single Bdnf^tm1Gdy homozygotes

• in contrast to vestibular ganglia, cochlear ganglia and cochlear structures appear normal