Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Par mutation
(0 available);
any
Bdnf mutation
(39 available)
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mortality/aging
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• die within 2 weeks of birth
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nervous system
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• increase in dorsal root ganglion neuron apoptosis
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• delay in barrel formation through P6, but the deficiency disappears by P8
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• innervation into layer IV of the cortex by thalamic axons is uniform (rather than segregated into individual barrels) at P6, but becomes less apparent by P8
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• reduction of neurons in sensory ganglia, however motor neuron numbers are normal
(J:44286)
• majority of sensory neuron loss occurs before E13.5
(J:44286)
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• 50% reduction of neurons in the geniculate ganglion
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• 39% reduction of neurons in the nodose/petrosal ganglion
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• 21% reduction of neurons in the trigeminal ganglion
(J:44286)
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• 39% reduction of neurons in the nodose/petrosal ganglion
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• dorsal root ganglion neuronal cultures exhibit about 50% reduction in numbers of Bdnf and Ntf5-responsive neurons, but not of Ntf3-responsive neruons
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• 36% reduction of neurons in the L4 dorsal root ganglion
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• 31% reduction of dorsal root ganglion neurons by E13
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cellular
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• increase in dorsal root ganglion neuron apoptosis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Par mutation
(0 available);
any
Bdnf mutation
(39 available)
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behavior/neurological
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• age-related increase in food intake beggining around 6 weeks of age
• by 4-7 months of age mice consume about 25% more food than wild-type littermates
• chronic fluoxetine treatment partially suppresses hyperphagia
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• decrease in latency to attack an intruder and increase in number of biting attacks
(J:59077)
• latency to attack progressively decreases over repeated trials
(J:59077)
• treatment with fluoxetine reduced aggression to a level similar to that in wild-type mice
(J:59077)
• male mice have decreased latency time to first biting attack against intruder males
compared to wild-type controls
(J:144845)
• male mice also have a significantly increased number of biting attacks over a 5 minute period
(J:144845)
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• increased time spent in the center area during a 10 minute period in and open field; however, overall locomotor activity in an open field is not different from wild-type
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• during a 10 minute trial in an open field
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growth/size/body
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• mice gain weight with age with a mean 10 gram difference occurring by 6 months of age
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• first detected at 2-4 months of age and by 12-18 months of age body weight is 34% higher than wild-type littermates
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nervous system
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• progressive loss of serotonin axons is seen in 12 to 18 month old mice
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• abnormal induction of Fos by dexfenfluramine (reduced in the bed nucleus of the stria terminalis, the central nucleus of the amygdala, parts of the caudate-putamen, the shell region of the nucleus accumbens, and the thalamic nuclei; increased in the pyramidal neurons of the hippocampus) indicates abnormal neuronal activation induced by 5-HT release
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homeostasis/metabolism
Allelic
Composition |
Bdnftm1Par/Bdnf+
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Genetic
Background |
involves: 129S1/Sv |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Par mutation
(0 available);
any
Bdnf mutation
(39 available)
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behavior/neurological
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• decreased exploratory behavior as measured by percentage of time spent in the center and number of entries into the center of and open field over a 2 hour period; however no significant change in total locomotor activity is detected
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• increase in intermale aggression
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• decrease in time spent in the open arms and numbers of entries into the open arms in an elevated plus maze
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nervous system
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• 13.8 +/- 0.6% reduction in hippocampal volume
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growth/size/body
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• first detected at 2 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Par mutation
(0 available);
any
Bdnf mutation
(39 available)
Ntrk2tm1.1Tes mutation
(0 available);
any
Ntrk2 mutation
(66 available)
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behavior/neurological
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• male mice have decreased latency time to first biting attack against intruder males compared to wild-type controls
• male mice also have a significantly increased number of biting attacks over a 5 minute period
• the latency time and number of attacks are not to the same degree as mice that only carry the Bdnftm1Par mutant allele
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growth/size/body
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• mice gain weight with age though not to the degree as mice that only carry the Bdnftm1Par mutant allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Par mutation
(0 available);
any
Bdnf mutation
(39 available)
Ntrk2tm1.1Tes mutation
(0 available);
any
Ntrk2 mutation
(66 available)
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behavior/neurological
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• male mice have decreased latency time to first biting attack against intruder males compared to wild-type controls
• male mice also have a significantly increased number of biting attacks over a 5 minute period
• the latency time and number of attacks are not to the same degree as mice that only carry the Bdnftm1Par mutant allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Par mutation
(0 available);
any
Bdnf mutation
(39 available)
Ntf3tm1Par mutation
(0 available);
any
Ntf3 mutation
(24 available)
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mortality/aging
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• die within the first day of birth
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nervous system
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• 100% reduction of neurons in the spiral ganglia
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• reduction of neurons in sensory ganglia, however motor neuron numbers are normal
• sensory neuron loss occurs from E12.5 to P0.5
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• 65% reduction of neurons in the geniculate ganglion
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• 62% reduction of neurons in the nodose/petrosal ganglion
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• 74% reduction of neurons in the trigeminal ganglion
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• 62% reduction of neurons in the nodose/petrosal ganglion
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• 100% reduction of neurons in the vestibular ganglia
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• 83% reduction of neurons in the L4 dorsal root ganglion
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bdnftm1Par mutation
(0 available);
any
Bdnf mutation
(39 available)
Ntf5tm1Par mutation
(0 available);
any
Ntf5 mutation
(12 available)
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nervous system
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• reduction in number of differentiated dorsal root ganglion neurons at E13, indicating delayed neuronal differentiation, however numbers of sensory neurons are normal
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• dorsal root ganglion neuronal cultures exhibit reduced numbers of Bdnf and Ntf5-responsive neurons and increased numbers of Ntf3-dependent neurons
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cellular
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• reduction in number of differentiated dorsal root ganglion neurons at E13, indicating delayed neuronal differentiation, however numbers of sensory neurons are normal
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Analysis Tools