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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Erbb2tm1Haus
targeted mutation 1, Christopher Hauser
MGI:1929070
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Erbb2tm1Haus/Erbb2tm1Haus involves: 129S4/SvJae * C57BL/6 MGI:2175863
ht2
Erbb2tm5(Erbb2)Mul/Erbb2tm1Haus involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c MGI:3522503
ht3
Erbb2tm6(Erbb2)Mul/Erbb2tm1Haus involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c MGI:3522575
ht4
Erbb2tm7(Erbb2)Mul/Erbb2tm1Haus involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c MGI:3522576
ht5
Erbb2tm4(Erbb2)Mul/Erbb2tm1Haus involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c MGI:3522502
cn6
Erbb2tm1Haus/Erbb2tm1Klee
Gfra1tm3Jmi/Gfra1+
Myf5tm3(cre)Sor/Myf5+
involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ MGI:4456175
cn7
Erbb2tm1Haus/Erbb2tm1Klee
Myf5tm3(cre)Sor/Myf5+
involves: 129S4/SvJae * C57BL/6 MGI:3843807


Genotype
MGI:2175863
hm1
Allelic
Composition
Erbb2tm1Haus/Erbb2tm1Haus
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Haus mutation (0 available); any Erbb2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryos die before E11

nervous system
• no motor neurons were detected in the r2-r3 region of developing mutant brains at E10.5
• no sensory neuron axons were detected in the r2-r3 region of developing mutant brains at E10.5
• the number of axons and cell bodies was reduced
• the dorsal portion and the mandibular branch were absent, although the maxillary and ophthalmic branches appeared normal
• proximal portion is smaller than in controls
• no axonal connections were detected in hindbrain
• proximal portion is smaller than in controls

cardiovascular system
• cardiac trabeculae were not found
• observed in some embryos, but the compact zone and outflow tract were normal

muscle
• cardiac trabeculae were not found




Genotype
MGI:3522503
ht2
Allelic
Composition
Erbb2tm5(Erbb2)Mul/Erbb2tm1Haus
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Haus mutation (0 available); any Erbb2 mutation (5 available)
Erbb2tm5(Erbb2)Mul mutation (0 available); any Erbb2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mutants are normal, healthy, and fertile




Genotype
MGI:3522575
ht3
Allelic
Composition
Erbb2tm6(Erbb2)Mul/Erbb2tm1Haus
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Haus mutation (0 available); any Erbb2 mutation (5 available)
Erbb2tm6(Erbb2)Mul mutation (0 available); any Erbb2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular

mortality/aging
• die shortly after birth struggling unsuccessfully to breathe

respiratory system

nervous system
• phrenic nerves are thinned, disorganized, and discontinuous or incomplete and they lack an apparent main nerve trunk from which smaller presynaptic branches originate
• diaphragm muscle is very poorly innervated by the phrenic nerve




Genotype
MGI:3522576
ht4
Allelic
Composition
Erbb2tm7(Erbb2)Mul/Erbb2tm1Haus
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Haus mutation (0 available); any Erbb2 mutation (5 available)
Erbb2tm7(Erbb2)Mul mutation (0 available); any Erbb2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular

mortality/aging
• die shortly after birth struggling unsuccessfully to breathe

respiratory system

nervous system
• phrenic nerves are thinned, disorganized, and discontinuous or incomplete and they lack an apparent main nerve trunk from which smaller presynaptic branches originate
• diaphragm muscle is very poorly innervated by the phrenic nerve




Genotype
MGI:3522502
ht5
Allelic
Composition
Erbb2tm4(Erbb2)Mul/Erbb2tm1Haus
Genetic
Background
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Haus mutation (0 available); any Erbb2 mutation (5 available)
Erbb2tm4(Erbb2)Mul mutation (0 available); any Erbb2 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular

mortality/aging
• although the expected numbers of mutants were present at birth, they were either stillborn or started dying immediately after birth

respiratory system
• cannot breathe despite the ability to open the mouth
• unable to inflate and expand lungs, despite the lungs being vascularized and structurally intact

homeostasis/metabolism

nervous system
• only partial development of the thoracic sympathetic ganglia at E12.5, with defects becoming more severe in a rostral-caudal gradient
• phrenic nerves are thinned, disorganized, and discontinuous or incomplete and they lack an apparent main nerve trunk from which smaller presynaptic branches originate
• diaphragm muscle is very poorly innervated by the phrenic nerve




Genotype
MGI:4456175
cn6
Allelic
Composition
Erbb2tm1Haus/Erbb2tm1Klee
Gfra1tm3Jmi/Gfra1+
Myf5tm3(cre)Sor/Myf5+
Genetic
Background
involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Haus mutation (0 available); any Erbb2 mutation (5 available)
Erbb2tm1Klee mutation (0 available); any Erbb2 mutation (5 available)
Gfra1tm3Jmi mutation (0 available); any Gfra1 mutation (5 available)
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the number of cholinergic motor neurons is decreased compared to in wild-type mice
• the number of cholinergic motor neurons is decreased compared to in wild-type mice
• mice exhibit a reduction in small Gfra1+ motor neurons compared with wild-type mice
• loss of gamma-motor neurons is intermediate to wild-type mice and Egr3tm1Jmi homozygotes
• mice exhibit a decrease in large diameter motor neurons compared with wild-type mice




Genotype
MGI:3843807
cn7
Allelic
Composition
Erbb2tm1Haus/Erbb2tm1Klee
Myf5tm3(cre)Sor/Myf5+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2tm1Haus mutation (0 available); any Erbb2 mutation (5 available)
Erbb2tm1Klee mutation (0 available); any Erbb2 mutation (5 available)
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice show a flexed posture when inverted
• mice exhibit a wide-based, ataxic gait

nervous system
• only rudimentary muscle spindles with a single Egr3-positive myofiber are seen in tibialis anterior muscles at P3 in contrast to spindles in controls which have multiple Egr3+ intrafusal myofibers
• on P4 muscle spindles, few mutant spindles have the complex annulospiral afferent terminal seen around the equatorial region of intrafusal myofibers in control muscle; muscle spindle afferent terminal morphology is simple compared to controls
• spindle development fails to progress beyond E18 and mature spindles do not form
• in tibialis anterior (TA) muscle, muscle spindle numbers are decreased 70% from those of controls
• innervation of muscle spindles is simpler than observed in controls, but spindle afferent projection to the ventral spinal cord shows normal pattern
• monosynaptic inputs from muscle spindle afferent to motor neurons are functional but reduced in amplitude; EPSPs evoked by dorsal root stimulation or evoked by muscle nerve stimulation are reduced from those of controls by similar amounts (to about 22-26% of wild-type amplitudes)

muscle
• only rudimentary muscle spindles with a single Egr3-positive myofiber are seen in tibialis anterior muscles at P3 in contrast to spindles in controls which have multiple Egr3+ intrafusal myofibers
• on P4 muscle spindles, few mutant spindles have the complex annulospiral afferent terminal seen around the equatorial region of intrafusal myofibers in control muscle; muscle spindle afferent terminal morphology is simple compared to controls
• spindle development fails to progress beyond E18 and mature spindles do not form
• in tibialis anterior (TA) muscle, muscle spindle numbers are decreased 70% from those of controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory