All Phenotypes Erbb2<tm1Haus> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Erbb2^tm1Haus
targeted mutation 1, Christopher Hauser
MGI:1929070

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Erbb2^tm1Haus/Erbb2^tm1Haus	involves: 129S4/SvJae * C57BL/6	MGI:2175863
ht2	Erbb2^{tm5(Erbb2)Mul}/Erbb2^tm1Haus	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c	MGI:3522503
ht3	Erbb2^{tm6(Erbb2)Mul}/Erbb2^tm1Haus	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c	MGI:3522575
ht4	Erbb2^{tm7(Erbb2)Mul}/Erbb2^tm1Haus	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c	MGI:3522576
ht5	Erbb2^{tm4(Erbb2)Mul}/Erbb2^tm1Haus	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c	MGI:3522502
cn6	Erbb2^tm1Haus/Erbb2^tm1Klee Gfra1^tm3Jmi/Gfra1⁺ Myf5^tm3(cre)Sor/Myf5⁺	involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ	MGI:4456175
cn7	Erbb2^tm1Haus/Erbb2^tm1Klee Myf5^tm3(cre)Sor/Myf5⁺	involves: 129S4/SvJae * C57BL/6	MGI:3843807

Allelic Composition	Erbb2^tm1Haus/Erbb2^tm1Haus
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Haus mutation (0 available); any Erbb2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:29973 )

• embryos die before E11

nervous system

abnormal motor neuron innervation pattern ( J:29973 )

• no motor neurons were detected in the r2-r3 region of developing mutant brains at E10.5

abnormal sensory neuron innervation pattern ( J:29973 )

• no sensory neuron axons were detected in the r2-r3 region of developing mutant brains at E10.5

abnormal cranial ganglia morphology ( J:29973 )

abnormal geniculate ganglion morphology ( J:29973 )

• the number of axons and cell bodies was reduced

abnormal trigeminal ganglion morphology ( J:29973 )

• the dorsal portion and the mandibular branch were absent, although the maxillary and ophthalmic branches appeared normal

abnormal cranial nerve morphology ( J:29973 )

abnormal glossopharyngeal nerve morphology ( J:29973 )

• proximal portion is smaller than in controls

abnormal trigeminal nerve morphology ( J:29973 )

• no axonal connections were detected in hindbrain

abnormal vagus nerve morphology ( J:29973 )

• proximal portion is smaller than in controls

cardiovascular system

absent myocardial trabeculae ( J:29973 )

• cardiac trabeculae were not found

decreased atrioventricular cushion size ( J:29973 )

• observed in some embryos, but the compact zone and outflow tract were normal

muscle

absent myocardial trabeculae ( J:29973 )

• cardiac trabeculae were not found

Allelic Composition	Erbb2^{tm5(Erbb2)Mul}/Erbb2^tm1Haus
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Haus mutation (0 available); any Erbb2 mutation (59 available)
Erbb2^{tm5(Erbb2)Mul} mutation (0 available); any Erbb2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:94397 )

• mutants are normal, healthy, and fertile

Allelic Composition	Erbb2^{tm6(Erbb2)Mul}/Erbb2^tm1Haus
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Haus mutation (0 available); any Erbb2 mutation (59 available)
Erbb2^{tm6(Erbb2)Mul} mutation (0 available); any Erbb2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:94397 )

• die shortly after birth struggling unsuccessfully to breathe

respiratory system

respiratory failure ( J:94397 )

nervous system

abnormal phrenic nerve morphology ( J:94397 )

• phrenic nerves are thinned, disorganized, and discontinuous or incomplete and they lack an apparent main nerve trunk from which smaller presynaptic branches originate

defasiculated phrenic nerve ( J:94397 )

abnormal phrenic nerve innervation pattern to diaphragm ( J:94397 )

• diaphragm muscle is very poorly innervated by the phrenic nerve

cellular

defasiculated phrenic nerve ( J:94397 )

Allelic Composition	Erbb2^{tm7(Erbb2)Mul}/Erbb2^tm1Haus
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Haus mutation (0 available); any Erbb2 mutation (59 available)
Erbb2^{tm7(Erbb2)Mul} mutation (0 available); any Erbb2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:94397 )

• die shortly after birth struggling unsuccessfully to breathe

respiratory system

respiratory failure ( J:94397 )

nervous system

abnormal phrenic nerve morphology ( J:94397 )

• phrenic nerves are thinned, disorganized, and discontinuous or incomplete and they lack an apparent main nerve trunk from which smaller presynaptic branches originate

defasiculated phrenic nerve ( J:94397 )

abnormal phrenic nerve innervation pattern to diaphragm ( J:94397 )

• diaphragm muscle is very poorly innervated by the phrenic nerve

cellular

defasiculated phrenic nerve ( J:94397 )

Allelic Composition	Erbb2^{tm4(Erbb2)Mul}/Erbb2^tm1Haus
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Haus mutation (0 available); any Erbb2 mutation (59 available)
Erbb2^{tm4(Erbb2)Mul} mutation (0 available); any Erbb2 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:94397 )

• although the expected numbers of mutants were present at birth, they were either stillborn or started dying immediately after birth

respiratory system

respiratory failure ( J:94397 )

• cannot breathe despite the ability to open the mouth

• unable to inflate and expand lungs, despite the lungs being vascularized and structurally intact

homeostasis/metabolism

cyanosis ( J:94397 )

nervous system

abnormal sympathetic ganglion morphology ( J:94397 )

• only partial development of the thoracic sympathetic ganglia at E12.5, with defects becoming more severe in a rostral-caudal gradient

abnormal phrenic nerve morphology ( J:94397 )

• phrenic nerves are thinned, disorganized, and discontinuous or incomplete and they lack an apparent main nerve trunk from which smaller presynaptic branches originate

defasiculated phrenic nerve ( J:94397 )

abnormal phrenic nerve innervation pattern to diaphragm ( J:94397 )

• diaphragm muscle is very poorly innervated by the phrenic nerve

cellular

defasiculated phrenic nerve ( J:94397 )

Allelic Composition	Erbb2^tm1Haus/Erbb2^tm1Klee Gfra1^tm3Jmi/Gfra1⁺ Myf5^tm3(cre)Sor/Myf5⁺
Genetic Background	involves: 129S4/SvJae * 129S4/SvJaeSor * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Haus mutation (0 available); any Erbb2 mutation (59 available)
Erbb2^tm1Klee mutation (0 available); any Erbb2 mutation (59 available)
Gfra1^tm3Jmi mutation (0 available); any Gfra1 mutation (31 available)
Myf5^tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cholinergic neuron morphology ( J:160727 )

• the number of cholinergic motor neurons is decreased compared to in wild-type mice

decreased motor neuron number ( J:160727 )

• the number of cholinergic motor neurons is decreased compared to in wild-type mice

• mice exhibit a reduction in small Gfra1+ motor neurons compared with wild-type mice

• loss of gamma-motor neurons is intermediate to wild-type mice and Egr3^tm1Jmi homozygotes

• mice exhibit a decrease in large diameter motor neurons compared with wild-type mice

Allelic Composition	Erbb2^tm1Haus/Erbb2^tm1Klee Myf5^tm3(cre)Sor/Myf5⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb2^tm1Haus mutation (0 available); any Erbb2 mutation (59 available)
Erbb2^tm1Klee mutation (0 available); any Erbb2 mutation (59 available)
Myf5^tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

ataxia ( J:147957 )

abnormal posture ( J:147957 )

• mice show a flexed posture when inverted

abnormal gait ( J:147957 )

• mice exhibit a wide-based, ataxic gait

nervous system

abnormal muscle spindle morphology ( J:147957 )

• only rudimentary muscle spindles with a single Egr3-positive myofiber are seen in tibialis anterior muscles at P3 in contrast to spindles in controls which have multiple Egr3+ intrafusal myofibers

• on P4 muscle spindles, few mutant spindles have the complex annulospiral afferent terminal seen around the equatorial region of intrafusal myofibers in control muscle; muscle spindle afferent terminal morphology is simple compared to controls

• spindle development fails to progress beyond E18 and mature spindles do not form

decreased muscle spindle number ( J:147957 )

• in tibialis anterior (TA) muscle, muscle spindle numbers are decreased 70% from those of controls

abnormal sensory neuron innervation pattern ( J:147957 )

• innervation of muscle spindles is simpler than observed in controls, but spindle afferent projection to the ventral spinal cord shows normal pattern

abnormal excitatory postsynaptic potential ( J:147957 )

• monosynaptic inputs from muscle spindle afferent to motor neurons are functional but reduced in amplitude; EPSPs evoked by dorsal root stimulation or evoked by muscle nerve stimulation are reduced from those of controls by similar amounts (to about 22-26% of wild-type amplitudes)

muscle

abnormal muscle spindle morphology ( J:147957 )

• spindle development fails to progress beyond E18 and mature spindles do not form

decreased muscle spindle number ( J:147957 )

• in tibialis anterior (TA) muscle, muscle spindle numbers are decreased 70% from those of controls

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