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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Scarb1tm1Dhu
targeted mutation 1, Dennis Huszar
MGI:1928989
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Scarb1tm1Dhu/Scarb1tm1Dhu involves: 129S4/SvJae * BALB/cByJ MGI:2174743
cx2
Ldlrtm1Her/Ldlrtm1Her
Scarb1tm1Dhu/Scarb1tm1Dhu
involves: 129S4/SvJae * BALB/c * C57BL/6J MGI:3623224


Genotype
MGI:2174743
hm1
Allelic
Composition
Scarb1tm1Dhu/Scarb1tm1Dhu
Genetic
Background
involves: 129S4/SvJae * BALB/cByJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scarb1tm1Dhu mutation (0 available); any Scarb1 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• serum cholesterol levels are 50-70% higher than control values
• HDL levels are 51% greater than control values




Genotype
MGI:3623224
cx2
Allelic
Composition
Ldlrtm1Her/Ldlrtm1Her
Scarb1tm1Dhu/Scarb1tm1Dhu
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation (19 available); any Ldlr mutation (76 available)
Scarb1tm1Dhu mutation (0 available); any Scarb1 mutation (52 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• lesion size is significantly increased in males compared to LDL-receptor controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory