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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trim28tm1.1Ipc
targeted mutation 1.1, Pierre Chambon
MGI:1928907
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Trim28tm1.1Ipc/Trim28tm1.2Ipc
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S2/SvPas * C57BL/6 * CBA MGI:5620619
cn2
Trim28tm1.1Ipc/Trim28tm1.1Ipc
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129S2/SvPas * C57BL/6 * SJL MGI:4948089
cn3
Trim28tm1Fca/Trim28tm1.1Ipc
Plekha5Tg(AMH-cre)1Flor/Plekha5+
involves: 129S2/SvPas * C57BL/6 * SJL MGI:4948087


Genotype
MGI:5620619
cn1
Allelic
Composition
Trim28tm1.1Ipc/Trim28tm1.2Ipc
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (36 available)
Trim28tm1.1Ipc mutation (1 available); any Trim28 mutation (31 available)
Trim28tm1.2Ipc mutation (0 available); any Trim28 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• embryos no normal yolk sac protrusions or trophoblast malformations
• shorter and wider than in control mice

nervous system

digestive/alimentary system
• failure of gut closure

cardiovascular system




Genotype
MGI:4948089
cn2
Allelic
Composition
Trim28tm1.1Ipc/Trim28tm1.1Ipc
Plekha5Tg(AMH-cre)1Flor/Plekha5+
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plekha5Tg(AMH-cre)1Flor mutation (1 available); any Plekha5 mutation (87 available)
Trim28tm1.1Ipc mutation (1 available); any Trim28 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• decrease in the number of mature spermatids
• spermatids fail to align at the luminal side of the seminiferous tubules at stage VII of the epithelial cycle
• germ cell depletion
• the caudal epididymis contains few spermatozoa

reproductive system
N
• no defects are detected in Sertoli cell or spermatogonia proliferation at P5
• decrease in the number of mature spermatids
• spermatids fail to align at the luminal side of the seminiferous tubules at stage VII of the epithelial cycle
• germ cell depletion
• the caudal epididymis contains few spermatozoa
• at 7 weeks and 12 months of age
• testicular degeneration
• mature spermatids are retained within the seminiferous epithelium
• sire smaller litters when crossed to wild-type females
• sire fewer and smaller litters when crossed to wild-type females

endocrine/exocrine glands
• at 7 weeks and 12 months of age
• testicular degeneration




Genotype
MGI:4948087
cn3
Allelic
Composition
Trim28tm1Fca/Trim28tm1.1Ipc
Plekha5Tg(AMH-cre)1Flor/Plekha5+
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plekha5Tg(AMH-cre)1Flor mutation (1 available); any Plekha5 mutation (87 available)
Trim28tm1.1Ipc mutation (1 available); any Trim28 mutation (31 available)
Trim28tm1Fca mutation (0 available); any Trim28 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• testes morphology is indistinguishable from controls at 7 weeks of age





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory