All Phenotypes Hoxb1<tm5Mrc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hoxb1^tm5Mrc
targeted mutation 5, Mario R Capecchi
MGI:1928090

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxb1^tm5Mrc/Hoxb1^tm5Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2175215
hm2	Hoxb1^tm5Mrc/Hoxb1^tm5Mrc	Not Specified	MGI:3038606
ht3	Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703020
ht4	Hoxb1^tm5Mrc/Hoxb1^tm9Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3703047
cn5	Hoxb1^tm5Mrc/Hoxb1^tm7Mrc Tfap2a^tm1(cre)Moon/Tfap2a⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:3050415
cn6	Hoxb1^tm5Mrc/Hoxb1^tm7Mrc H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	Not Specified	MGI:3050407
cx7	Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc} Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703012
cx8	Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc} Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6	MGI:3703016
cx9	Hoxa1^tm5Mrc/Hoxa1^tm5Mrc Hoxb1^tm5Mrc/Hoxb1^tm5Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3703022
cx10	Hoxa1^tm5Mrc/Hoxa1⁺ Hoxb1^tm5Mrc/Hoxb1^tm5Mrc	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3703018

Allelic Composition	Hoxb1^tm5Mrc/Hoxb1^tm5Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb1^tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent facial nuclei ( J:119279 )

• facial nucleus is absent in brainstem

absent facial nerve ( J:119279 )

• facial nerve is absent in brainstem

Allelic Composition	Hoxb1^tm5Mrc/Hoxb1^tm5Mrc
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb1^tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased sensory neuron number ( J:88581 )

• absence of noradrenergic visceral sensory interneurons and associated expansion of the somatic sensory interneuron domain in rhombomere 4

Allelic Composition	Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb1^tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)
Hoxb1^{tm8(Hoxa1)Mrc} mutation (0 available); any Hoxb1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:119279 )

• mutants are indistinguishable from wild-type

Allelic Composition	Hoxb1^tm5Mrc/Hoxb1^tm9Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb1^tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)
Hoxb1^tm9Mrc mutation (0 available); any Hoxb1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal reflex ( J:119279 )

• 20% of mutants show a mild form of incomplete eyelid closure in response to stimulus

Allelic Composition	Hoxb1^tm5Mrc/Hoxb1^tm7Mrc Tfap2a^tm1(cre)Moon/Tfap2a⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb1^tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)
Hoxb1^tm7Mrc mutation (0 available); any Hoxb1 mutation (24 available)
Tfap2a^tm1(cre)Moon mutation (1 available); any Tfap2a mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:91364 )

N	• no behavioral abnormalities are seen

nervous system

decreased motor neuron number ( J:91364 )

• the average number of motor neurons is significantly reduced in mutants compared to wild-type mice although not to the same extent as in compound heterozygous mutants carrying Tg(Wnt1-cre)11Rth

Allelic Composition	Hoxb1^tm5Mrc/Hoxb1^tm7Mrc H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Hoxb1^tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)
Hoxb1^tm7Mrc mutation (0 available); any Hoxb1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal reflex ( J:91364 )

• some mutants are unable to move their ears

abnormal blinking ( J:91364 )

• some mutants are unable to blink their eyes

abnormal vibrissae reflex ( J:91364 )

• some mutants are unable to move their whiskers

paralysis ( J:91364 )

• 35% of mutants show total facial paralysis and another 10% show partial facial paralysis

nervous system

decreased motor neuron number ( J:91364 )

• increased motor neuron loss is seen from E14.5 to E16.5 when motor neuron pruning normally occurs resulting a significant decrease in the average number of motor neurons in mutants compared to wild-type mice

abnormal facial nerve morphology ( J:91364 )

• loss of VII th cranial nerve branches is seen

• at E12.5 the average number of axonal branch points is decreased

Allelic Composition	Hoxa1^tm3.1Mrc/Hoxa1^{tm4(Hoxb1)Mrc} Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1^tm3.1Mrc mutation (0 available); any Hoxa1 mutation (14 available)
Hoxa1^{tm4(Hoxb1)Mrc} mutation (0 available); any Hoxa1 mutation (14 available)
Hoxb1^tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)
Hoxb1^{tm8(Hoxa1)Mrc} mutation (0 available); any Hoxb1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal blinking ( J:119279 )

• facial paralysis is predominantly manifested in impaired eyeblink reflex

facial paralysis ( J:119279 )

• majority of mice show various levels of facial paralysis

Allelic Composition	Hoxa1^{tm4(Hoxb1)Mrc}/Hoxa1^{tm4(Hoxb1)Mrc} Hoxb1^tm5Mrc/Hoxb1^{tm8(Hoxa1)Mrc}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1^{tm4(Hoxb1)Mrc} mutation (0 available); any Hoxa1 mutation (14 available)
Hoxb1^tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)
Hoxb1^{tm8(Hoxa1)Mrc} mutation (0 available); any Hoxb1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal reflex ( J:119279 )

• eyeblink reflex is impaired in 58% of mutants; only 11% are considered to be severely affected

nervous system

abnormal facial nerve morphology ( J:119279 )

• zygomatic and temporal branches of facial nerve have normal caliber, but occasionally show atypical arborization pattern

Allelic Composition	Hoxa1^tm5Mrc/Hoxa1^tm5Mrc Hoxb1^tm5Mrc/Hoxb1^tm5Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxa1^tm5Mrc mutation (0 available); any Hoxa1 mutation (14 available)
Hoxb1^tm5Mrc mutation (0 available); any Hoxb1 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:119279 )

N	• facial motor nuclei are not markedly different from wild-type

Allelic Composition	Hoxa1^tm5Mrc/Hoxa1⁺ Hoxb1^tm5Mrc/Hoxb1^tm5Mrc
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal reflex ( J:119279 )

• 17% of mice have a noticeably narrower range of whisker movements on one side

• 8% have a mutant-like eyelid closure reflex in one eye

paralysis ( J:119279 )

• some facial motor hypomorphism is observed; Hoxa1 haploinsufficiency is observed

nervous system

small facial motor nucleus ( J:119279 )

• haploinsufficient presumptive facial nuclei are smaller, rounder, and located more internally than wild-type

abnormal facial nerve morphology ( J:119279 )

• zygomatic and temporal branches of facial nerve in affected mutants are thinner and sometimes atypically formed, but rarely missing

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