Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spi1tm1Ram mutation
(0 available);
any
Spi1 mutation
(27 available)
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vision/eye
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• the pupillary membrane and tunica vasculosa lentis persist postnatally unlike in wild-type mice due to a defective clearance of apoptotic cells
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hematopoietic system
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• mice lack ocular macrophages
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homeostasis/metabolism
immune system
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• mice lack ocular macrophages
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spi1tm1Ram mutation
(0 available);
any
Spi1 mutation
(27 available)
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mortality/aging
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• antibiotic-treated mice receiving bone marrow transplants have a life expectancy of 331 +/- 20 days
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• all mice develop septicemia and die within 24 hours of birth, but mice treated with antibiotics live up to 17 days of age
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immune system
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• no mature neutrophils are found in the blood, liver, spleen or bone marrow and fewer immature neutrophils are identified
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• no mature macrophages are detected
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• T cell development is delayed with T cells appearing 3 to 5 days after birth in antibiotic treated mice
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• in the thymus and periphery
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• no mature neutrophils are found in the blood, liver, spleen or bone marrow and fewer immature neutrophils are identified
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• in the thymus and periphery
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• in the thymus and periphery
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• in the thymus and periphery
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• no mature macrophages are detected
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• microglia exhibit more prominent, rounded cell bodies and shorter or thicker processes indicating a less differentiated state
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• all mice develop septicemia and die within 24 hours of birth
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liver/biliary system
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• occasionally mice exhibit a slightly darker red liver than wild-type mice
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nervous system
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• microglia exhibit more prominent, rounded cell bodies and shorter or thicker processes indicating a less differentiated state
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• bone marrow donor cells fail to develop into astrocytes
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growth/size/body
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• antibiotic-treated mice receiving bone marrow cells from Tg(SOD1*G93A)1Gur mice growing slower than those receiving wild-type bone marrow cells
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hematopoietic system
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• no mature neutrophils are found in the blood, liver, spleen or bone marrow and fewer immature neutrophils are identified
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• no mature macrophages are detected
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• T cell development is delayed with T cells appearing 3 to 5 days after birth in antibiotic treated mice
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• no mature neutrophils are found in the blood, liver, spleen or bone marrow and fewer immature neutrophils are identified
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• in the thymus and periphery
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• in the thymus and periphery
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• in the thymus and periphery
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• in the thymus and periphery
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• no mature macrophages are detected
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• microglia exhibit more prominent, rounded cell bodies and shorter or thicker processes indicating a less differentiated state
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cellular
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• no mature neutrophils are found in the blood, liver, spleen or bone marrow and fewer immature neutrophils are identified
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• no mature macrophages are detected
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endocrine/exocrine glands
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• in the thymus and periphery
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Allelic Composition |
Spi1tm1Ram/Spi1+
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Genetic Background |
involves: 129S2/SvPas |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spi1tm1Ram mutation
(0 available);
any
Spi1 mutation
(27 available)
|
|
|
vision/eye
|
• the pupillary membrane and tunica vasculosa lentis partially persist postnatally unlike in wild-type mice due to a defective clearance of apoptotic cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spi1tm1Ram mutation
(0 available);
any
Spi1 mutation
(27 available)
Tg(SOD1*G93A)1Gur mutation
(4 available)
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mortality/aging
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• mice receiving bone marrow from when treated with wild-type bone marrow transfer survive longer than Tg(SOD1*G93A)1Gur mice or mice receiving bone marrow transfers Tg(SOD1*G93A)1Gur mice but not as long as wild-type mice
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nervous system
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• motor neuron loss is more severe in mice receiving bone marrow transfer from Tg(SOD1*G93A)1Gur mice compared to mice receiving bone marrow transfers from wild-type mice that do not exhibit a significant amount of neuron loss
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• antibiotic-treated mice receiving bone marrow cells from wild-type donors exhibit reduced motor neuron disease progression compared to those receiving bone marrow transplants from Tg(SOD1*G93A)1Gur mice
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growth/size/body
N |
• antibiotic-treated mice exhibit normal growth rates
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