All Phenotypes Cd74<tm1Doi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd74^tm1Doi
targeted mutation 1, Christophe Benoist and Diane Mathis
MGI:1927205

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd74^tm1Doi/Cd74^tm1Doi	either: (involves: 129/Sv * B10.BR) or (involves: 129/Sv * C57BL/6)	MGI:2386165
hm2	Cd74^tm1Doi/Cd74^tm1Doi	involves: 129S2/SvPas	MGI:4355887
cx3	H2-DMa^tm1Luc/H2-DMa^tm1Luc Cd74^tm1Doi/Cd74^tm1Doi	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6	MGI:2665538
cx4	Cd74^tm1Doi/Cd74^tm1Doi H2-DMa^tm1Doi/H2-DMa^tm1Doi	involves: 129S2/SvPas * C57BL/6	MGI:2386166
cx5	Cd74^tm1Doi/Cd74^tm1Doi Tap1^tm1Arp/Tap1^tm1Arp	involves: 129S2/SvPas * C57BL/6	MGI:3814823
cx6	Cd1d1^tm1.1Boes/Cd1d1^tm1.1Boes Cd74^tm1Doi/Cd74^tm1Doi	involves: 129S2/SvPas * C57BL/6	MGI:4355888

Allelic Composition	Cd74^tm1Doi/Cd74^tm1Doi
Genetic Background	either: (involves: 129/Sv * B10.BR) or (involves: 129/Sv * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:4119 , J:45185 )

• reduction in the CD4+CD8- cell population in the thymus and periphery (J:4119)

• reduced number of peripheral CD4+ T cells (J:45185)

increased CD8-positive, alpha-beta T cell number ( J:4119 )

• increase in CD4-CD8+ cell population in the thymus and periphery

abnormal antigen presentation ( J:4119 )

• antigen presenting cells (APCs) had defective proteine and peptide presentation

abnormal level of surface class II molecules ( J:45185 )

• abnormal level of surface class II molecules on B cells

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:4119 , J:45185 )

• reduction in the CD4+CD8- cell population in the thymus and periphery (J:4119)

• reduced number of peripheral CD4+ T cells (J:45185)

increased CD8-positive, alpha-beta T cell number ( J:4119 )

• increase in CD4-CD8+ cell population in the thymus and periphery

Allelic Composition	Cd74^tm1Doi/Cd74^tm1Doi
Genetic Background	involves: 129S2/SvPas

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell antigen presentation ( J:151699 )

• dendritic cells loaded with alphaGal-Cer are defective in activating wild-type Valpha14 invariant NKT cells

Allelic Composition	H2-DMa^tm1Luc/H2-DMa^tm1Luc Cd74^tm1Doi/Cd74^tm1Doi
Genetic Background	involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (33 available)
H2-DMa^tm1Luc mutation (1 available); any H2-DMa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal level of surface class II molecules ( J:45185 )

• reduced level of surface class II molecules on B cells

increased susceptibility to parasitic infection ( J:45185 )

• increased susceptibility to Leishmania major infection

Allelic Composition	Cd74^tm1Doi/Cd74^tm1Doi H2-DMa^tm1Doi/H2-DMa^tm1Doi
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (33 available)
H2-DMa^tm1Doi mutation (1 available); any H2-DMa mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:42482 )

• significant mortality after a few weeks of age

growth/size/body

decreased body size ( J:42482 )

• showed runting

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:42482 )

• reduction in the CD4+CD8- cell population and a compensatory increase in CD4-CD8+ cell population

increased CD8-positive, alpha-beta T cell number ( J:42482 )

• compensatory increase in CD4-CD8+ cell population due to reduction in the CD4+CD8- cell population

immune system

decreased CD4-positive, alpha-beta T cell number ( J:42482 )

• reduction in the CD4+CD8- cell population and a compensatory increase in CD4-CD8+ cell population

increased CD8-positive, alpha-beta T cell number ( J:42482 )

• compensatory increase in CD4-CD8+ cell population due to reduction in the CD4+CD8- cell population

abnormal professional antigen presenting cell physiology ( J:42482 )

• antigen presenting cells (APCs) had defective protein and peptide presentation

Allelic Composition	Cd74^tm1Doi/Cd74^tm1Doi Tap1^tm1Arp/Tap1^tm1Arp
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (33 available)
Tap1^tm1Arp mutation (4 available); any Tap1 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell number ( J:113083 )

• numbers of typical (i.e. CD4⁺- or CD8⁺- T cells) are reduced

• T cells that express the canonical mVa19-Ja33 TCR rearrangement are 10-fold more abundant in the lamina propia of the gut compared to controls

immune system

abnormal T cell number ( J:113083 )

• numbers of typical (i.e. CD4⁺- or CD8⁺- T cells) are reduced

• T cells that express the canonical mVa19-Ja33 TCR rearrangement are 10-fold more abundant in the lamina propia of the gut compared to controls

Allelic Composition	Cd1d1^tm1.1Boes/Cd1d1^tm1.1Boes Cd74^tm1Doi/Cd74^tm1Doi
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1^tm1.1Boes mutation (0 available); any Cd1d1 mutation (30 available)
Cd74^tm1Doi mutation (1 available); any Cd74 mutation (33 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell antigen presentation ( J:151699 )

• dendritic cells loaded with alphaGal-Cer are defective in activating wild-type Valpha14 invariant NKT cells

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