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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Atmtm1Led
targeted mutation 1, Philip Leder
MGI:1926875
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Atmtm1Led/Atmtm1Led involves: 129S6/SvEvTac * Black Swiss MGI:2175708
cx2
Atmtm1Led/Atm+
Kat8tm2Thl/Kat8+
involves: 129S1/Sv * 129S6/SvEvTac MGI:3769385
cx3
Atmtm1Led/Atmtm1Led
Kat8tm2Thl/Kat8+
involves: 129S1/Sv * 129S6/SvEvTac MGI:3769386


Genotype
MGI:2175708
hm1
Allelic
Composition
Atmtm1Led/Atmtm1Led
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Led mutation (0 available); any Atm mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Cross section through seminiferous tubule of +/+ and Atmtm1Led/Atmtm1Led mice

mortality/aging
• 100% mortality by 40 weeks of age (J:69726)
• 100% mortality by 40 weeks of age (J:69726)

growth/size/body

immune system
• fourfold decrease in CD4+CD8- single positive cells (J:36561)
• fourfold decrease in CD4+CD8- single positive cells (J:36561)

reproductive system
• testes were structurally abnormal (J:36561)
• testes were structurally abnormal (J:36561)
(J:36561)
(J:36561)
• lack of maturing sperm within the seminiferous tubules and of mature sperm in the tubule lumen, the epididymis, and ductus deferens (J:36561)
• lack of maturing sperm within the seminiferous tubules and of mature sperm in the tubule lumen, the epididymis, and ductus deferens (J:36561)
(J:36561)
(J:36561)

tumorigenesis
• some develop malignant thymomas between 3 and 4 months of age (J:36561)
• some develop malignant thymomas between 3 and 4 months of age (J:36561)
• mostly of double positive T cells (J:69726)
• mostly of double positive T cells (J:69726)

cellular
• 3 fold increase in radiation induced chromosomal aberrations (J:69726)
• 3 fold increase in radiation induced chromosomal aberrations (J:69726)
• increased sensitivity of thymocytes and splenocytes to ionizing radiation (J:69726)
• increased sensitivity of thymocytes and splenocytes to ionizing radiation (J:69726)
• fibroblasts exhibited nearly 6.5-fold more chromosomal breaks per metaphase than controls (J:36561)
• fibroblasts exhibited nearly 6.5-fold more chromosomal breaks per metaphase than controls (J:36561)

nervous system
• survival of Purkinje cells in culture less than 60% of controls at 4 days and about 40% at 10 days (J:86894)
• survival of cultured cells improves if cultured with cerebellar astroglial cell (J:86894)
• develop simpler dendritic arboritization with reduced secondary branching (J:86894)
• nitroxide free radicals improve survival and arborization (J:86894)
• survival of Purkinje cells in culture less than 60% of controls at 4 days and about 40% at 10 days (J:86894)
• survival of cultured cells improves if cultured with cerebellar astroglial cell (J:86894)
• develop simpler dendritic arboritization with reduced secondary branching (J:86894)
• nitroxide free radicals improve survival and arborization (J:86894)

endocrine/exocrine glands
• testes were structurally abnormal (J:36561)
• testes were structurally abnormal (J:36561)
(J:36561)
(J:36561)

hematopoietic system
• fourfold decrease in CD4+CD8- single positive cells (J:36561)
• fourfold decrease in CD4+CD8- single positive cells (J:36561)

Mouse Models of Human Disease
OMIM ID Ref(s)
Ataxia-Telangiectasia; AT 208900 J:36561




Genotype
MGI:3769385
cx2
Allelic
Composition
Atmtm1Led/Atm+
Kat8tm2Thl/Kat8+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Led mutation (0 available); any Atm mutation (30 available)
Kat8tm2Thl mutation (0 available); any Kat8 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 76% of mice survive the first year (J:128936)
• only 76% of mice survive the first year (J:128936)




Genotype
MGI:3769386
cx3
Allelic
Composition
Atmtm1Led/Atmtm1Led
Kat8tm2Thl/Kat8+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmtm1Led mutation (0 available); any Atm mutation (30 available)
Kat8tm2Thl mutation (0 available); any Kat8 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die earlier than Atmtm1Led homozygotes (J:128936)
• mice die earlier than Atmtm1Led homozygotes (J:128936)

growth/size/body
• mice exhibit a modest reduction in weight compared to Atmtm1Led homozygotes (J:128936)
• mice exhibit a modest reduction in weight compared to Atmtm1Led homozygotes (J:128936)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory