mortality/aging
|
• 100% mortality by 40 weeks of age
|
growth/size
immune system
|
• fourfold decrease in CD4+CD8- single positive cells
|
small thymus
(
J:36561
)
reproductive system
 |
• testes were structurally abnormal
(J:36561)
|
small testis
(
J:36561
)
|
|
(J:36561)
|
azoospermia
(
J:36561
)
|
|
• lack of maturing sperm within the seminiferous tubules and of mature sperm in the tubule lumen, the epididymis, and ductus deferens
(J:36561)
|
|
|
(J:36561)
|
tumorigenesis
|
• some develop malignant thymomas between 3 and 4 months of age
(J:36561)
• mostly of double positive T cells
(J:69726)
|
cellular
|
• 3 fold increase in radiation induced chromosomal aberrations
|
|
• increased sensitivity of thymocytes and splenocytes to ionizing radiation
|
|
• fibroblasts exhibited nearly 6.5-fold more chromosomal breaks per metaphase than controls
|
nervous system
|
• survival of Purkinje cells in culture less than 60% of controls at 4 days and about 40% at 10 days
• survival of cultured cells improves if cultured with cerebellar astroglial cell
• develop simpler dendritic arboritization with reduced secondary branching
• nitroxide free radicals improve survival and arborization
|
endocrine/exocrine glands
|
|
• testes were structurally abnormal
(J:36561)
|
small testis
(
J:36561
)
|
|
(J:36561)
|
hematopoietic system
|
• fourfold decrease in CD4+CD8- single positive cells
|
small thymus
(
J:36561
)
Mouse Models of Human Disease |
OMIM ID | Ref(s) | |
| Ataxia-Telangiectasia; AT | 208900 | J:36561 | |