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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(PTHLH)7Wmp
transgene insertion 7, William M Philbrick
MGI:1926698
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Pthlhtm1Hmk/Pthlhtm1Hmk
Tg(Col2a1-PTHLH)2Ecw/0
Tg(PTHLH)7Wmp/0
involves: 129S2/SvPas * C57BL/6 * SJL MGI:3717420
tg2
Tg(PTHLH)7Wmp/0 Not Specified MGI:2174880


Genotype
MGI:3717420
cx1
Allelic
Composition
Pthlhtm1Hmk/Pthlhtm1Hmk
Tg(Col2a1-PTHLH)2Ecw/0
Tg(PTHLH)7Wmp/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pthlhtm1Hmk mutation (0 available); any Pthlh mutation (11 available)
Tg(Col2a1-PTHLH)2Ecw mutation (0 available)
Tg(PTHLH)7Wmp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Dental phenotype of Pthlhtm1Hmk/Pthlhtm1Hmk mice rescued with Tg(Col2a1-PTHLH)2Ecw and Tg(PTHLH)7Wmp transgenes

mortality/aging

growth/size/body
• malocclusion allows for unchecked growth of the lower incisors

skeleton
• foreshortened maxilla
• malocclusion allows for unchecked growth of the lower incisors
• as a result of the chondrodystrophy in the skulls, the lower mandibular incisors protrude beyond the upper incisors
• upper incisors remain partly occluded and are less affected
• however, incisors and molars erupt normally and on schedule
• develop progressive chondrodystrophy

craniofacial
• foreshortened maxilla
• malocclusion allows for unchecked growth of the lower incisors
• as a result of the chondrodystrophy in the skulls, the lower mandibular incisors protrude beyond the upper incisors
• upper incisors remain partly occluded and are less affected
• however, incisors and molars erupt normally and on schedule




Genotype
MGI:2174880
tg2
Allelic
Composition
Tg(PTHLH)7Wmp/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• very little fat is present in the subcutis

integument
• very little fat is present in the subcutis
• the relative frequency of the auchene hairs is reduced
• the relative frequency of the awl hairs is reduced
• by 6 days of age, mutants exhibit ventral hairlessness that extends the length of the body and to the midaxillary lines bilaterally
• males are less severely affected and show some ventral hair growth in two paramedial strips
• all hair types are present but are shorter
• dorsal coat is thinner and is deficient in overhairs, the long hairs that protrude beyond the general coat
• all hair types are present but are thinner
• hair follicles are almost completely absent in the ventral skin
• fail to initiate follicle development in the ventral skin, leading to absence of hair follicles
• show a delay in the initiation of hair follicles and eruption of hair on the dorsal skin
• a somewhat lower density of hair follicles occurs dorsally, with a selective decrease in the larger and more deeply penetrating follicles
• tail skin shows an effacement of the alternating ridge-like epidermal pattern
• the ventral dermis is expanded
• mild hyperkeratosis in the ventral epidermis and ear epidermis
• the ventral epidermis and the epidermis of the ear are thickened
• overall thickness of the skin is reduced due to the decreased amount of fat in the subcutis





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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory