Mouse Genome Informatics
cx1
    Pthlhtm1Hmk/Pthlhtm1Hmk
Tg(Col2a1-PTHLH)2Ecw/0
Tg(PTHLH)7Wmp/0

involves: 129S2/SvPas * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype

Dental phenotype of Pthlhtm1Hmk/Pthlhtm1Hmk mice rescued with Tg(Col2a1-PTHLH)2Ecw and Tg(PTHLH)7Wmp transgenes

mortality/aging

growth/size
• malocclusion allows for unchecked growth of the lower incisors

skeleton
• foreshortened maxilla
• as a result of the chondrodystrophy in the skulls, the lower mandibular incisors protrude beyond the upper incisors
• upper incisors remain partly occluded and are less affected
• however, incisors and molars erupt normally and on schedule
• develop progressive chondrodystrophy

craniofacial
• foreshortened maxilla
• as a result of the chondrodystrophy in the skulls, the lower mandibular incisors protrude beyond the upper incisors
• upper incisors remain partly occluded and are less affected
• however, incisors and molars erupt normally and on schedule
• malocclusion allows for unchecked growth of the lower incisors


Mouse Genome Informatics
tg2
    Tg(PTHLH)7Wmp/0
Not Specified
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
adipose tissue
• very little fat is present in the subcutis

integument
• very little fat is present in the subcutis
• the relative frequency of the auchene hairs is reduced
• the relative frequency of the awl hairs is reduced
• by 6 days of age, mutants exhibit ventral hairlessness that extends the length of the body and to the midaxillary lines bilaterally
• males are less severely affected and show some ventral hair growth in two paramedial strips
• all hair types are present but are shorter
• dorsal coat is thinner and is deficient in overhairs, the long hairs that protrude beyond the general coat
• all hair types are present but are thinner
• hair follicles are almost completely absent in the ventral skin
• fail to initiate follicle development in the ventral skin, leading to absence of hair follicles
• show a delay in the initiation of hair follicles and eruption of hair on the dorsal skin
• a somewhat lower density of hair follicles occurs dorsally, with a selective decrease in the larger and more deeply penetrating follicles
• tail skin shows an effacement of the alternating ridge-like epidermal pattern
• the ventral dermis is expanded
• mild hyperkeratosis in the ventral epidermis and ear epidermis
• the ventral epidermis and the epidermis of the ear are thickened
• overall thickness of the skin is reduced due to the decreased amount of fat in the subcutis