Mouse Genome Informatics
hm1
    Gfra2tm1Msa/Gfra2tm1Msa
either: (involves: 129S1/Sv * 129S2/SvHsd * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6NHsd)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
behavior/neurological
• suppressed development and persistence of kindling epilepsy

growth/size

nervous system
• suppressed development and persistence of kindling epilepsy
• absent projections to the lacrimal gland, parotid gland and the sublingual gland

vision/eye

integument


Mouse Genome Informatics
hm2
    Gfra2tm1Msa/Gfra2tm1Msa
either: B6.129-Gfra2tm1Msa or 129S2.129-Gfra2tm1Msa
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
adipose tissue
• weight reduced by 40%

behavior/neurological
• increased water intake
• slight but significant increase in food intake

digestive/alimentary system
• motility of the small intestine is reduced

homeostasis/metabolism
• basal metabolic rate was increased


Mouse Genome Informatics
hm3
    Gfra2tm1Msa/Gfra2tm1Msa
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
integument
• exhibit accelerated catagen development, such that at P17, most hair follicles are already in late catagen rather than at the beginning of catagen
• seen at P17