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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gfra2tm1Msa
targeted mutation 1, Matti S Airaksinen
MGI:1926440
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gfra2tm1Msa/Gfra2tm1Msa either: (involves: 129S1/Sv * 129S2/SvHsd * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6NHsd) MGI:3582982
hm2
Gfra2tm1Msa/Gfra2tm1Msa either: B6.129-Gfra2tm1Msa or 129S2.129-Gfra2tm1Msa MGI:3582983
hm3
Gfra2tm1Msa/Gfra2tm1Msa involves: 129S1/Sv * 129X1/SvJ MGI:3654033


Genotype
MGI:3582982
hm1
Allelic
Composition
Gfra2tm1Msa/Gfra2tm1Msa
Genetic
Background
either: (involves: 129S1/Sv * 129S2/SvHsd * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6NHsd)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra2tm1Msa mutation (0 available); any Gfra2 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• suppressed development and persistence of kindling epilepsy

growth/size/body

nervous system
• suppressed development and persistence of kindling epilepsy
• absent projections to the lacrimal gland, parotid gland and the sublingual gland

vision/eye

integument




Genotype
MGI:3582983
hm2
Allelic
Composition
Gfra2tm1Msa/Gfra2tm1Msa
Genetic
Background
either: B6.129-Gfra2tm1Msa or 129S2.129-Gfra2tm1Msa
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra2tm1Msa mutation (0 available); any Gfra2 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• weight reduced by 40%

behavior/neurological
• increased water intake
• slight but significant increase in food intake

digestive/alimentary system
• motility of the small intestine is reduced

homeostasis/metabolism
• basal metabolic rate was increased




Genotype
MGI:3654033
hm3
Allelic
Composition
Gfra2tm1Msa/Gfra2tm1Msa
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra2tm1Msa mutation (0 available); any Gfra2 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• exhibit accelerated catagen development, such that at P17, most hair follicles are already in late catagen rather than at the beginning of catagen
• seen at P17





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory