Mouse Genome Informatics
hm1
     Gfra2tm1Msa/Gfra2tm1Msa
either: (involves: 129S1/Sv * 129S2/SvHsd * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6NHsd)
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
behavior/neurological
reduced kindling response ( J:53284 )
• suppressed development and persistence of kindling epilepsy

growth/size

nervous system
reduced kindling response ( J:53284 )
• suppressed development and persistence of kindling epilepsy
abnormal parasympathetic postganglionic fiber morphology ( J:53284 )
• absent projections to the lacrimal gland, parotid gland and the sublingual gland

vision/eye

integument


Mouse Genome Informatics
hm2
     Gfra2tm1Msa/Gfra2tm1Msa
either: B6.129-Gfra2tm1Msa or 129S2.129-Gfra2tm1Msa
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
adipose tissue
decreased gonadal fat pad weight ( J:93911 )
• weight reduced by 40%

behavior/neurological
increased fluid intake ( J:93911 )
• increased water intake
increased food intake ( J:93911 )
• slight but significant increase in food intake

digestive/alimentary system
intestinal hypoperistalsis ( J:93911 )
• motility of the small intestine is reduced

homeostasis/metabolism
increased basal metabolism ( J:93911 )
• basal metabolic rate was increased


Mouse Genome Informatics
hm3
     Gfra2tm1Msa/Gfra2tm1Msa
involves: 129S1/Sv * 129X1/SvJ
Key:
♀ phenotype observed in females WTSI Wellcome Trust Sanger Institute
♂ phenotype observed in males Euro Europhenome
N normal phenotype
integument
accelerated hair follicle regression ( J:65034 )
• exhibit accelerated catagen development, such that at P17, most hair follicles are already in late catagen rather than at the beginning of catagen
thin skin ( J:65034 )
• seen at P17