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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tcf7l2tm1Cle
targeted mutation 1, Hans Clevers
MGI:1926344
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tcf7l2tm1Cle/Tcf7l2tm1Cle involves: 129P2/OlaHsd MGI:3032499
cn2
Tcf3tm1.1Efu/Tcf3tm1.1Efu
Tcf7l2tm1Cle/Tcf7l2tm1Cle
Tg(KRT14-cre)1Efu/0
involves: 129/Sv * 129P2/OlaHsd MGI:4413471


Genotype
MGI:3032499
hm1
Allelic
Composition
Tcf7l2tm1Cle/Tcf7l2tm1Cle
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf7l2tm1Cle mutation (0 available); any Tcf7l2 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• pups die within 24 hours of birth

digestive/alimentary system
• at E16.5 there are no cycling cells detected in intestinal epithelium
• cells of intervillus region do not have characteristics of intervillus prospective crypt cells, instead displaying characteristics including closely packed long microvilli, round nuclei, supranuclear Golgi, many rod-shaped mitochondria, and absence of mitotic figures
• enterocytes on villi are decreased in number and broader in homozygotes than in wild-type

endocrine/exocrine glands
• anterior pituitary lobes are enlarged to nearly twice the normal height by E14.5
• a 3-fold increase in combined volume of anterior and intermediate lobes is observed compared to wild-type mice
• prospective intermediate lobe and infundibulum are displaced dorsally; these protrude into space normally occupied by hypothalamus

craniofacial
• pituitary gland is expanded ventrally between edges of cartilage plate in the midline during palate development

cellular
N
• no differences in cell proliferation in tissue of small intestine is observed at E14.5

nervous system
• anterior pituitary lobes are enlarged to nearly twice the normal height by E14.5
• a 3-fold increase in combined volume of anterior and intermediate lobes is observed compared to wild-type mice
• prospective intermediate lobe and infundibulum are displaced dorsally; these protrude into space normally occupied by hypothalamus




Genotype
MGI:4413471
cn2
Allelic
Composition
Tcf3tm1.1Efu/Tcf3tm1.1Efu
Tcf7l2tm1Cle/Tcf7l2tm1Cle
Tg(KRT14-cre)1Efu/0
Genetic
Background
involves: 129/Sv * 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1.1Efu mutation (0 available); any Tcf3 mutation (27 available)
Tcf7l2tm1Cle mutation (0 available); any Tcf7l2 mutation (31 available)
Tg(KRT14-cre)1Efu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• hair follicles appear but exhibit defects in subsequent down-growth compared to in wild-type mice
• in skin grafts
• newborn mice often lack whiskers unlike wild-type mice
• basal cells are flattened unlike in wild-type mice
• in newborn mice
• at P0, skin cells exhibit increased cell death compared to in wild-type mice
• grafted skin exhibits no hair and shrunk area without inflammation compared with wild-type skin grafts
• cultured skin epithelial fails to undergo long-term tissue maintenance unlike wild-type skin
• cultured keratinocytes from P0 mice exhibit decreased proliferation compared with wild-type cells

cellular
• cultured keratinocytes from P0 mice exhibit decreased proliferation compared with wild-type cells





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last database update
09/19/2017
MGI 6.10
The Jackson Laboratory