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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Chrna4tm1Jpc
targeted mutation 1, Jean-Pierre Changeux
MGI:1926251
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Chrna4tm1Jpc/Chrna4tm1Jpc B6.Cg-Chrna4tm1Jpc MGI:5318691
hm2
Chrna4tm1Jpc/Chrna4tm1Jpc involves: C57BL/6 MGI:3843520


Genotype
MGI:5318691
hm1
Allelic
Composition
Chrna4tm1Jpc/Chrna4tm1Jpc
Genetic
Background
B6.Cg-Chrna4tm1Jpc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna4tm1Jpc mutation (0 available); any Chrna4 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• distribution of retinogeniculate projections to the lateral geniculate nucleus and to the superior colliculus are not affected




Genotype
MGI:3843520
hm2
Allelic
Composition
Chrna4tm1Jpc/Chrna4tm1Jpc
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chrna4tm1Jpc mutation (0 available); any Chrna4 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• nicotine and epibatidine binding sites are absent in most brain regions of mutant mice; reduced levels of nicotine binding are seen in the interpendicular nucleus (IP) while high levels of epibatidine persisted in the medial habenula (MH), superior colliculus (SC) and at low levels in the substantia nigra (SN)
• patch-clamp recordings indicate a loss of nicotine -elicited currents in serotonergic neurons in the raphe nucleus and thalamic neurons from mutant mice
• however, neurons in the superficial layers of the dorsal horn of the spinal cord continue to show a nicotine-elicited, dose-dependent augmentation of the frequency of post-synaptic currents

behavior/neurological
• latency response to painful stimuli in the hot plate test and tail flick test does not differ significantly between mutant and control mice
• mutant mice do not show an antinociceptive response to the hot plate test at any dose of nicotine, whereas control mice show a dose-dependent antinociceptive response
• mutant mice treated with epibatidine do not exhibit an antinociceptive response in the hot plate test
• in contrast, nicotine causes a reduced but not absent dose-dependent analgesia in the tail flick test in mutant mice
• no significant differences in nociception are seen after morphine administration in mutant and control mice

integument
• latency response to painful stimuli in the hot plate test and tail flick test does not differ significantly between mutant and control mice
• mutant mice do not show an antinociceptive response to the hot plate test at any dose of nicotine, whereas control mice show a dose-dependent antinociceptive response
• mutant mice treated with epibatidine do not exhibit an antinociceptive response in the hot plate test
• in contrast, nicotine causes a reduced but not absent dose-dependent analgesia in the tail flick test in mutant mice
• no significant differences in nociception are seen after morphine administration in mutant and control mice

immune system
N
• IgM levels of preimmune serum are little altered from control levels
• increased IgG response to cytochrome c
• significantly reduced preimmune serum Ig levels
• preimmune actin and myosin binding antibody is significantly reduced

hematopoietic system
• increased IgG response to cytochrome c
• significantly reduced preimmune serum Ig levels
• preimmune actin and myosin binding antibody is significantly reduced





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/04/2020
MGI 6.15
The Jackson Laboratory