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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
nma
neuromuscular ataxia
MGI:1889328
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
nma/nma B6C3Fe a/a-nma/J MGI:3709341


Genotype
MGI:3709341
hm1
Allelic
Composition
nma/nma
Genetic
Background
B6C3Fe a/a-nma/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
nma mutation (1 available); any nma mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Smaller size and awkward position of the limbs of nma/nma (left) mice

mortality/aging

growth/size/body
• small size is noticeable by 12 days of age
• mutants weigh 50% less than control littermates

behavior/neurological
• when picked up the tail, the rear legs are held in an extended position for a brief period and then the legs clasp
• rear legs are overextended when sitting and extend beyond the front legs when walking
• mutants have problems maintaining their balance and appear to prop themselves up in the shavings or against the cage wall when sitting
• when placed in water, mutants cannot orient body position and go to the bottom of the container in a rolling spiral
• mutants are frail and exhibit a general weakness
• weakness in the hindlimbs that causes mutant to fall to one side and then the other

homeostasis/metabolism
• significantly reduced blood glucose

nervous system
N
• although the behavioral abnormalities appear similar to mice that have cerebellum abnormalities, brain sections reveal no abnormalities, especially in the cerebellum

muscle
N
• skeletal muscle shows no muscular dystrophy or neurogenic atrophy

hearing/vestibular/ear
N
• normal hearing and ears





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory