All Phenotypes Scrib<Crc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scrib^Crc
circletail
MGI:1889322

Summary

15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scrib^Crc/Scrib^Crc	C3H.Cg-Scrib^Crc	MGI:5661726
hm2	Scrib^Crc/Scrib^Crc	involves: BALB/c * C57BL/6 * CBA/CaJ * NMRI	MGI:3797038
hm3	Scrib^Crc/Scrib^Crc	involves: BALB/c * C57BL/6 * NMRI	MGI:3619999
hm4	Scrib^Crc/Scrib^Crc	involves: C3H/HeH * C57BL/6 * C57BL/6J * NMRI	MGI:5661718
hm5	Scrib^Crc/Scrib^Crc	involves: C57BL/6J * NMRI	MGI:4415138
ht6	Scrib^Crc/Scrib⁺	C3H.Cg-Scrib^Crc	MGI:5661729
ht7	Scrib^Crc/Scrib⁺	involves: BALB/c * C57BL/6 * NMRI	MGI:3619997
ht8	Scrib^Crc/Scrib⁺	involves: C57BL/6J * NMRI	MGI:4415139
cx9	Celsr1^Crsh/Celsr1⁺ Scrib^Crc/Scrib⁺	C3H.Cg-Scrib^Crc Celsr1^Crsh	MGI:5661818
cx10	Celsr1^Scy/Celsr1⁺ Scrib^Crc/Scrib⁺	C3H.Cg-Scrib^Crc Celsr1^Scy	MGI:5661820
cx11	Scrib^Crc/Scrib⁺ Vangl2^Lp/Vangl2⁺	C3H.Cg-Vangl2^Lp Scrib^Crc	MGI:5661815
cx12	Celsr1^Crsh/Celsr1⁺ Scrib^Crc/Scrib⁺ Vangl2^Lp/Vangl2⁺	C3H.Cg-Vangl2^Lp Scrib^Crc Celsr1^Crsh	MGI:5661822
cx13	Celsr1^Crsh/Celsr1⁺ Scrib^Crc/Scrib⁺	involves: 101/H * BALB/c * C3H/HeH * C57BL/6 * NMRI	MGI:5661724
cx14	Scrib^Crc/Scrib⁺ Vangl2⁺/Vangl2^Lp	involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR	MGI:3797053
cx15	Gli3^TgBR/Gli3⁺ Scrib^Crc/Scrib^Crc	involves: C57BL/6J * NMRI	MGI:4415141

Allelic Composition	Scrib^Crc/Scrib^Crc
Genetic Background	C3H.Cg-Scrib^Crc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^Crc mutation (2 available); any Scrib mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

open neural tube ( J:216413 )

• all embryos fail to achieve neural tube closure 1 between the 5- and 8-somite stages

craniorachischisis ( J:216413 )

nervous system

open neural tube ( J:216413 )

• all embryos fail to achieve neural tube closure 1 between the 5- and 8-somite stages

craniorachischisis ( J:216413 )

Allelic Composition	Scrib^Crc/Scrib^Crc
Genetic Background	involves: BALB/c * C57BL/6 * CBA/CaJ * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^Crc mutation (2 available); any Scrib mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

craniorachischisis ( J:72608 )

embryo

craniorachischisis ( J:72608 )

Allelic Composition	Scrib^Crc/Scrib^Crc
Genetic Background	involves: BALB/c * C57BL/6 * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^Crc mutation (2 available); any Scrib mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:62635 )

• homozygotes die at birth

nervous system

craniorachischisis ( J:62635 )

• by E9, neural tube fails to close along its rostrocaudal length from midbrain to tail

• skin excision bordering neural tube is prominent

abnormal forebrain development ( J:62635 )

• outpouching of forebrain tissue

• distortion of lateral ventricles and disappearance of third ventricle over time

• optic chiasm tends to form more caudal to anterior commissure

• glial palisade at chiasm is wider and thicker and is interrupted by an unidentified knot of tissue

abnormal lateral ventricle morphology ( J:62635 )

• distortion of lateral ventricles

absent third ventricle ( J:62635 )

• disappearance of third ventricle over time

abnormal optic nerve innervation ( J:62635 )

• retinal axon projections form an H shaped optic chiasm at E15

• retinal axons project correctly toward the dorsal thalamus, but fail to terminate

abnormal optic chiasm morphology ( J:62635 )

• optic chiasm tends to form more caudal to anterior commissure

encephalomeningocele ( J:62635 )

• prominent encephalocele

embryo

delayed embryo turning ( J:62635 )

• several day delay with a severe rightward kink of the body axis that lessens after turning

decreased embryo size ( J:62635 )

• smaller in size than normal littermates

decreased embryo weight ( J:62635 )

• lower in weight than normal littermates

craniorachischisis ( J:62635 )

• by E9, neural tube fails to close along its rostrocaudal length from midbrain to tail

• skin excision bordering neural tube is prominent

vision/eye

abnormal optic nerve innervation ( J:62635 )

• retinal axon projections form an H shaped optic chiasm at E15

• retinal axons project correctly toward the dorsal thalamus, but fail to terminate

abnormal optic chiasm morphology ( J:62635 )

• optic chiasm tends to form more caudal to anterior commissure

microphthalmia ( J:62635 )

• observed at E15

absent eyelids ( J:62635 )

• eyelids do not form

abnormal retina morphology ( J:62635 )

• shrunken vitreous region

abnormal retina ganglion layer morphology ( J:62635 )

• disorganized distribution of retinal ganglion cells

• ganglion cell nuclei are smaller than wild-type at E15

increased total retina thickness ( J:62635 )

• thickened neural retina

growth/size/body

decreased embryo size ( J:62635 )

• smaller in size than normal littermates

decreased embryo weight ( J:62635 )

• lower in weight than normal littermates

herniated abdominal wall ( J:62635 )

• gastroschisis or externalization of abdominal contents observed in all embryos with craniorachischisis

Allelic Composition	Scrib^Crc/Scrib^Crc
Genetic Background	involves: C3H/HeH * C57BL/6 * C57BL/6J * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^Crc mutation (2 available); any Scrib mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

craniorachischisis ( J:216413 )

• fully penetrant

nervous system

craniorachischisis ( J:216413 )

• fully penetrant

Allelic Composition	Scrib^Crc/Scrib^Crc
Genetic Background	involves: C57BL/6J * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^Crc mutation (2 available); any Scrib mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:77245 )

• die at birth

growth/size/body

herniated abdominal wall ( J:77245 )

decreased fetal size ( J:77245 )

embryo

delayed embryo turning ( J:77245 )

craniorachischisis ( J:77245 )

nervous system

craniorachischisis ( J:77245 )

Allelic Composition	Scrib^Crc/Scrib⁺
Genetic Background	C3H.Cg-Scrib^Crc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^Crc mutation (2 available); any Scrib mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:216413 )

N	• embryos initiate neural tube closure similarly to wild-type embryos

Allelic Composition	Scrib^Crc/Scrib⁺
Genetic Background	involves: BALB/c * C57BL/6 * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^Crc mutation (2 available); any Scrib mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:62635 )

• in some mice, tail defect appears as a complete looping or circling of tail

• defect appears 10 fold more frequently in males

kinked tail ( J:62635 )

• in some mice, tail defect appears as a bend or kink in middle portion

• defect appears 10 fold more frequently in males

Allelic Composition	Scrib^Crc/Scrib⁺
Genetic Background	involves: C57BL/6J * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^Crc mutation (2 available); any Scrib mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

curly tail ( J:77245 )

• incomplete penetrance (about 5%) of circled-tail, almost exclusively in males

Allelic Composition	Celsr1^Crsh/Celsr1⁺ Scrib^Crc/Scrib⁺
Genetic Background	C3H.Cg-Scrib^Crc Celsr1^Crsh

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr1^Crsh mutation (1 available); any Celsr1 mutation (143 available)
Scrib^Crc mutation (2 available); any Scrib mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal developmental patterning ( J:216413 )

• skewed body axis in some mutants

spina bifida ( J:216413 )

• lumbosacral open spina bifida in 2% of mutants (1 of 41); this mouse shows partially closed eyelids

craniorachischisis ( J:216413 )

• 42% of mutants exhibit craniorachischisis, most often isolated (32% of mutants) but sometimes associated with abdominal wall defect and a skewed body axis (10% of mutants)

• however, 46% of mutants appear normal

growth/size/body

abnormal abdominal wall morphology ( J:216413 )

• abdominal wall defect in some mutants

limbs/digits/tail

curly tail ( J:216413 )

• 2% of mutants exhibit a looped tail

nervous system

spina bifida ( J:216413 )

• lumbosacral open spina bifida in 2% of mutants (1 of 41); this mouse shows partially closed eyelids

craniorachischisis ( J:216413 )

• 42% of mutants exhibit craniorachischisis, most often isolated (32% of mutants) but sometimes associated with abdominal wall defect and a skewed body axis (10% of mutants)

• however, 46% of mutants appear normal

exencephaly ( J:216413 )

• isolated exencephaly in 7% of mutants

vision/eye

abnormal eyelid morphology ( J:216413 )

• mutants with craniorachischisis show completely open eyelids at E16.5

abnormal eyelid development ( J:216413 )

• 50% of mutants (5 of 10) exhibit failure of eyelid formation at E16.5

• mutants with craniorachischisis show completely open eyelids

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neural tube defect		DOID:0080074	OMIM:301410 OMIM:601634	J:216413

Allelic Composition	Celsr1^Scy/Celsr1⁺ Scrib^Crc/Scrib⁺
Genetic Background	C3H.Cg-Scrib^Crc Celsr1^Scy

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr1^Scy mutation (2 available); any Celsr1 mutation (143 available)
Scrib^Crc mutation (2 available); any Scrib mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

craniorachischisis ( J:216413 )

• 62% mutants exhibit craniorachischisis, most often isolated (in 56% of mutants), but sometimes associated with abdominal wall defect (6% of mutants)

• however, 39% mutants appear normal

growth/size/body

abnormal abdominal wall morphology ( J:216413 )

• 1 of 18 mutants with craniorachischisis show an abdominal wall defect

nervous system

craniorachischisis ( J:216413 )

• 62% mutants exhibit craniorachischisis, most often isolated (in 56% of mutants), but sometimes associated with abdominal wall defect (6% of mutants)

• however, 39% mutants appear normal

vision/eye

abnormal eyelid morphology ( J:216413 )

• some mutants with craniorachischisis show eyelid closure defects

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neural tube defect		DOID:0080074	OMIM:301410 OMIM:601634	J:216413

Allelic Composition	Scrib^Crc/Scrib⁺ Vangl2^Lp/Vangl2⁺
Genetic Background	C3H.Cg-Vangl2^Lp Scrib^Crc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^Crc mutation (2 available); any Scrib mutation (53 available)
Vangl2^Lp mutation (2 available); any Vangl2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal developmental patterning ( J:216413 )

• skewed body axis in some mutants

craniorachischisis ( J:216413 )

• 81% of mutants exhibit craniorachischisis, most often isolated (in 50% of mutants) but sometimes associated with abdominal wall defect (in 31% of mutants) and a skewed body axis

growth/size/body

abnormal abdominal wall morphology ( J:216413 )

• 3% of mutants exhibit only an abdominal wall defect while 31% exhibit both abdominal wall defect and craniorachischisis

limbs/digits/tail

curly tail ( J:216413 )

• 6% of mutants exhibit a looped tail

mortality/aging

prenatal lethality, incomplete penetrance ( J:216413 )

• 13% of mutants are viable postnatally

nervous system

craniorachischisis ( J:216413 )

• 81% of mutants exhibit craniorachischisis, most often isolated (in 50% of mutants) but sometimes associated with abdominal wall defect (in 31% of mutants) and a skewed body axis

exencephaly ( J:216413 )

• 3% of mutants exhibit exencephaly

vision/eye

abnormal eyelid morphology ( J:216413 )

• all mutants exhibit failure of eyelid closure at E16.5; all these have craniorachischisis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neural tube defect		DOID:0080074	OMIM:301410 OMIM:601634	J:216413

Allelic Composition	Celsr1^Crsh/Celsr1⁺ Scrib^Crc/Scrib⁺ Vangl2^Lp/Vangl2⁺
Genetic Background	C3H.Cg-Vangl2^Lp Scrib^Crc Celsr1^Crsh

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

craniorachischisis ( J:216413 )

• 2 of 3 mutants exhibit craniorachischisis

limbs/digits/tail

abnormal tail morphology ( J:216413 )

• 1 of 3 mice exhibits hindbrain exencephaly and a tail defect

nervous system

craniorachischisis ( J:216413 )

• 2 of 3 mutants exhibit craniorachischisis

exencephaly ( J:216413 )

• 1 of 3 mice exhibits hindbrain exencephaly and a tail defect

Allelic Composition	Celsr1^Crsh/Celsr1⁺ Scrib^Crc/Scrib⁺
Genetic Background	involves: 101/H * BALB/c * C3H/HeH * C57BL/6 * NMRI

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

craniorachischisis ( J:216413 )

• 8% of embryos develop craniorachischisis

nervous system

craniorachischisis ( J:216413 )

• 8% of embryos develop craniorachischisis

Allelic Composition	Scrib^Crc/Scrib⁺ Vangl2⁺/Vangl2^Lp
Genetic Background	involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:72608 )

craniorachischisis ( J:72608 )

• 29 of 54 double heterozygotes exhibit craniorachisichisis and the remainder had either spina bifida or a looped tail

limbs/digits/tail

curly tail ( J:72608 )

• in a small minority of double heterozygotes

embryo

spina bifida ( J:72608 )

craniorachischisis ( J:72608 )

• 29 of 54 double heterozygotes exhibit craniorachisichisis and the remainder had either spina bifida or a looped tail

Allelic Composition	Gli3^TgBR/Gli3⁺ Scrib^Crc/Scrib^Crc
Genetic Background	involves: C57BL/6J * NMRI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3^TgBR mutation (0 available); any Gli3 mutation (80 available)
Scrib^Crc mutation (2 available); any Scrib mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal innervation ( J:77245 )

• retinal axons project in circuitous, intersecting patterns across the retina before reaching the optic nerve head instead of a direct trajectory from their cell of origin toward the optic disk

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