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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
ScribCrc
circletail
MGI:1889322
Summary 15 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
ScribCrc/ScribCrc C3H.Cg-ScribCrc MGI:5661726
hm2
ScribCrc/ScribCrc involves: BALB/c * C57BL/6 * CBA/CaJ * NMRI MGI:3797038
hm3
ScribCrc/ScribCrc involves: BALB/c * C57BL/6 * NMRI MGI:3619999
hm4
ScribCrc/ScribCrc involves: C3H/HeH * C57BL/6 * C57BL/6J * NMRI MGI:5661718
hm5
ScribCrc/ScribCrc involves: C57BL/6J * NMRI MGI:4415138
ht6
ScribCrc/Scrib+ C3H.Cg-ScribCrc MGI:5661729
ht7
ScribCrc/Scrib+ involves: BALB/c * C57BL/6 * NMRI MGI:3619997
ht8
ScribCrc/Scrib+ involves: C57BL/6J * NMRI MGI:4415139
cx9
Celsr1Crsh/Celsr1+
ScribCrc/Scrib+
C3H.Cg-ScribCrc Celsr1Crsh MGI:5661818
cx10
Celsr1Scy/Celsr1+
ScribCrc/Scrib+
C3H.Cg-ScribCrc Celsr1Scy MGI:5661820
cx11
ScribCrc/Scrib+
Vangl2Lp/Vangl2+
C3H.Cg-Vangl2Lp ScribCrc MGI:5661815
cx12
Celsr1Crsh/Celsr1+
ScribCrc/Scrib+
Vangl2Lp/Vangl2+
C3H.Cg-Vangl2Lp ScribCrc Celsr1Crsh MGI:5661822
cx13
Celsr1Crsh/Celsr1+
ScribCrc/Scrib+
involves: 101/H * BALB/c * C3H/HeH * C57BL/6 * NMRI MGI:5661724
cx14
ScribCrc/Scrib+
Vangl2+/Vangl2Lp
involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR MGI:3797053
cx15
Gli3TgBR/Gli3+
ScribCrc/ScribCrc
involves: C57BL/6J * NMRI MGI:4415141


Genotype
MGI:5661726
hm1
Allelic
Composition
ScribCrc/ScribCrc
Genetic
Background
C3H.Cg-ScribCrc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ScribCrc mutation (2 available); any Scrib mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• all embryos fail to achieve neural tube closure 1 between the 5- and 8-somite stages

nervous system
• all embryos fail to achieve neural tube closure 1 between the 5- and 8-somite stages




Genotype
MGI:3797038
hm2
Allelic
Composition
ScribCrc/ScribCrc
Genetic
Background
involves: BALB/c * C57BL/6 * CBA/CaJ * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ScribCrc mutation (2 available); any Scrib mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

embryo




Genotype
MGI:3619999
hm3
Allelic
Composition
ScribCrc/ScribCrc
Genetic
Background
involves: BALB/c * C57BL/6 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ScribCrc mutation (2 available); any Scrib mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes die at birth

nervous system
• by E9, neural tube fails to close along its rostrocaudal length from midbrain to tail
• skin excision bordering neural tube is prominent
• outpouching of forebrain tissue
• distortion of lateral ventricles and disappearance of third ventricle over time
• optic chiasm tends to form more caudal to anterior commissure
• glial palisade at chiasm is wider and thicker and is interrupted by an unidentified knot of tissue
• distortion of lateral ventricles
• disappearance of third ventricle over time
• retinal axon projections form an H shaped optic chiasm at E15
• retinal axons project correctly toward the dorsal thalamus, but fail to terminate
• optic chiasm tends to form more caudal to anterior commissure
• prominent encephalocele

embryo
• several day delay with a severe rightward kink of the body axis that lessens after turning
• smaller in size than normal littermates
• lower in weight than normal littermates
• by E9, neural tube fails to close along its rostrocaudal length from midbrain to tail
• skin excision bordering neural tube is prominent

vision/eye
• retinal axon projections form an H shaped optic chiasm at E15
• retinal axons project correctly toward the dorsal thalamus, but fail to terminate
• optic chiasm tends to form more caudal to anterior commissure
• observed at E15
• eyelids do not form
• shrunken vitreous region
• disorganized distribution of retinal ganglion cells
• ganglion cell nuclei are smaller than wild-type at E15
• thickened neural retina

growth/size/body
• smaller in size than normal littermates
• lower in weight than normal littermates
• gastroschisis or externalization of abdominal contents observed in all embryos with craniorachischisis




Genotype
MGI:5661718
hm4
Allelic
Composition
ScribCrc/ScribCrc
Genetic
Background
involves: C3H/HeH * C57BL/6 * C57BL/6J * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ScribCrc mutation (2 available); any Scrib mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• fully penetrant

nervous system
• fully penetrant




Genotype
MGI:4415138
hm5
Allelic
Composition
ScribCrc/ScribCrc
Genetic
Background
involves: C57BL/6J * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ScribCrc mutation (2 available); any Scrib mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body

embryo

nervous system




Genotype
MGI:5661729
ht6
Allelic
Composition
ScribCrc/Scrib+
Genetic
Background
C3H.Cg-ScribCrc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ScribCrc mutation (2 available); any Scrib mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• embryos initiate neural tube closure similarly to wild-type embryos




Genotype
MGI:3619997
ht7
Allelic
Composition
ScribCrc/Scrib+
Genetic
Background
involves: BALB/c * C57BL/6 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ScribCrc mutation (2 available); any Scrib mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• in some mice, tail defect appears as a complete looping or circling of tail
• defect appears 10 fold more frequently in males
• in some mice, tail defect appears as a bend or kink in middle portion
• defect appears 10 fold more frequently in males




Genotype
MGI:4415139
ht8
Allelic
Composition
ScribCrc/Scrib+
Genetic
Background
involves: C57BL/6J * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ScribCrc mutation (2 available); any Scrib mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• incomplete penetrance (about 5%) of circled-tail, almost exclusively in males




Genotype
MGI:5661818
cx9
Allelic
Composition
Celsr1Crsh/Celsr1+
ScribCrc/Scrib+
Genetic
Background
C3H.Cg-ScribCrc Celsr1Crsh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr1Crsh mutation (1 available); any Celsr1 mutation (8 available)
ScribCrc mutation (2 available); any Scrib mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• skewed body axis in some mutants
• lumbosacral open spina bifida in 2% of mutants (1 of 41); this mouse shows partially closed eyelids
• 42% of mutants exhibit craniorachischisis, most often isolated (32% of mutants) but sometimes associated with abdominal wall defect and a skewed body axis (10% of mutants)
• however, 46% of mutants appear normal

growth/size/body
• abdominal wall defect in some mutants

limbs/digits/tail
• 2% of mutants exhibit a looped tail

nervous system
• lumbosacral open spina bifida in 2% of mutants (1 of 41); this mouse shows partially closed eyelids
• 42% of mutants exhibit craniorachischisis, most often isolated (32% of mutants) but sometimes associated with abdominal wall defect and a skewed body axis (10% of mutants)
• however, 46% of mutants appear normal
• isolated exencephaly in 7% of mutants

vision/eye
• mutants with craniorachischisis show completely open eyelids at E16.5
• 50% of mutants (5 of 10) exhibit failure of eyelid formation at E16.5
• mutants with craniorachischisis show completely open eyelids

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
neural tube defect DOID:0080074 OMIM:182940
OMIM:301410
OMIM:601634
J:216413




Genotype
MGI:5661820
cx10
Allelic
Composition
Celsr1Scy/Celsr1+
ScribCrc/Scrib+
Genetic
Background
C3H.Cg-ScribCrc Celsr1Scy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr1Scy mutation (2 available); any Celsr1 mutation (8 available)
ScribCrc mutation (2 available); any Scrib mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• 62% mutants exhibit craniorachischisis, most often isolated (in 56% of mutants), but sometimes associated with abdominal wall defect (6% of mutants)
• however, 39% mutants appear normal

growth/size/body
• 1 of 18 mutants with craniorachischisis show an abdominal wall defect

nervous system
• 62% mutants exhibit craniorachischisis, most often isolated (in 56% of mutants), but sometimes associated with abdominal wall defect (6% of mutants)
• however, 39% mutants appear normal

vision/eye
• some mutants with craniorachischisis show eyelid closure defects

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
neural tube defect DOID:0080074 OMIM:182940
OMIM:301410
OMIM:601634
J:216413




Genotype
MGI:5661815
cx11
Allelic
Composition
ScribCrc/Scrib+
Vangl2Lp/Vangl2+
Genetic
Background
C3H.Cg-Vangl2Lp ScribCrc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ScribCrc mutation (2 available); any Scrib mutation (32 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• skewed body axis in some mutants
• 81% of mutants exhibit craniorachischisis, most often isolated (in 50% of mutants) but sometimes associated with abdominal wall defect (in 31% of mutants) and a skewed body axis

growth/size/body
• 3% of mutants exhibit only an abdominal wall defect while 31% exhibit both abdominal wall defect and craniorachischisis

limbs/digits/tail
• 6% of mutants exhibit a looped tail

mortality/aging
• 13% of mutants are viable postnatally

nervous system
• 81% of mutants exhibit craniorachischisis, most often isolated (in 50% of mutants) but sometimes associated with abdominal wall defect (in 31% of mutants) and a skewed body axis
• 3% of mutants exhibit exencephaly

vision/eye
• all mutants exhibit failure of eyelid closure at E16.5; all these have craniorachischisis

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
neural tube defect DOID:0080074 OMIM:182940
OMIM:301410
OMIM:601634
J:216413




Genotype
MGI:5661822
cx12
Allelic
Composition
Celsr1Crsh/Celsr1+
ScribCrc/Scrib+
Vangl2Lp/Vangl2+
Genetic
Background
C3H.Cg-Vangl2Lp ScribCrc Celsr1Crsh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr1Crsh mutation (1 available); any Celsr1 mutation (8 available)
ScribCrc mutation (2 available); any Scrib mutation (32 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• 2 of 3 mutants exhibit craniorachischisis

limbs/digits/tail
• 1 of 3 mice exhibits hindbrain exencephaly and a tail defect

nervous system
• 2 of 3 mutants exhibit craniorachischisis
• 1 of 3 mice exhibits hindbrain exencephaly and a tail defect




Genotype
MGI:5661724
cx13
Allelic
Composition
Celsr1Crsh/Celsr1+
ScribCrc/Scrib+
Genetic
Background
involves: 101/H * BALB/c * C3H/HeH * C57BL/6 * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Celsr1Crsh mutation (1 available); any Celsr1 mutation (8 available)
ScribCrc mutation (2 available); any Scrib mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• 8% of embryos develop craniorachischisis

nervous system
• 8% of embryos develop craniorachischisis




Genotype
MGI:3797053
cx14
Allelic
Composition
ScribCrc/Scrib+
Vangl2+/Vangl2Lp
Genetic
Background
involves: BALB/c * C57BL/6 * CBA/Ca * LPT/LeJ * NMRI * SWR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ScribCrc mutation (2 available); any Scrib mutation (32 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 29 of 54 double heterozygotes exhibit craniorachisichisis and the remainder had either spina bifida or a looped tail

limbs/digits/tail
• in a small minority of double heterozygotes

embryo
• 29 of 54 double heterozygotes exhibit craniorachisichisis and the remainder had either spina bifida or a looped tail




Genotype
MGI:4415141
cx15
Allelic
Composition
Gli3TgBR/Gli3+
ScribCrc/ScribCrc
Genetic
Background
involves: C57BL/6J * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gli3TgBR mutation (0 available); any Gli3 mutation (10 available)
ScribCrc mutation (2 available); any Scrib mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• retinal axons project in circuitous, intersecting patterns across the retina before reaching the optic nerve head instead of a direct trajectory from their cell of origin toward the optic disk





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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory