• at P2, homozygotes display normal numbers of sensory neurons in trigeminal ganglia and L6 lumbar dorsal root ganglia relative to wild-type controls (J:86439)

• homozygotes exhibit normal morphology and numbers of myelinated A-fibers and unmyelinated C-fibers in adult saphenous nerves relative to wild-type controls (J:86439)

• in culture, neurons from P2 peripheral (trigeminal and superior cervical) ganglia of mutant mice display the same survival rate as wild-type neurons in the presence of nerve growth factor and, as expected, fail to survive in its absence (J:86439)

• homozygotes display no gross abnormalities of the nervous system relative to wild-type controls (J:92213)

• no significant differences in dopamine or its metabolite (DOPAC, 5-HIAA and HVA) levels are noted in the striatum at 9 months of age (J:92213)

• homozygotes display resistance of SNpc dopaminergic neurons to MPTP neurotoxicity

• adult homozygotes show a ~20% reduction in the number of tyrosine hydroxylase (TH)-positive dopaminergic neurons in substantia nigra pars compacta (SNpc) but not in ventral tegmental area (VTA) relative to wild-type controls, similar to that observed in adult Sncg^tm1Vlb homozygotes

• however, no significant decrease in the number of TH-positive dopaminergic neurons is observed in SNpc after methyl-phenyl-tetrahydropyridine (MPTP) treatment relative to controls

• homozygotes display resistance of SNpc dopaminergic neurons to MPTP neurotoxicity

• homozygotes are behaviorally normal and show no detectable motor dysfunction in either constant speed or accelerating rotarod tests (J:92213)

• homozygotes display resistance of SNpc dopaminergic neurons to MPTP neurotoxicity

• mice do not exhibit as much dopamine neuron loss following injection of LPS into the substantia nigra as similarly treated wild-type mice

• dopamine content is reduced by 18% in the striatum, however, dopamine content in the ventral midbrain and nucleus accumbens is similar to wild-type

• when exposed to paired electrical stimuli, striatal brain slices (containing dopamine terminals) from homozygous mice exhibit a faster dopamine release recovery as compared to wild-type

• dopamine discharge and reuptake in response to a single electrical pulse or a train of pulses is comparable to wild-type

• homozygous mice exhibit an attenuated locomotor response after administration of amphetamine as compared to wild-type

• in the absence of amphetamine, locomotor activity in the open field test is comparable to wild-type

• dopamine content is reduced by 18% in the striatum, however, dopamine content in the ventral midbrain and nucleus accumbens is similar to wild-type

• double homozygotes are viable, fertile and display no gross abnormalities of the nervous system (J:92213)

• no significant differences in dopamine or its metabolite (DOPAC, 5-HIAA and HVA) levels are noted in the striatum at 9 months of age (J:92213)

• similar to single homozygotes, double homozygotes display resistance of SNpc dopaminergic neurons to MPTP neurotoxicity

• adult double homozygotes show a ~20% reduction in the number of tyrosine hydroxylase (TH)-positive dopaminergic neurons in substantia nigra pars compacta (SNpc) but not in ventral tegmental area (VTA) relative to wild-type controls, similar to that observed in adult single homozygotes

• however, no significant decrease in the number of TH-positive dopaminergic neurons is observed in SNpc after methyl-phenyl-tetrahydropyridine (MPTP) treatment relative to controls

• similar to single homozygotes, double homozygotes display resistance of SNpc dopaminergic neurons to MPTP neurotoxicity

• double homozygotes are behaviorally normal and show no detectable motor dysfunction in either constant speed or accelerating rotarod tests (J:92213)

• similar to single homozygotes, double homozygotes display resistance of SNpc dopaminergic neurons to MPTP neurotoxicity

• following injection of LPS into the substantia nigra

• following injection of LPS into the substantia nigra, mice exhibit an increased loss of dopaminergic neurons that is associated with insoluble and aggregated SNCA compared to in Snca^tm1Rosl Tg(Prnp-SNCA)7Vle and Snca^tm1Rosl homozygotes

• however, loss of dopamine neurons is not due to an abnormal inflammatory response following injection of LPS into the substantia nigra

• following injection of LPS into the substantia nigra, mice exhibit an increased loss of dopaminergic neurons compared to in Snca^tm1Rosl Tg(Prnp-SNCA)7Vle and Snca^tm1Rosl homozygotes

• following injection of LPS into the substantia nigra

• following injection of LPS into the substantia nigra, mice exhibit an increased loss of dopaminergic neurons that is associated with insoluble and aggregated SNCA compared to in Snca^tm1Rosl homozygotes

• following culture with LPS, dopaminergic neurons loss is increased compared to in cultures from Snca^tm1Rosl homozygotes

• loss of dopamine neurons following injection of LPS into the substantia nigra is mediated by microglial-derived nitric oxide and superoxideloss of dopamine neurons following injection of LPS into the substantia nigra is mediated by microglial-derived nitric oxide and superoxide

• however, loss of dopamine neurons is not due to an abnormal inflammatory response following injection of LPS into the substantia nigra

• following injection of LPS into the substantia nigra, mice exhibit a decreased loss of dopaminergic neurons compared to in Snca^tm1Rosl Tg(Prnp-SNCA*A53T)83Vle homozygotes but increased relative to in Snca^tm1Rosl homozygotes