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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Aff1Rob
robotic
MGI:1862020
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Aff1Rob/Aff1+ involves: BALB/cAnNCrl * C3H/HeN MGI:2174716


Genotype
MGI:2174716
ht1
Allelic
Composition
Aff1Rob/Aff1+
Genetic
Background
involves: BALB/cAnNCrl * C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aff1Rob mutation (2 available); any Aff1 mutation (272 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• the skewed ratio of mutant pups that reach weaning suggests a prenatal and postnatal death rate of around 20%

behavior/neurological
• by about 3 weeks of age mutants have a jerky, ataxic gait
• at 5 weeks of age performance in the rotarod test is significantly impaired
• robotic movement

growth/size/body
• by about 3 weeks of age mutants are approximately 50% of the size of their littermates

hematopoietic system
• thymus weight is significantly lower in mutants compared to littermate controls
• thymus cellularity is significantly lower in mutants compared to littermate controls
• a significant increase in DN CD25+/CD44- and decrease in DN CD25-/CD44+ is seen

immune system
• thymus weight is significantly lower in mutants compared to littermate controls
• thymus cellularity is significantly lower in mutants compared to littermate controls
• a significant increase in DN CD25+/CD44- and decrease in DN CD25-/CD44+ is seen

reproductive system
• females fail to carry pups to term
• males mated to wild-type females sire small litters

vision/eye
• complete, bilateral cataracts develop

nervous system
• the size of the cerebellum is reduced at 42 weeks of age
• Purkinje cell loss in a region specific pattern in the vermis, with the anterior cerebellum more severely affected is seen from 8 weeks of age on
• by 42 weeks of age only 30% of the Purkinje cells remain primarily in lobe X
• swelling of the dendrites begins at 3 weeks and is followed by swelling of the cell bodies and focal swellings of the cell axons
• from 10 weeks onward, the size of the molecular layer is decreased probably as a result of Purkinje cell loss and increased density of basket and stellate cells
• induction of Gfap, indicative of gliosis, is seen from 8 weeks onward

endocrine/exocrine glands
• thymus weight is significantly lower in mutants compared to littermate controls
• thymus cellularity is significantly lower in mutants compared to littermate controls





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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory