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Allele Symbol Allele Name Allele ID |
Lyntm1Sor targeted mutation 1, Philippe Soriano MGI:1861966 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice exhibit a modest reduction in hemorrhages compared to the thrombohemorrhagic vasculitis observed in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• B cell proliferation is more sensitive to anti-IgM than wild-type B cells
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• at 14 weeks of age
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• mice exhibit a decrease in conventional B cells due to increased higher turnover rates than in wild-type mice
• peripheral B cell numbers are reduced by 50% to 70% of wild-type
• B220loHSAhi B lymphocytes are decreased 2- to 5-fold in lymphoid compartments
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• at 14 weeks of age, splenomegaly is often accompanied by enlargments of the lymph nodes with lymphoblasts and plasma cells
• blast cells within the lymph node are activated and have a B1 identity
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• mice develop anti-dsDNA antibodies around 16 weeks of age unlike wild-type mice
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• B cell proliferation is more sensitive to anti-IgM than wild-type B cells
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• at 14 weeks of age
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• mice exhibit a decrease in conventional B cells due to increased higher turnover rates than in wild-type mice
• peripheral B cell numbers are reduced by 50% to 70% of wild-type
• B220loHSAhi B lymphocytes are decreased 2- to 5-fold in lymphoid compartments
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• at 14 weeks of age
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• B cell proliferation is more sensitive to anti-IgM than wild-type B cells
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Lupus-like autoimmune disease in Lyntm1Sor/Lyntm1Sor and Lyntm1.1Calo/Lyntm1.1Calo Top2aGt(PST14568)Mfgc/0 mice
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• B cells form mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation and LPS
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• mice develop splenomegaly with age due to myeloid hyperplasia
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• increase in the number of CD19lo/- CD138hi plasma cells in the spleen
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• reduced numbers of T1 and T2 B cells are found in the spleen
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• peripheral B cell numbers are reduced by almost 10-fold
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• reduced by about 10-fold in the spleen
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• reduced numbers in the spleen
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• mice have elevated levels of IgA in sera
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• mice have elevated levels of IgM in sera
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• fibrillar beta-amyloid stimulated reactive oxygen species production is reduced 70% compared to in wild-type cells
• however, response to zymosan and macrophage recruitment are normal
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• fibrillar beta-amyloid stimulated microglial recruitment is reduced 3-fold compared to in wild-type mice
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• increased levels of granulocyte and granulocyte macrophage colony stimulating factors at 6 months of age
• high levels of circulating B-cell activating factor
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• increased levels of a number of chemokines at 6 months of age
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• at 6 months of age
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• at 6 months of age
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• at 6 months of age
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• at 6 months of age
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• fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced by 50% compared to in wild-type mice
• however, macrophage production of MCP-1 in response to LPS or reverse beta-amyloid is normal
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• splenic dendritic cells produce more proinflammatory cytokines and more chemokines
• CD11chi DCs are hyperresponsive to cytokine stimulation
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• high levels of autoreactive antibodies in the serum
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• serum levels of anti-dsDNA antibodies increase with age with high levels occurring by 12 months of age
• levels of anti-dsDNA antibodies are below those of age-matched Lyn null homozygotes
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• IgG depositions in the liver occur in older mice though no associated pathology is observed
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• mice develop severe glomerulonephritis around 8 months of age
(J:146161)
• disease includes enlarged glomeruli, glomerular, hypercellularity, lobularity and sclerosis, mesangial interposition in peripheral capillary loops, and strong IgG deposition in the glomeruli
(J:146161)
• glomerulonephritis without interstitial inflammation is seen by 8-10 months of age
(J:200745)
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• fibrillar beta-amyloid stimulated microglial recruitment is reduced 3-fold compared to in wild-type mice
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• mesangial interposition in peripheral capillary loops
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• mice develop severe glomerulonephritis around 8 months of age
(J:146161)
• disease includes enlarged glomeruli, glomerular, hypercellularity, lobularity and sclerosis, mesangial interposition in peripheral capillary loops, and strong IgG deposition in the glomeruli
(J:146161)
• glomerulonephritis without interstitial inflammation is seen by 8-10 months of age
(J:200745)
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• deposition of C3 in the glomeruli
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• enlarged glomeruli
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• IgG depositions in the liver occur in older mice though no associated pathology is observed
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• B cells form mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation and LPS
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• mice develop splenomegaly with age due to myeloid hyperplasia
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• mice exhibit an accumulation of erythroid progenitor cells in the Kit+CD71high compartment compared to in wild-type mice
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• the ratio of Kit+ to Kit- proerythroblasts is increased compared to in wild-type mice
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• increase in the number of CD19lo/- CD138hi plasma cells in the spleen
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• reduced numbers of T1 and T2 B cells are found in the spleen
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• peripheral B cell numbers are reduced by almost 10-fold
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• reduced by about 10-fold in the spleen
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• reduced numbers in the spleen
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• mice have elevated levels of IgA in sera
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• mice have elevated levels of IgM in sera
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• fibrillar beta-amyloid stimulated reactive oxygen species production is reduced 70% compared to in wild-type cells
• however, response to zymosan and macrophage recruitment are normal
|
|
• fibrillar beta-amyloid stimulated microglial recruitment is reduced 3-fold compared to in wild-type mice
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• increased levels of granulocyte and granulocyte macrophage colony stimulating factors at 6 months of age
• high levels of circulating B-cell activating factor
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• increased levels of a number of chemokines at 6 months of age
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• at 6 months of age
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• at 6 months of age
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• at 6 months of age
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• at 6 months of age
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• fibrillar beta-amyloid stimulated MCP-1 production in macrophages is reduced by 50% compared to in wild-type mice
• however, macrophage production of MCP-1 in response to LPS or reverse beta-amyloid is normal
|
|
• mesangial interposition in peripheral capillary loops
|
|
• B cells form mice 7- to 11- weeks of age hyperproliferate in response to anti-IgM stimulation and LPS
|
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• mice develop splenomegaly with age due to myeloid hyperplasia
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in response to BCR ligation
• however, B cell proliferation in response to LPS stimulation is normal
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• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
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• in the serum and kidney deposits
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• in response to BCR ligation
• however, B cell proliferation in response to LPS stimulation is normal
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• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
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• in the serum and kidney deposits
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• in response to BCR ligation
• however, B cell proliferation in response to LPS stimulation is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• neutrophil degranulation after adhesion is decreased compared to in wild-type mice
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• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice exhibit no hemorrhages and reduced fibrin deposition compared to the thrombohemorrhagic vasculitis observed in wild-type mice
• however, neutrophil migration is normal
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• neutrophil degranulation after adhesion is decreased compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm1Mnz mice
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• antigen-specific B cell proliferation is enhanced compared to Ightm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization
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• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm1Mnz mice
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• antigen-specific B cell proliferation is enhanced compared to Ightm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization
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• antigen-specific B cell proliferation is enhanced compared to Ightm1Mnz mice that are CD19-wild-type (56.8% of B cells are Ig lambda+ vs 40%)
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm2Mnz mice
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• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization
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• number of B cells differentiating into germinal center B cells and plasmacytes is diminished compared to Ightm2Mnz mice
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• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization
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• antigen specific B cell proliferation is similar to wild-type CD19 Ightm2Mnz mice
• expansion is prolonged with increased levels of Ig lambda+ cells remaining 12 days after immunization
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• IgA, IgM, and IgG levels are the same as in wild-type mice
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• in response to BCR ligation or LPS stimulation
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• but not as much as in Lyntm1Sor homozygotes
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• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
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• bone marrow exhibit a decrease in IgM+ B220high compared with wild-type mice
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• after immunization, anti-DNP IgM antibody production is delayed compared with wild-type mice
• IgG1 response is delayed and modest compared to in wild-type mice
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• compared with Lyntm1Sor homozygotes
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• compared with Lyntm1Sor homozygotes
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• in response to BCR ligation or LPS stimulation
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• but not as much as in Lyntm1Sor homozygotes
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• bone marrow exhibit a modest decrease in IgM-B220low pro/pre B cells or IgM+ B220low immature B cells compared with wild-type mice
• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice
|
|
• bone marrow exhibit a decrease in IgM+ B220high compared with wild-type mice
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• in response to BCR ligation or LPS stimulation
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• but not as much as in Lyntm1Sor homozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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