All Phenotypes Itgb7<tm1Cgn> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itgb7^tm1Cgn/Itgb7^tm1Cgn	C57BL/6-Itgb7^tm1Cgn/J	MGI:3764689
hm2	Itgb7^tm1Cgn/Itgb7^tm1Cgn	involves: C57BL/6	MGI:2180884
cn3	Itgav^tm1Blb/Itgav^tm1Blb Itgb1^tm1Ref/Itgb1^tm1Ref Itgb2^tm2Bay/Itgb2^tm2Bay Itgb7^tm1Cgn/Itgb7^tm1Cgn Tg(Mx1-cre)1Cgn/0	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA	MGI:4358370
cx4	Itgb7^tm1Cgn/Itgb7^tm1Cgn Tnf^tm2Gkl/Tnf⁺	involves: 129S/SvEv * C57BL/6	MGI:3799636

Allelic Composition	Itgb7^tm1Cgn/Itgb7^tm1Cgn
Genetic Background	C57BL/6-Itgb7^tm1Cgn/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb7^tm1Cgn mutation (3 available); any Itgb7 mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte migration ( J:127413 )

• labeled splenocytes have greatly reduced migration rates to the small and large intestine after intravenous injection into congenic hosts

colitis ( J:127413 )

• only a mild form of colitis develops when nave CD4 T cells from these mice are transferred to immunocompromised mice as opposed to the robust colitis that occurs when the T cells come from wild-type mice

• the number of transferred T cells found in the large intestine is reduced by two-thirds

digestive/alimentary system

colitis ( J:127413 )

• the number of transferred T cells found in the large intestine is reduced by two-thirds

cellular

abnormal leukocyte migration ( J:127413 )

• labeled splenocytes have greatly reduced migration rates to the small and large intestine after intravenous injection into congenic hosts

hematopoietic system

abnormal leukocyte migration ( J:127413 )

• labeled splenocytes have greatly reduced migration rates to the small and large intestine after intravenous injection into congenic hosts

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:111227 )

N	• eosinophilic response to DSS treatment is normal

abnormal immune system morphology ( J:34306 )

abnormal uterine NK cell morphology ( J:44813 )

• uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)

increased uterine NK cell number ( J:44813 )

• a slight increase in uterine NK cells of 144% is present in the decidua basalis

decreased eosinophil cell number ( J:62733 )

• 4eosinophil numbers are lower upon infection by T. spiralis compared to wild-type mice; eosinophilia is delayed and reduced in Itgb7-deficient mice

decreased mast cell number ( J:62733 )

• mast cell numbers are lower upon infection by T. spiralis compared to wild-type; mastocytosis is reduced and delayed in Itgb7-deficient mice

decreased B cell number ( J:34306 )

• the number of IgA+ and IgM+ B cells and plasma cells are decreased 10 to 30-fold

• number of IgM+ cells in the Peyer's patches is decreased compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:34306 )

• the number of CD4+ cells in the lamina propria is decreased compared to in wild-type mice

abnormal gut-associated lymphoid tissue morphology ( J:34306 )

• mice exhibit hypoplasia of gut-associated lymphoid tissue

abnormal Peyer's patch follicle morphology ( J:34306 )

• rudimentary follicles do not disrupt the contour of the intestinal wall

small Peyer's patches ( J:34306 )

• microscopically, Peyer's patches are reduced to 10 to 20% of wild-type despite having an increased bacterial load compared to wild-type mice

• the cellularity of Peyer's patches is reduced

• however, the number of Peyer's patches is normal

abnormal immune system physiology ( J:34306 )

impaired leukocyte tethering or rolling ( J:34306 )

• leukocyte rolling velocity in high endothelial venules of Peyer's patches increased compared to in wild-type mice

• leukocyte rolling and adhesion are defective

abnormal lymphocyte physiology ( J:34306 )

• lymphocyte migration into Peyer's patches is almost abolished and is reduced by 49% in mesenteric lymph nodes compared to in wild-type mice

abnormal response to infection ( J:62733 )

• worm expulsion is impaired (delayed) in null mice

• when primed mesenteric lymph node cells are transferred into infected wild-type mice, recipients receiving wild-type cells show significantly enhanced worm expulsion compared to those receiving Itgb7-deficient MLN cells

• when wild-type or null primed mesenteric lymph node cells are transferred into knockout recipients which are infected 1 day later, there is no protective effect conferred by wild-type cells compared to Itgb7-deficient cells

increased susceptibility to parasitic infection ( J:90262 )

reproductive system

abnormal uterine NK cell morphology ( J:44813 )

• uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)

increased uterine NK cell number ( J:44813 )

• a slight increase in uterine NK cells of 144% is present in the decidua basalis

abnormal myometrium morphology ( J:44813 )

• while a typical metrial gland is not observed at E10, mice possess thickened myometrium with some PAS-reactive uterine NK cells

• at E14 implantation sites are poorly organized, a metrial gland develops but contains more smooth muscle fibers and fewer uterine NK cells than in wild-type mice

embryo

increased trophoblast giant cell number ( J:44813 )

• trophoblast giant cells are increased in number compared to in wild-type mice

abnormal uterine NK cell morphology ( J:44813 )

• uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)

increased uterine NK cell number ( J:44813 )

• a slight increase in uterine NK cells of 144% is present in the decidua basalis

hematopoietic system

impaired leukocyte tethering or rolling ( J:34306 )

• leukocyte rolling velocity in high endothelial venules of Peyer's patches increased compared to in wild-type mice

• leukocyte rolling and adhesion are defective

abnormal uterine NK cell morphology ( J:44813 )

• uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)

increased uterine NK cell number ( J:44813 )

• a slight increase in uterine NK cells of 144% is present in the decidua basalis

decreased eosinophil cell number ( J:62733 )

• 4eosinophil numbers are lower upon infection by T. spiralis compared to wild-type mice; eosinophilia is delayed and reduced in Itgb7-deficient mice

decreased mast cell number ( J:62733 )

• mast cell numbers are lower upon infection by T. spiralis compared to wild-type; mastocytosis is reduced and delayed in Itgb7-deficient mice

decreased B cell number ( J:34306 )

• the number of IgA+ and IgM+ B cells and plasma cells are decreased 10 to 30-fold

• number of IgM+ cells in the Peyer's patches is decreased compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:34306 )

• the number of CD4+ cells in the lamina propria is decreased compared to in wild-type mice

abnormal lymphocyte physiology ( J:34306 )

• lymphocyte migration into Peyer's patches is almost abolished and is reduced by 49% in mesenteric lymph nodes compared to in wild-type mice

cellular

impaired leukocyte tethering or rolling ( J:34306 )

• leukocyte rolling velocity in high endothelial venules of Peyer's patches increased compared to in wild-type mice

• leukocyte rolling and adhesion are defective

endocrine/exocrine glands

abnormal uterine NK cell morphology ( J:44813 )

• uterine NK cells are smaller than in wild-type mice at day 10 of gestation (20 to 25 um compared to 30 um in wild-type mice)

increased uterine NK cell number ( J:44813 )

• a slight increase in uterine NK cells of 144% is present in the decidua basalis

Allelic Composition	Itgav^tm1Blb/Itgav^tm1Blb Itgb1^tm1Ref/Itgb1^tm1Ref Itgb2^tm2Bay/Itgb2^tm2Bay Itgb7^tm1Cgn/Itgb7^tm1Cgn Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgav^tm1Blb mutation (0 available); any Itgav mutation (53 available)
Itgb1^tm1Ref mutation (0 available); any Itgb1 mutation (59 available)
Itgb2^tm2Bay mutation (3 available); any Itgb2 mutation (49 available)
Itgb7^tm1Cgn mutation (3 available); any Itgb7 mutation (72 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:134784 )

N	• following pIpC-induction, dendritic cells transplanted into the footpad exhibit normal drainage into lymph nodes

abnormal cellular extravasation ( J:134784 )

• abolished in pIpC-induced mice

abnormal dendritic cell physiology ( J:134784 )

• following pIpC-induction, dendritic cells fail to adhere to and migrate on a 2-D substrate unlike wild-type dendritic cells

• however, dendritic cells from pIpC-induced mice exhibit normal migration in 3D matrix

cellular

abnormal cellular extravasation ( J:134784 )

• abolished in pIpC-induced mice

hematopoietic system

abnormal cellular extravasation ( J:134784 )

• abolished in pIpC-induced mice

Allelic Composition	Itgb7^tm1Cgn/Itgb7^tm1Cgn Tnf^tm2Gkl/Tnf⁺
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb7^tm1Cgn mutation (3 available); any Itgb7 mutation (72 available)
Tnf^tm2Gkl mutation (1 available); any Tnf mutation (46 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal inflammatory response ( J:136667 )

• significant attenuation of the inflammatory bowel disease pathology with reduced acute and chronic inflammatory indices relative to mice heterozygous for Tnf^tm2Gkl alone

arthritis ( J:136667 )

• chronic inflammatory arthritis is similar to mice heterozygous for Tnf^tm2Gkl alone

skeleton

arthritis ( J:136667 )

• chronic inflammatory arthritis is similar to mice heterozygous for Tnf^tm2Gkl alone

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