About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Gt(ROSA)26Sortm1Sor
targeted mutation 1, Philippe Soriano
MGI:1861932
Summary 111 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor involves: 129S4/SvJaeSor MGI:2176735
cn2
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm2(icre/ERT2)Jphe involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 MGI:3803606
cn3
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Slc6a9tm1.1Caz/Slc6a9tm1.1Caz
B6.129P2-Slc6a9tm1.1Caz MGI:5085301
cn4
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns
H2az2Tg(Wnt1-cre)11Rth/0
B6.Cg-Ptpn11tm1.1Rbns Gt(ROSA)26Sortm1Sor H2az2Tg(Wnt1-cre)11Rth MGI:3852467
cn5
Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sortm1Sor
Tg(Mitf-cre)7114Gsb/0
C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sortm1Sor Tg(Mitf-cre)7114Gsb MGI:5702903
cn6
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm7(SMO*/YFP)Amc
Tg(CAG-cre/Esr1*)5Amc/0
chimera involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster MGI:4839957
cn7
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Ptf1atm1(cre)Cvw/Ptf1atm2Macd
involves: 129 MGI:3807487
cn8
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:5563244
cn9
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptentm1Mro/Ptentm1Mro
Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:5563247
cn10
Aurkatm1.1Tvd/Aurkatm1.1Tvd
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1Sor
involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J MGI:3836424
cn11
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Tie1-cre)9Ref/?
Gt(ROSA)26Sortm1Sor/?
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3767612
cn12
Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
Tg(Tie1-cre)9Ref/?
Gt(ROSA)26Sortm1Sor/?
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3767613
cn13
Hand2tm1Dsr/Hand2tm2.1Dsr
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Tbx1-cre)#Dsr/0
involves: 129 * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 MGI:4940095
cn14
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm1(cre/Esr1*)Krc/Isl1+
involves: 129 * 129S4/SvJaeSor * C57BL/6 MGI:3716982
cn15
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptentm1Mro/Ptentm1Mro
Rb1tm2Brn/Rb1tm2Brn
involves: 129 * 129S4/SvJaeSor * C57BL/6 * FVB MGI:5563246
cn16
Jag1tm1Frad/Jag1tm1Frad
Tg(Cdh5-cre)7Mlia/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129 * 129S4/SvJaeSor * FVB/N MGI:5447167
cn17
Notch1tm1Agt/Notch1tm1Agt
Tg(Cdh5-cre)7Mlia/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129 * 129S4/SvJaeSor * FVB/N MGI:5447168
cn18
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu
Tg(Pcp2-cre)3555Jdhu/0
involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N MGI:5304570
cn19
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Sox11tm2.1Weg/Sox11tm2.1Weg
Sox4tm1Vlf/Sox4tm1Vlf
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * C57BL/6J * CBA/J MGI:5285375
cn20
Ctnnb1tm2Kem/Ctnnb1tm3Kba
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * CBA/J MGI:5308956
cn21
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129 * C57BL/6 * CBA/J MGI:5308958
cn22
Cdh1tm1.1Mpst/Cdh1tm2Kem
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Vil1-cre)20Syr/0
involves: 129 * C57BL/6 * DBA/2 MGI:4822000
cn23
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Meis2tm1.1Zkoz/Meis2tm1.1Zkoz
Tfap2atm1(cre)Moon/Tfap2a+
involves: 129 * C57BL/6J MGI:5911951
cn24
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Pax7tm1.1Fan/Pax7tm2.1(cre/ERT2)Fan
involves: 129 * C57BL/6 * SJL MGI:4353176
cn25
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Tagln-cre)1Her/?
Gt(ROSA)26Sortm1Sor/?
involves: 129 * C57BL/6 * SJL MGI:3767614
cn26
Hif1atm3Rsjo/Hif1atm3Rsjo
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hprttm1(Pck1-cre)Vhh/Y
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ MGI:4418525
cn27
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptentm1Mro/Ptentm1Mro
Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor MGI:5790976
cn28
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hprttm1(Pbsn*-cre/ERT2)Jir/Hprt+
involves: 129P2/OlaHsd * 129S4/SvJaeSor MGI:3831282
cn29
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptentm1Mro/Ptentm1Mro
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S4/SvJaeSor MGI:5790977
cn30
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd MGI:3818077
cn31
Gata6osem3Zfa/Gata6osem3Zfa
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:6367573
cn32
Gata6osem1Zfa/Gata6osem1Zfa
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:6367570
cn33
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptentm1Mro/Ptentm1Mro
Trp53tm1Brn/Trp53tm1Brn
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB MGI:5563238
cn34
En1tm7(cre/ESR1)Alj/0
Fgf8tm1.3Mrt/Fgf8tm2.1Jyhl
Gt(ROSA)26Sortm1Sor/0
involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:4437229
cn35
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 MGI:3822771
cn36
En1tm7(cre/ESR1)Alj/En1+
En2tm2Alj/En2tm2Alj
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster MGI:3789333
cn37
Daam1tm1.1Tpy/Daam1tm1.1Tpy
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd MGI:6150944
cn38
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Prox1tm3(cre/ERT2)Gco/Prox1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 MGI:4441394
cn39
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss MGI:3695168
cn40
Kdrtm1Wag/Kdrtm1Wag
Nfatc1tm1.1(cre)Bz/Nfatc1+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 MGI:5471122
cn41
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
HhatTg(TFAP2A-cre)1Will/HhatTg(TFAP2A-cre)1Will
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA MGI:5447985
cn42
Fgf10tm1Ska/Fgf10tm1Sms
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Twist2tm1(cre)Dor/Twist2+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA MGI:3851799
cn43
Pitx2tm1.1Sac/Pitx2tm2Sac
H2az2Tg(Wnt1-cre)11Rth/?
Gt(ROSA)26Sortm1Sor/?
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA MGI:5298219
cn44
Fgf15tm1Sms/Fgf15tm1Sms
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA MGI:3639491
cn45
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hsd11b2tm1(cre)Anft/Hsd11b2+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL MGI:3701116
cn46
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * FVB/N MGI:5314779
cn47
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm2Sev/Isl1tm2Sev
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA MGI:3817490
cn48
Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL MGI:3840452
cn49
Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1.1Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL MGI:3840450
cn50
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tbx18tm4(cre)Akis/Tbx18+
involves: 129S1/SvImJ * 129S4/SvJaeSor MGI:3841148
cn51
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Evx2/Hoxd13tm4(cre)Ddu/Hoxd13+
involves: 129S2/SvPas MGI:3762357
cn52
Del(2Hoxd4-Hoxd13)28Ddu/+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S2/SvPas MGI:3762355
cn53
Del(2Hoxd11-Hoxd13)27Ddu/+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S2/SvPas MGI:3762353
cn54
Evx2/Hoxd13tm4(cre)Ddu/Evx2+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S2/SvPas MGI:3762358
cn55
Ntrk2tm2Kln/Ntrk2tm2Kln
Slc1a3tm1(cre/ERT2)Mgoe/?
Gt(ROSA)26Sortm1Sor/?
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL MGI:3830091
cn56
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tbx18tm4(cre)Akis/Tbx18+
Wt1tm1Jae/Wt1tm1Jae
involves: 129S4/SvJae MGI:3841149
cn57
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Pms2tm2(cre)Lisk/Pms2tm2(cre)Lisk
involves: 129S4/SvJae * 129S4/SvJaeSor MGI:5543250
cn58
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Resttm1.1Yasu/Resttm1.1Yasu
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA/J MGI:6241534
cn59
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Msx2tm1Rilm/Msx2tm1Rilm
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJae * C57BL/6J * CBA/J MGI:5427701
cn60
Gt(ROSA)26Sortm1Sor/?
Tg(GH1-cre)1Sac/?
involves: 129S4/SvJae * C57BL/6 * SJL MGI:3833235
cn61
Gt(ROSA)26Sortm1Sor/?
Tg(Mylpf-cre)3Kraj/0
involves: 129S4/SvJae * FVB/N MGI:3762370
cn62
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S4/SvJaeSor MGI:3806653
cn63
Gt(ROSA)26Sortm1Sor/?
Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
involves: 129S4/SvJaeSor MGI:3702510
cn64
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Pms2tm2(cre)Lisk/Pms2tm2(cre)Lisk
involves: 129S4/SvJaeSor MGI:5543251
cn65
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Wt1tm2(cre/ERT2)Wtp/Wt1+
involves: 129S4/SvJaeSor MGI:3802698
cn66
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Prdm1tm3(icre)Rob/Prdm1+
involves: 129S4/SvJaeSor MGI:5439604
cn67
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Mef2ctm1Eno/Mef2ctm1Jjs
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * CBA/J MGI:6209743
cn68
Dvl3tm1Awb/Dvl3tm1Awb
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm1(cre)Sev/Isl1+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * Black Swiss MGI:3831923
cn69
Nap1l2tm2.1Ucr/Y
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 MGI:5571359
cn70
Nap1l2tm2.1Ucr/Nap1l2tm2.1Ucr
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 MGI:5571358
cn71
Gt(ROSA)26Sortm1Sor/?
Myctm2Fwa/Myctm2Fwa
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA MGI:3720325
cn72
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Id3tm2.1Zhu/Id3tm2.1Zhu
Tg(Lck-cre)#Zhu/0
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL MGI:5009806
cn73
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tbx1tm3.1Bld/Tbx1tm6(cre)Bld
involves: 129S4/SvJaeSor * 129S7/SvEvBrd MGI:4453458
cn74
Hand2tm1Dsr/Hand2tm2.1Dsr
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm1(cre)Tmj/Isl1+
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6 MGI:4940091
cn75
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA MGI:5524048
cn76
Gt(ROSA)26Sortm1Sor/?
Wnt7btm2Amc/Wnt7btm2.1Amc
Tg(Hoxb7-cre)13Amc/0
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 MGI:3829882
cn77
Smotm2Amc/Smotm2.1Amc
H2az2Tg(Wnt1-cre)11Rth/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J MGI:4843924
cn78
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Tg(NPHS2-rtTA2*M2)1Jbk/Tg(NPHS2-rtTA2*M2)1Jbk
Tg(tetO-cre)LC1Bjd/0
involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/N MGI:6402038
cn79
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Tg(NPHS2-rtTA2*M2)1Jbk/Tg(NPHS2-rtTA2*M2)1Jbk
Tg(tetO-cre)LC1Bjd/Tg(tetO-cre)LC1Bjd
involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/N MGI:6402037
cn80
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Cck-cre)CKres/0
involves: 129S4/SvJaeSor * C57BL/6 MGI:4438372
cn81
ApcMin/Apc+
Dclk1tm1.1(cre/ERT2)Seno/Dclk1+
Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S4/SvJaeSor * C57BL/6 MGI:5475206
cn82
Lgr5tm1(cre/ERT2)Fjs/Lgr5tm2(DTR/EGFP)Fjs
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N MGI:5298069
cn83
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Nphs1-cre)33Mska/0
Tg(Nphs1-IL2RA)18Mska/0
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * DBA/2 MGI:3762559
cn84
Emx2tm2(cre)Sia/Emx2+
Gt(ROSA)26Sortm1Sor/?
involves: 129S4/SvJaeSor * C57BL/6 * CBA MGI:3716382
cn85
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Sftpc-cre)1Blh/0
involves: 129S4/SvJaeSor * C57BL/6 * DBA/2 MGI:5052295
cn86
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Recktm2.2Noda/Recktm3.1(cre/ERT2)Noda
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:5428661
cn87
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Tg(Slc26a5-cre)#Jnz/0
involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ MGI:5662258
cn88
Arid1atm1.1Mag/Arid1atm1.1Mag
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:5784731
cn89
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Pax3Sp-d/Pax3Sp-d
Tg(Prrx1-cre)1Cjt/0
involves: 129S4/SvJaeSor * C57BL/6J * SJL/J MGI:5775443
cn90
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Tex101-icre)2Lzj/0
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:4888572
cn91
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Ggt1-cre)M3Egn/?
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:3811271
cn92
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Myogtm1.1(cre/ERT2)Lepr/Myog+
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:5620019
cn93
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Myf6tm1.1(cre/ERT2)Lepr/Myf6+
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:5620018
cn94
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Myl1tm1.1(cre/ERT2)Lepr/Myl1+
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:5620017
cn95
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Myod1tm1.1(cre/ERT2)Lepr/Myod1+
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:5620016
cn96
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Pax3tm1.1(cre/ERT2)Lepr/Pax3+
involves: 129S4/SvJaeSor * C57BL/6 * SJL MGI:5620015
cn97
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tbx5tm1.2Jse/Tbx5tm1.2Jse
Tg(Kcne1-cre/ERT2)1Imos/0
involves: 129S4/SvJaeSor * CD-1 MGI:5474054
cn98
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Tg(PODXL-rtTA*M2)#Mjmr/Tg(PODXL-rtTA*M2)#Mjmr
Tg(tetO-cre)LC1Bjd/Tg(tetO-cre)LC1Bjd
involves: 129S/Sv * 129S4/SvJaeSor * BALB/c * C57BL/6J MGI:6402035
cn99
Dnmt3atm1Jae/Dnmt3atm1Jae
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Tg(Ins2-cre)23Herr/0
involves: 129S/Sv * Black Swiss * C57BL/6 * CBA/J * SJL MGI:5297821
cn100
Dvl3tm1Awb/Dvl3tm1Awb
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129S/Sv * Black Swiss * C57BL/6J * CBA/J MGI:3831922
cn101
Eomestm1Rob/Eomestm1.1Rob
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA MGI:3775735
cn102
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Ndufs4tm1Rpa/Ndufs4tm1Rpa
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 MGI:4818647
cn103
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm3Jpmb
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:3822876
cn104
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm2Jpmb
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:3822877
cn105
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1+
involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:3822878
cn106
Bhlhe22tm3.1(cre)Meg/Bhlhe22tm1Meg
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
involves: 129/Sv * 129S4/SvJaeSor MGI:4440937
cn107
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Thy1-cre/ERT2,-EYFP)AGfng/0
involves: C57BL/6 * SJL MGI:3719919
cn108
Foxa2tm1.1(rtTa)Moon/Foxa2tm1.1(rtTa)Moon
Gt(ROSA)26Sortm1Sor/?
Tg(tetO-cre)1Jaw/?
involves: C57BL/6 * SJL MGI:3713390
cn109
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Thy1-cre/ERT2,-EYFP)VGfng/0
involves: C57BL/6 * SJL MGI:3719920
cx110
Scxtm1Eno/Scxtm1Eno
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * Swiss) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6) MGI:3531461
cx111
Gt(ROSA)26Sortm1Sor/0
H2az2Tg(Wnt1-cre)11Rth/0
Pgap2clpex/Pgap2clpex
involves: 129S4/SvJaeSor * A/J * C57BL/6J * CBA/J MGI:6342276


Genotype
MGI:2176735
hm1
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:3803606
cn2
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm2(icre/ERT2)Jphe
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Gt(ROSA)26Sortm2(icre/ERT2)Jphe mutation (1 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• no abnormal phenotype is detected in the absence or presence of tamoxifen
• tamoxifen expression leads to beta-galactosidase expression in numerous tissues




Genotype
MGI:5085301
cn3
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Slc6a9tm1.1Caz/Slc6a9tm1.1Caz
Genetic
Background
B6.129P2-Slc6a9tm1.1Caz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Slc6a9tm1.1Caz mutation (0 available); any Slc6a9 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• homozygous mouse are viable but no phenotypic analysis was performed, however, following Ad5-CMV-Cre viral injection into the posterior and ventral thalamic area, binding of ligand to GlyT1 was significantly reduced in the area




Genotype
MGI:3852467
cn4
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Ptpn11tm1.1Rbns/Ptpn11tm1.1Rbns
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
B6.Cg-Ptpn11tm1.1Rbns Gt(ROSA)26Sortm1Sor H2az2Tg(Wnt1-cre)11Rth
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
Ptpn11tm1.1Rbns mutation (0 available); any Ptpn11 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• at E12.5, the number of neural crest cells in the outflow tract cushions are less than in wild-type mice
• at E17.5, the number of neural crest cells in the proximal outflow tract is less than in wild-type mice
• however, initial proliferation and migration are normal
• cranial neural crest cells fail to differentiate into osteoblasts unlike in wild-type mice

nervous system
• at E12.5, the number of neural crest cells in the outflow tract cushions are less than in wild-type mice
• at E17.5, the number of neural crest cells in the proximal outflow tract is less than in wild-type mice
• however, initial proliferation and migration are normal
• cranial neural crest cells fail to differentiate into osteoblasts unlike in wild-type mice

cardiovascular system
• at E12.5, the number of neural crest cells in the outflow tract cushions are less than in wild-type mice
• at E17.5, the number of neural crest cells in the proximal outflow tract is less than in wild-type mice
• however, initial proliferation and migration are normal




Genotype
MGI:5702903
cn5
Allelic
Composition
Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sortm1Sor
Tg(Mitf-cre)7114Gsb/0
Genetic
Background
C3FeJ.Cg-Gt(ROSA)26Sortm1(GNAQ*)Cvr/Gt(ROSA)26Sortm1Sor Tg(Mitf-cre)7114Gsb
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(GNAQ*)Cvr mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(Mitf-cre)7114Gsb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
pigmentation
• at 5 weeks of age, mice exhibit fewer lacZ+ cells in tail scales compared with control mice




Genotype
MGI:4839957
cn6
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm7(SMO*/YFP)Amc
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background
chimera involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Gt(ROSA)26Sortm7(SMO*/YFP)Amc mutation (0 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(CAG-cre/Esr1*)5Amc mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• dorsal CNS hyperproliferation at E13.5 after being exposed at E8.5 to tamoxifen

limbs/digits/tail
• observed at E13.5 after being exposed at E8.5 to tamoxifen




Genotype
MGI:3807487
cn7
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Ptf1atm1(cre)Cvw/Ptf1atm2Macd
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Ptf1atm1(cre)Cvw mutation (0 available); any Ptf1a mutation (18 available)
Ptf1atm2Macd mutation (0 available); any Ptf1a mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• the ventral pancreas fails to form at E11.5 with the precursor cells reverting to an intestinal epithelial fate
• growth retardation of the dorsal epithelial bud is evident at E11.5
• the dorsal epithelial bud is significantly smaller at E12.5
• at E17.5, the dorsal pancreatic epithelium is a truncated, poorly branched, duct like structure without islet or acinar tissues




Genotype
MGI:5563244
cn8
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Rb1tm2Brn mutation (3 available); any Rb1 mutation (78 available)
Trp53tm1Brn mutation (14 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice injected with an adenovirus expressing cre (adeno-cre) into the lateral ventricle predominantly develop poorly differentiated, well-circumscribed neoplasms with similarity to supratentorial primitive neuroectodermal tumors (sPNET)
• expression profiles of tumors resemble human atypical teratoid/rhabdoid tumor

neoplasm
• mice injected with an adenovirus expressing cre (adeno-cre) into the lateral ventricle predominantly develop poorly differentiated, well-circumscribed neoplasms with similarity to supratentorial primitive neuroectodermal tumors (sPNET)
• expression profiles of tumors resemble human atypical teratoid/rhabdoid tumor




Genotype
MGI:5563247
cn9
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptentm1Mro/Ptentm1Mro
Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Ptentm1Mro mutation (1 available); any Pten mutation (39 available)
Rb1tm2Brn mutation (3 available); any Rb1 mutation (78 available)
Trp53tm1Brn mutation (14 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice injected with an adenovirus expressing cre (adeno-cre) into the lateral ventricle predominantly develop poorly differentiated, well-circumscribed neoplasms with similarity to supratentorial primitive neuroectodermal tumors (sPNET)
• expression profiles of tumors resemble human atypical teratoid/rhabdoid tumor

neoplasm
• mice injected with an adenovirus expressing cre (adeno-cre) into the lateral ventricle predominantly develop poorly differentiated, well-circumscribed neoplasms with similarity to supratentorial primitive neuroectodermal tumors (sPNET)
• expression profiles of tumors resemble human atypical teratoid/rhabdoid tumor




Genotype
MGI:3836424
cn10
Allelic
Composition
Aurkatm1.1Tvd/Aurkatm1.1Tvd
Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sortm1Sor
Genetic
Background
involves: 129 * 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aurkatm1.1Tvd mutation (1 available); any Aurka mutation (18 available)
Gt(ROSA)26Sortm1(cre/ERT)Nat mutation (2 available); any Gt(ROSA)26Sor mutation (540 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in MEFs at later time points after OHT treatment and serum addition cells develop large aberrant nuclei with frequent micronuclei
• in MEFS after OHT treatment and serum addition increases in the population of cells with 4N and 8N DNA content are seen
• live cell imaging indicates a median 8 h delay in mitotic entry in MEFS after OHT treatment and serum addition compared to controls
• in MEFS after OHT treatment and serum addition more cells are in prophase and most of these show an early prophase phenotype
• in MEFS after OHT treatment and serum addition almost no cells in metaphase, anaphase, and telophase are detected
• in MEFS after OHT treatment and serum addition cells in prometaphase have a monopolar spindle with closely adjacent chromosomes, the presence of these monopolar spindles activates the spindle checkpoint
• in MEFS 28 h after OHT treatment and serum addition the percent of cells positive for PH3 is increased about 3 fold compared to controls
• however, the timing of the peak in PH3 positive cells is similar to controls
• growth defect in MEFs following OHT treatment and serum addition




Genotype
MGI:3767612
cn11
Allelic
Composition
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Tie1-cre)9Ref/?
Gt(ROSA)26Sortm1Sor/?
Genetic
Background
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tgfbr2tm1Karl mutation (1 available); any Tgfbr2 mutation (7 available)
Tg(Tie1-cre)9Ref mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are present at E9.5 but dead by E12.5

embryo
• mice lack networks of vessels at all stages
• at E9.5, mice appear delayed by 1 day

growth/size/body
• at E9.5, mice appear delayed by 1 day

craniofacial

cardiovascular system
• mice lack networks of vessels at all stages
• at E9.5, hearts exhibit pericardial effusion

homeostasis/metabolism
• at E9.5, hearts exhibit pericardial effusion




Genotype
MGI:3767613
cn12
Allelic
Composition
Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
Tg(Tie1-cre)9Ref/?
Gt(ROSA)26Sortm1Sor/?
Genetic
Background
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tgfbr1tm1.1Karl mutation (1 available); any Tgfbr1 mutation (8 available)
Tg(Tie1-cre)9Ref mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are present at E9.5 but dead by E12.5

embryo
• mice lack networks of vessels at all stages
• at E9.5, mice appear delayed by 1 day
• yolk sacs possess greater numbers of vascular smooth muscle cells than in wild-type yolk sacs

growth/size/body
• at E9.5, mice appear delayed by 1 day

cardiovascular system
• mice lack networks of vessels at all stages
• at E9.5, hearts exhibit pericardial effusion

homeostasis/metabolism
• at E9.5, hearts exhibit pericardial effusion




Genotype
MGI:4940095
cn13
Allelic
Composition
Hand2tm1Dsr/Hand2tm2.1Dsr
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Tbx1-cre)#Dsr/0
Genetic
Background
involves: 129 * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Hand2tm1Dsr mutation (0 available); any Hand2 mutation (1 available)
Hand2tm2.1Dsr mutation (0 available); any Hand2 mutation (1 available)
Tg(Tbx1-cre)#Dsr mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E12.5, mice exhibit narrowed outflow tract and hypoplastic outlet or subpulmonary conus compared with wild-type mice
• at E14.5, the right ventricular cavity is smaller than in wild-type mice
• however, the right ventricular muscle wall thickness is normal




Genotype
MGI:3716982
cn14
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm1(cre/Esr1*)Krc/Isl1+
Genetic
Background
involves: 129 * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Isl1tm1(cre/Esr1*)Krc mutation (1 available); any Isl1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• used for expression analysis only




Genotype
MGI:5563246
cn15
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptentm1Mro/Ptentm1Mro
Rb1tm2Brn/Rb1tm2Brn
Genetic
Background
involves: 129 * 129S4/SvJaeSor * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Ptentm1Mro mutation (1 available); any Pten mutation (39 available)
Rb1tm2Brn mutation (3 available); any Rb1 mutation (78 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice injected with an adenovirus expressing cre (adeno-cre) into the lateral ventricle do not develop tumors after up to 440 days




Genotype
MGI:5447167
cn16
Allelic
Composition
Jag1tm1Frad/Jag1tm1Frad
Tg(Cdh5-cre)7Mlia/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129 * 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Jag1tm1Frad mutation (0 available); any Jag1 mutation (8 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E10.5, atrioventricular cushions exhibit rounded endocardial-derived cells that accumulate at the cushion interface and less dense, hypoplastic areas unlike in control mice




Genotype
MGI:5447168
cn17
Allelic
Composition
Notch1tm1Agt/Notch1tm1Agt
Tg(Cdh5-cre)7Mlia/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129 * 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Notch1tm1Agt mutation (0 available); any Notch1 mutation (32 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E10.5, atrioventricular cushions exhibit rounded endocardial-derived cells that accumulate at the cushion interface and less dense, hypoplastic areas unlike in control mice




Genotype
MGI:5304570
cn18
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Pdss2tm1.1Jdhu/Pdss2tm1.2Jdhu
Tg(Pcp2-cre)3555Jdhu/0
Genetic
Background
involves: 129 * C3H/HeNCr MMTV- * C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Pdss2tm1.1Jdhu mutation (0 available); any Pdss2 mutation (24 available)
Pdss2tm1.2Jdhu mutation (0 available); any Pdss2 mutation (24 available)
Tg(Pcp2-cre)3555Jdhu mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• at 9.5 months, mice exhibit failure in motor coordination during walking and incapability to maintain balance on a rod
• gradual
• mice exhibit shorter and more variable strides with more frequent additional steps made by both forepaw and hindpaw compared with wild-type mice
• and more variable

nervous system
• at 6 months in the cerebellum
• in the cerebellum of aged mice
• at 6 months in the cerebellum

cellular
• at 6 months in the cerebellum




Genotype
MGI:5285375
cn19
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Sox11tm2.1Weg/Sox11tm2.1Weg
Sox4tm1Vlf/Sox4tm1Vlf
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
Sox11tm2.1Weg mutation (0 available); any Sox11 mutation (1 available)
Sox4tm1Vlf mutation (0 available); any Sox4 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• massive cell death in the branchial arches without a decrease in cell proliferation




Genotype
MGI:5308956
cn20
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm3Kba
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (23 available)
Ctnnb1tm3Kba mutation (0 available); any Ctnnb1 mutation (23 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• not developed at E10.5

craniofacial
• hypoplastic and malformed

skeleton
• hypoplastic and malformed




Genotype
MGI:5308958
cn21
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129 * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (23 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• at E12.5
• at E12.5
• rudimentary at E12.5

nervous system
• absence of midbrain structures at E10.5
• absence of hindbrain structures at E10.5

embryo
• rudimentary at E12.5

skeleton
• at E12.5
• at E12.5




Genotype
MGI:4822000
cn22
Allelic
Composition
Cdh1tm1.1Mpst/Cdh1tm2Kem
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Vil1-cre)20Syr/0
Genetic
Background
involves: 129 * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdh1tm1.1Mpst mutation (0 available); any Cdh1 mutation (120 available)
Cdh1tm2Kem mutation (1 available); any Cdh1 mutation (120 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(Vil1-cre)20Syr mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5911951
cn23
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Meis2tm1.1Zkoz/Meis2tm1.1Zkoz
Tfap2atm1(cre)Moon/Tfap2a+
Genetic
Background
involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Meis2tm1.1Zkoz mutation (0 available); any Meis2 mutation (4 available)
Tfap2atm1(cre)Moon mutation (1 available); any Tfap2a mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die around the time of birth

cardiovascular system
• poor colonization of the outflow tract by cardiac neural crest cells at E10.5
• poor colonization of the outflow tract by cardiac neural crest cells at E10.5
• at E11 the outflow tract has a lower density of cardiac neural crest cells and these cells are disorganized
• however, septation occurs normally
• in some embryos
• malformed outflow tract valves in 90% of mice at E12

nervous system
• poor colonization of the outflow tract by cardiac neural crest cells at E10.5
• smaller and misshapen
• less affected compared to germline null mice

vision/eye
• fail to grow and close over the eye bulb at E17

skeleton
• boundary of ossification is abnormal
• severely malformed
• poorly developed
• severely malformed palatal cartilage in 33% of mice with less severe malformations in the remaining 67% of mice
• otic capsule cartilage is absent at E16 in 33% of mice and reduced in 66% of mice

hearing/vestibular/ear
• cartilage is absent at E16 in 33% of mice and reduced in 66% of mice

craniofacial
• boundary of ossification is abnormal
• severely malformed
• poorly developed
• severely malformed cartilage in 33% of mice with less severe malformations in the remaining 67% of mice
• small with disorganized muscle fibers at E14

digestive/alimentary system
• severely malformed cartilage in 33% of mice with less severe malformations in the remaining 67% of mice
• small with disorganized muscle fibers at E14

growth/size/body
• severely malformed cartilage in 33% of mice with less severe malformations in the remaining 67% of mice
• small with disorganized muscle fibers at E14

embryo
• poor colonization of the outflow tract by cardiac neural crest cells at E10.5




Genotype
MGI:4353176
cn24
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Pax7tm1.1Fan/Pax7tm2.1(cre/ERT2)Fan
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Pax7tm1.1Fan mutation (1 available); any Pax7 mutation (33 available)
Pax7tm2.1(cre/ERT2)Fan mutation (1 available); any Pax7 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
N
• following tamoxifen-treatment, injury-induced myogenesis and satellite cell characteristics are normal
• in culture, tamoxifen-treated P0 myoblasts exhibit defective expansive and myogenic potentials compared with control Pax7tm2.1(cre/ERT2)Fan heterozygous myoblasts
• however, myoblasts from tamoxifen-treated adults exhibit normal expansive and myogenic potentials
• following tamoxifen treatment between P7 and P11, regeneration is severely compromised compared to in control Pax7tm2.1(cre/ERT2)Fan heterozygotes
• however, following tamoxifen treatment between P14 to P18 and P21 to P25 regeneration capacity gradually increased to levels in control Pax7tm2.1(cre/ERT2)Fan heterozygotes
• following tamoxifen treatment, myofibers continue to be incorporated into a regenerating muscle beyond P31 longer than in control Pax7tm2.1(cre/ERT2)Fan heterozygotes




Genotype
MGI:3767614
cn25
Allelic
Composition
Tgfbr2tm1Karl/Tgfbr2tm1Karl
Tg(Tagln-cre)1Her/?
Gt(ROSA)26Sortm1Sor/?
Genetic
Background
involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tgfbr2tm1Karl mutation (1 available); any Tgfbr2 mutation (7 available)
Tg(Tagln-cre)1Her mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between E12.5 and E16.5; only resorbed homozygous embryos are recovered at E16.5

embryo
• while yolk sacs are normal at E9.5 by E12.5 yolk sacs are pale, anemic and possess obvious vasculature defects
• at E12.5, yolk sacs are pale and anemic

growth/size/body

cardiovascular system
• while yolk sacs are normal at E9.5 by E12.5 yolk sacs are pale, anemic and possess obvious vasculature defects
• mice exhibit delayed underdeveloped hearts

nervous system
• mice exhibit delayed underdeveloped brains




Genotype
MGI:4418525
cn26
Allelic
Composition
Hif1atm3Rsjo/Hif1atm3Rsjo
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hprttm1(Pck1-cre)Vhh/Y
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Hif1atm3Rsjo mutation (3 available); any Hif1a mutation (11 available)
Hprttm1(Pck1-cre)Vhh mutation (0 available); any Hprt mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice
• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice

cellular
• hypoxic primary tubular epithelial cells fails to undergo an epithelial to mesenchyme transition unlike similarly treated cells from Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice

homeostasis/metabolism
• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice

immune system
• after ureteral ligation, mice exhibit reduced fibrosis and inflammation compared with similarly treated Hif1atm3Rsjo/Hif1atm3Rsjo Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ mice




Genotype
MGI:5790976
cn27
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptentm1Mro/Ptentm1Mro
Slc1a3tm1(cre/ERT2)Mgoe/Slc1a3+
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Ptentm1Mro mutation (1 available); any Pten mutation (39 available)
Slc1a3tm1(cre/ERT2)Mgoe mutation (0 available); any Slc1a3 mutation (23 available)
Trp53tm1Brn mutation (14 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• 3 of 16 mice injected with endoxifen develop glial tumors with lesions of different sizes and varying extents of infiltration
• small neoplastic lesions in endoxifen-induced mice arise from beneath the SVZ and extend into the striatum and dorsally into the corpus callosum
• larger tumors of endoxifen-induced mice show expansion into and a diffuse infiltration of the entire caudate nucleus
• some tumors contain areas of necrosis and occasional microvascular proliferations similar to those in malignant gliomas
• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas
• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas

nervous system
• 3 of 16 mice injected with endoxifen develop glial tumors with lesions of different sizes and varying extents of infiltration
• small neoplastic lesions in endoxifen-induced mice arise from beneath the SVZ and extend into the striatum and dorsally into the corpus callosum
• larger tumors of endoxifen-induced mice show expansion into and a diffuse infiltration of the entire caudate nucleus
• some tumors contain areas of necrosis and occasional microvascular proliferations similar to those in malignant gliomas
• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas
• endoxifen-induced tumors show glial morphology with features typical of astrocytomas and oligodendrogliomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
malignant glioma DOID:3070 OMIM:PS137800
J:229481




Genotype
MGI:3831282
cn28
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hprttm1(Pbsn*-cre/ERT2)Jir/Hprt+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Hprttm1(Pbsn*-cre/ERT2)Jir mutation (0 available); any Hprt mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5790977
cn29
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptentm1Mro/Ptentm1Mro
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Ptentm1Mro mutation (1 available); any Pten mutation (39 available)
Trp53tm1Brn mutation (14 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice injected with an adenovirus expressing cre recombinase (Ad-Cre) into the left ventricle exhibit a 33.3% incidence of glioma
• in left ventricle Ad-cre injected mice
• in left ventricle Ad-cre injected mice

nervous system
• mice injected with an adenovirus expressing cre recombinase (Ad-Cre) into the left ventricle exhibit a 33.3% incidence of glioma
• in left ventricle Ad-cre injected mice
• in left ventricle Ad-cre injected mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
malignant glioma DOID:3070 OMIM:PS137800
J:229481




Genotype
MGI:3818077
cn30
Allelic
Composition
Fgf8tm1.3Mrt/Fgf8tm1.4Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm1.3Mrt mutation (1 available); any Fgf8 mutation (11 available)
Fgf8tm1.4Mrt mutation (0 available); any Fgf8 mutation (11 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• anterior heart field (AHF) cells are lost compared to controls; numbers of B-gal +ve cells in splanchnic mesoderm (SM) and pharyngeal endoderm are significantly reduced, causing thinning of these cell layers
• number of positive cells in pharyngeal arch core mesoderm (CM) is significantly decreased also

embryo
• thinning of splanchnic mesoderm due to significantly reduced numbers of B-gal +ve cells




Genotype
MGI:6367573
cn31
Allelic
Composition
Gata6osem3Zfa/Gata6osem3Zfa
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6osem3Zfa mutation (0 available); any Gata6os mutation (0 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• reduced cycling and proliferation of intestinal stem cells
• however, proliferation rates are normal

digestive/alimentary system
• reduced cycling and proliferation of intestinal stem cells
• however, proliferation rates are normal




Genotype
MGI:6367570
cn32
Allelic
Composition
Gata6osem1Zfa/Gata6osem1Zfa
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata6osem1Zfa mutation (0 available); any Gata6os mutation (0 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• impaired intestinal epithelial renewal in tamoxifen treated mice




Genotype
MGI:5563238
cn33
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptentm1Mro/Ptentm1Mro
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Ptentm1Mro mutation (1 available); any Pten mutation (39 available)
Trp53tm1Brn mutation (14 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice injected with an adenovirus expressing cre (adeno-cre) into the lateral ventricle develop a spectrum of gliomas, including anaplastic astrocytomas, oligodendrogliomas, and most commonly, anaplastic oligoastrocytomas
• however, adeno-cre injected mice do not develop glioblastoma with palisading necrosis or microvascular proliferation
• tumors in adeno-cre injected mice resemble The Cancer Genome Atlas (TCGA) classical glioblastomas, Phillips proneural and TACG neural gliomas
• mice injected with an adeno-cre into the lateral ventricle develop anaplastic oligoastrocytoma
• oligoastrocytomas do not resemble any human gliobastoma subtypes
• mice injected with an adeno-cre into the lateral ventricle develop oligodendrogliomas

neoplasm
• mice injected with an adenovirus expressing cre (adeno-cre) into the lateral ventricle develop a spectrum of gliomas, including anaplastic astrocytomas, oligodendrogliomas, and most commonly, anaplastic oligoastrocytomas
• however, adeno-cre injected mice do not develop glioblastoma with palisading necrosis or microvascular proliferation
• tumors in adeno-cre injected mice resemble The Cancer Genome Atlas (TCGA) classical glioblastomas, Phillips proneural and TACG neural gliomas
• mice injected with an adeno-cre into the lateral ventricle develop anaplastic oligoastrocytoma
• oligoastrocytomas do not resemble any human gliobastoma subtypes
• mice injected with an adeno-cre into the lateral ventricle develop oligodendrogliomas




Genotype
MGI:4437229
cn34
Allelic
Composition
En1tm7(cre/ESR1)Alj/0
Fgf8tm1.3Mrt/Fgf8tm2.1Jyhl
Gt(ROSA)26Sortm1Sor/0
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm7(cre/ESR1)Alj mutation (1 available); any En1 mutation (23 available)
Fgf8tm1.3Mrt mutation (1 available); any Fgf8 mutation (11 available)
Fgf8tm2.1Jyhl mutation (0 available); any Fgf8 mutation (11 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• unlike mice homozygous for Fgf8tm2.1Jyhl, mice are normal in size

nervous system
N
• unlike mice homozygous for Fgf8tm2.1Jyhl, the size of the midbrain and cerebellum are normal




Genotype
MGI:3822771
cn35
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hesx1tm1(cre)Jpmb/Hesx1tm1Icar
Genetic
Background
involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Hesx1tm1(cre)Jpmb mutation (0 available); any Hesx1 mutation (9 available)
Hesx1tm1Icar mutation (0 available); any Hesx1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• telencepepahlic vesicle development is often asymmetric in embryos, with the right side being more severely affected
• very small telencephalic vesicle is sometimes observed at the 8-10 somite stage

vision/eye
• development of optic vesicles is often asymmetric with right side more severely affected




Genotype
MGI:3789333
cn36
Allelic
Composition
En1tm7(cre/ESR1)Alj/En1+
En2tm2Alj/En2tm2Alj
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm7(cre/ESR1)Alj mutation (1 available); any En1 mutation (23 available)
En2tm2Alj mutation (0 available); any En2 mutation (7 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• when tamoxifen is administered at E10.5, rhombomere 1 (r1) is reduced in size in mutants at E12.5
• anterior r1 cells contribute to more lateral regions of vermis than normal
• when tamoxifen is administered at E10.5, mesencephalon is reduced in size at E12.5 relative to normal
• marked cells in posterior mesencephalon do not expand normally
• when tamoxifen is administered at E10.5, size of marked domain is smaller than wild-type at E16.5
• in adults, marked domain in tectum is greatly reduced compared to wild-type; marked domain is restricted to remaining region of inferior colliculus
• when tamoxifen is administered at E10.5, size of marked cell population is wider in mutants than in controls at E16.5
• in adults, marked domain is broader than normal
• in adults, vermis is reduced in size

embryo
• when tamoxifen is administered at E10.5, rhombomere 1 (r1) is reduced in size in mutants at E12.5
• anterior r1 cells contribute to more lateral regions of vermis than normal




Genotype
MGI:6150944
cn37
Allelic
Composition
Daam1tm1.1Tpy/Daam1tm1.1Tpy
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Daam1tm1.1Tpy mutation (0 available); any Daam1 mutation (21 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Nkx2-5tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in E13.5 embryos
• cardiomyocytes smaller, rounded and loosely attached to each other with thin cellular projections in conotruncal regions
• absent thick protrusions from leading edges of cardiomyocytes invading non-myocardial tissue
• cardiomyocytes randomly distributed and mixed with endocardial cells at bases of blood vessels

muscle
• in E13.5 embryos
• cardiomyocytes smaller, rounded and loosely attached to each other with thin cellular projections in conotruncal regions
• absent thick protrusions from leading edges of cardiomyocytes invading non-myocardial tissue
• cardiomyocytes randomly distributed and mixed with endocardial cells at bases of blood vessels




Genotype
MGI:4441394
cn38
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nr2f2tm2.1Tsa/Nr2f2tm2.1Tsa
Prox1tm3(cre/ERT2)Gco/Prox1+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Nr2f2tm2.1Tsa mutation (0 available); any Nr2f2 mutation (3 available)
Prox1tm3(cre/ERT2)Gco mutation (1 available); any Prox1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• embryos exposed to tamoxifen at E10.5-12.5 show some blood-filled dermal lymphatic vessels
• embryos exposed to tamoxifen show reduced number of superficial vessels (X-gal stained); severity of reduction increases with early tamoxifen treatment
• tamoxifen treatment at E10.5 or E11.5 results in severely reduced lymphatic endothelial cell numbers and lack of lymphatic vessels
• embryos exposed to tamoxifen at E10.5 or 11.5 display drastically mispatterned lymph sacs that are reduced in size compared to controls
• when tamoxifen exposure occurs at E13.5, few embryos show any lymphatic defects, while exposure later in development or postnatally causes no obvious defects despite reduction in Nr2f2 expression in LECs

homeostasis/metabolism
• embryos exposed to tamoxifen at E10.5-12.5 (analyzed at E15.5) display edema




Genotype
MGI:3695168
cn39
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Ptf1atm1.1(cre)Cvw/Ptf1atm1.1(cre)Cvw
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Ptf1atm1.1(cre)Cvw mutation (1 available); any Ptf1a mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• precursors normally fated to become amacrine and horizontal cells switch to ganglion cell fates, resulting in an increase in ganglion cells

nervous system
• precursors normally fated to become amacrine and horizontal cells switch to ganglion cell fates, resulting in an increase in ganglion cells

digestive/alimentary system
• exhibit a switch of pancreatic progenitors such that their progeny proliferate in and adopt the normal fates of duodenal epithelium, including its stem-cell compartment
• at E10.5, E12.5, E14.5, E16.5, and E18.5, exocrine acini are completely absent

endocrine/exocrine glands
• at E10.5, E12.5, E14.5, E16.5, and E18.5, exocrine acini are completely absent
• conversion of pancreatic precursors into duodenal fates; form rudimentary pancreatic tissue that contains ductal and endocrine cell types




Genotype
MGI:5471122
cn40
Allelic
Composition
Kdrtm1Wag/Kdrtm1Wag
Nfatc1tm1.1(cre)Bz/Nfatc1+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Kdrtm1Wag mutation (0 available); any Kdr mutation (12 available)
Nfatc1tm1.1(cre)Bz mutation (0 available); any Nfatc1 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• embryos do not develop intramyocardial coronary arteries
• at E11.5, endocardial cells cannot respond to Vegf120 and fail to migrate, sprout, and form endothelial networks




Genotype
MGI:5447985
cn41
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
HhatTg(TFAP2A-cre)1Will/HhatTg(TFAP2A-cre)1Will
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
HhatTg(TFAP2A-cre)1Will mutation (1 available); any Hhat mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• hypoplastic, particularly the trigeminal ganglion
• maxillary branch is consistently narrower than in controls




Genotype
MGI:3851799
cn42
Allelic
Composition
Fgf10tm1Ska/Fgf10tm1Sms
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Twist2tm1(cre)Dor/Twist2+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf10tm1Ska mutation (0 available); any Fgf10 mutation (10 available)
Fgf10tm1Sms mutation (0 available); any Fgf10 mutation (10 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Twist2tm1(cre)Dor mutation (0 available); any Twist2 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• E17.5 embryos often have hemorrhaging in the lung
• at E12, moderate increases in apoptosis are observed in the primary bronchi of both lungs
• cell death extended farther into the medial and accessory branches and there was a small area of ectopic death observed in the mesenchyme of either the vestigial rostral lobe or at the distal tip of the accessory lobe
• all lobes exhibit reduced branching following outgrowth of the initial branch that established the lobe
• mesenchymal protrusions without an accompanying epithelial branch are occasionally observed during embryonic development
• such protrusions are observed only in the right lung in positions that correspond to lobes
• at E17.5, mutant lobes are smaller and much flatter than control lobes
• at E12.5, the accessory lobe is reduced in size and often misshapen
• most E11.5 embryos have a reduction or absence of the nascent rostral lobe
• at E12.5, the rostral lobe is absent in the majority of mice
• at E12.5, the medial lobe is reduced in size and often misshapen
• at E17.5, mutant lobes are smaller than control lobes
• at E12.5, mutant lungs are smaller than control lungs
• at E17.5, mutant lungs are severely hypoplastic

cardiovascular system
• E17.5 embryos often have hemorrhaging in the lung




Genotype
MGI:5298219
cn43
Allelic
Composition
Pitx2tm1.1Sac/Pitx2tm2Sac
H2az2Tg(Wnt1-cre)11Rth/?
Gt(ROSA)26Sortm1Sor/?
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
Pitx2tm1.1Sac mutation (1 available); any Pitx2 mutation (11 available)
Pitx2tm2Sac mutation (0 available); any Pitx2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• devoid of pigment except for a cone shaped region in the anterior segment
• retinal pigment layer is normal at E10.5 but pigment loss begins at E12.5
• corneal stroma and epithelium are absent
• hypomorphic hyaloid blood vessels
• muscle bundles present adjacent to the anterior segment
• eye stalk fails to extend at E12.5
• eyes directly attached to ventral diencephalon by E14.5
• retinal ganglion cell axons enter ventral thalamus and form an optic chiasma-like structure
• eyes are not visible externally at E16.5
• eyes present but buried within the skull near the midline directly beneath the brain
• lens and retina present

pigmentation
• devoid of pigment except for a cone shaped region in the anterior segment
• retinal pigment layer is normal at E10.5 but pigment loss begins at E12.5

nervous system

muscle
• muscle bundles present adjacent to the anterior segment




Genotype
MGI:3639491
cn44
Allelic
Composition
Fgf15tm1Sms/Fgf15tm1Sms
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf15tm1Sms mutation (1 available); any Fgf15 mutation (10 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• at E12.5, homozygotes exhibit successful septation of the distal outflow tract; however, the number of NCCs contributing to the proximal outflow tract is significantly reduced
• at E9.5, cardiac NCCs migrate to the developing caudal pharyngeal arches of mutant embryos in numbers comparable to those of wild-type embryos; however, at E11.5, NCCs fail to invaginate on the right side of the proximal aortic sac at the level of its connection with the 6th aortic arch arteries
• as a result, the conotruncal cushions remain oriented laterally relative to one another

cardiovascular system
• at E12.5, homozygotes exhibit successful septation of the distal outflow tract; however, the number of NCCs contributing to the proximal outflow tract is significantly reduced
• homozygotes exhibit abnormal NCC behavior during outflow tract remodeling

nervous system
• at E12.5, homozygotes exhibit successful septation of the distal outflow tract; however, the number of NCCs contributing to the proximal outflow tract is significantly reduced

cellular
• at E9.5, cardiac NCCs migrate to the developing caudal pharyngeal arches of mutant embryos in numbers comparable to those of wild-type embryos; however, at E11.5, NCCs fail to invaginate on the right side of the proximal aortic sac at the level of its connection with the 6th aortic arch arteries
• as a result, the conotruncal cushions remain oriented laterally relative to one another




Genotype
MGI:3701116
cn45
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Hsd11b2tm1(cre)Anft/Hsd11b2+
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Hsd11b2tm1(cre)Anft mutation (0 available); any Hsd11b2 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice express cre in all mineralcorticoid target tissues, as determined by reporter expression




Genotype
MGI:5314779
cn46
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Srctm1Mul/Srctm1Mul
Tg(MMTV-cre)7Mul/0
Tg(MMTV-PyVT)#Mul/0
Genetic
Background
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Srctm1Mul mutation (0 available); any Src mutation (121 available)
Tg(MMTV-cre)7Mul mutation (0 available)
Tg(MMTV-PyVT)#Mul mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice exhibit the same incidence of lung metastases and average metastatic burden as in Tg(MMTV-PyVT)#Mul mice




Genotype
MGI:3817490
cn47
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm2Sev/Isl1tm2Sev
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
Isl1tm2Sev mutation (1 available); any Isl1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die within a few hours of birth

nervous system
• cutaneous branch of the ventral ramus is absent in E14.5 embryos
• innervation of the distal limbs at E14.5 confirmed a nearly complete loss of fine cutaneous sensory fibers with only a single sensory branch innervating one side of digits 1, 2 and 5 in both the forelimb and hindlimb
• there is an increased rate of apoptosis within the trigeminal ganglia of E11.5 and E12.5 embryos
• the dorsal root ganglion (DRG) of E12.5 embryos do not express Isl1 protein
• TrkA+ neurons are lower in number starting at E12.5 and by E14.5 are less than one-third of what is found in controls
• TrkB+ neurons are also lower in number starting at E12.5 and are markedly reduced at E14.5 and birth
• TrkC+ neurons do not appear until E12.5, a delay of two days compared to controls
• the DRG of E14.5 embryos is markedly smaller than controls with a smaller number neurons found within the ganglion
• an increased rate of apoptosis is noted in the E12.5 DRG

behavior/neurological
• mice have a reduced response to a mild noxious stimulus that was applied to the skin of the trunk or limbs

integument
• mice have a reduced response to a mild noxious stimulus that was applied to the skin of the trunk or limbs




Genotype
MGI:3840452
cn48
Allelic
Composition
Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gbx2tm1.1(cre/ERT2)Jyhl mutation (1 available); any Gbx2 mutation (5 available)
Gbx2tm1Mrt mutation (0 available); any Gbx2 mutation (5 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• following tamoxifen treatment mild defects in thalamus morphology are seen in some mutants with high levels of recombination but for the most part defects in establishment of dorsal and posterior thalamic boundaries seen in null mice are not seen
• this result and chimera experiments suggest that the function of Gbx2 is cell nonautonomous




Genotype
MGI:3840450
cn49
Allelic
Composition
Gbx2tm1.1(cre/ERT2)Jyhl/Gbx2tm1.1Mrt
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gbx2tm1.1(cre/ERT2)Jyhl mutation (1 available); any Gbx2 mutation (5 available)
Gbx2tm1.1Mrt mutation (0 available); any Gbx2 mutation (5 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• at E14.5, cells expressing lacZ are found across the dorsal and posterior borders of the thalamus expanding into the epithalamus and pretectum
• ectopic lacZ expressing cells from the thalamus are mainly found in the lateral habenular nuclei and anterior part of the pretectum at E18.5
• at E10.5 the thalamus is smaller in the mediolateral dimension and larger in the ventrodorsal dimension
• thalamus morphology is severely disrupted after E14.5




Genotype
MGI:3841148
cn50
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tbx18tm4(cre)Akis/Tbx18+
Genetic
Background
involves: 129S1/SvImJ * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tbx18tm4(cre)Akis mutation (0 available); any Tbx18 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• mice were used for expression analysis only




Genotype
MGI:3762357
cn51
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Evx2/Hoxd13tm4(cre)Ddu/Hoxd13+
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Evx2/Hoxd13tm4(cre)Ddu mutation (0 available); any Hoxd13 mutation (11 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• only expression of Cre from Evx2/Hoxd13tm4Ddu allele by LacZ labeling is analyzed




Genotype
MGI:3762355
cn52
Allelic
Composition
Del(2Hoxd4-Hoxd13)28Ddu/+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd4-Hoxd13)28Ddu mutation (1 available); any Del(2Hoxd4-Hoxd13)28Ddu mutation (1 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• only expression of Cre from Del(2Hoxd4-Hoxd13)28Ddu allele by LacZ labeling is analyzed




Genotype
MGI:3762353
cn53
Allelic
Composition
Del(2Hoxd11-Hoxd13)27Ddu/+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)27Ddu mutation (1 available); any Del(2Hoxd11-Hoxd13)27Ddu mutation (1 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• only expression of Cre from Del(2Hoxd11-Hoxd13)27Ddu allele by LacZ labeling is analyzed




Genotype
MGI:3762358
cn54
Allelic
Composition
Evx2/Hoxd13tm4(cre)Ddu/Evx2+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Evx2/Hoxd13tm4(cre)Ddu mutation (1 available); any Evx2 mutation (16 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• only expression of Cre from Evx2/Hoxd13tm4Ddu allele by LacZ labeling is analyzed




Genotype
MGI:3830091
cn55
Allelic
Composition
Ntrk2tm2Kln/Ntrk2tm2Kln
Slc1a3tm1(cre/ERT2)Mgoe/?
Gt(ROSA)26Sortm1Sor/?
Genetic
Background
involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Ntrk2tm2Kln mutation (0 available); any Ntrk2 mutation (15 available)
Slc1a3tm1(cre/ERT2)Mgoe mutation (0 available); any Slc1a3 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• fewer neurons arising in hippocampus from radial glial cells after treatment with tamoxifen survive to become mature neurons
• axon elongation is unaffected
• dendritic branching and lengths are reduced in neurons arising in the hippocampus from radial glial cells after treatment with tamoxifen
• reduced dendritic complexity 90 um from soma
• spine density is significantly reduced
• lasts only 30-40 minutes as compared to over 90 minutes for controls

behavior/neurological
• studied between 28 and 42 days after tamoxifen treatment
• enter the center in an open field test less frequently and spend less time there
• more time spent on the periphery in an open field test
• in an elevated + maze, fewer entries into the open arms and less time spent in the open arms
• studied between 28 and 42 days after tamoxifen treatment
• less spontaneous activity in an open field test

cellular
• fewer neurons arising in hippocampus from radial glial cells after treatment with tamoxifen survive to become mature neurons
• axon elongation is unaffected




Genotype
MGI:3841149
cn56
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tbx18tm4(cre)Akis/Tbx18+
Wt1tm1Jae/Wt1tm1Jae
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tbx18tm4(cre)Akis mutation (0 available); any Tbx18 mutation (19 available)
Wt1tm1Jae mutation (3 available); any Wt1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• the formation of the epicardium is severely compromised in E12.5 embryos




Genotype
MGI:5543250
cn57
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Krastm4Tyj/Kras+
Pms2tm2(cre)Lisk/Pms2tm2(cre)Lisk
Genetic
Background
involves: 129S4/SvJae * 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Krastm4Tyj mutation (8 available); any Kras mutation (37 available)
Pms2tm2(cre)Lisk mutation (0 available); any Pms2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• animals become moribund at 5 weeks of age due to high lung tumor burden

homeostasis/metabolism
• numbers of stained spots in intestines is not increased compared to mice without the Kras allele, but size of stained patches increases suggesting sporadic cre activation of Kras which might have a selective advantage for mutant stem cells resulting in clonal expansion and crypt fission

neoplasm
• animals become moribund at 5 weeks of age due to high lung tumor burden

cellular
• numbers of stained spots in intestines is not increased compared to mice without the Kras allele, but size of stained patches increases suggesting sporadic cre activation of Kras which might have a selective advantage for mutant stem cells resulting in clonal expansion and crypt fission




Genotype
MGI:6241534
cn58
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Resttm1.1Yasu/Resttm1.1Yasu
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
Resttm1.1Yasu mutation (1 available); any Rest mutation (51 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• at E14.5, the number of LacZ+ neural crest cell-derived cells in the skin is lower in both the head and belly regions than that in NCC-specific heterozygous knockout littermates carrying only one Resttm1.1Yasu allele

nervous system
• at E14.5, the number of LacZ+ neural crest cell-derived cells in the skin is lower in both the head and belly regions than that in NCC-specific heterozygous knockout littermates carrying only one Resttm1.1Yasu allele




Genotype
MGI:5427701
cn59
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Msx2tm1Rilm/Msx2tm1Rilm
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
Msx2tm1Rilm mutation (1 available); any Msx2 mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• persistent adherence of the lens vesicle to the corneal ectoderm hinders the migration of neural crest cells across the stromal space between the surface ectoderm and endothelium




Genotype
MGI:3833235
cn60
Allelic
Composition
Gt(ROSA)26Sortm1Sor/?
Tg(GH1-cre)1Sac/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(GH1-cre)1Sac mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed




Genotype
MGI:3762370
cn61
Allelic
Composition
Gt(ROSA)26Sortm1Sor/?
Tg(Mylpf-cre)3Kraj/0
Genetic
Background
involves: 129S4/SvJae * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(Mylpf-cre)3Kraj mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• lacZ detection was used to assess expression domain of cre transgene




Genotype
MGI:3806653
cn62
Allelic
Composition
Foxa2tm2.1(cre/Esr1*)Moon/Foxa2tm2.1(cre/Esr1*)Moon
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa2tm2.1(cre/Esr1*)Moon mutation (1 available); any Foxa2 mutation (18 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• no developmental abnormalities are detected




Genotype
MGI:3702510
cn63
Allelic
Composition
Gt(ROSA)26Sortm1Sor/?
Ptf1atm1(cre)Hnak/Ptf1atm1(cre)Hnak
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Ptf1atm1(cre)Hnak mutation (1 available); any Ptf1a mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within about 3 hours of birth

vision/eye
• lack differentiated amacrine cells at E18.5
• almost no GABAergic or glycinergic positive amacrine cells are found in retinal explants cultured for 12 days; however some syntaxin- and calbindin-positive cells do develop indicating retention of a small subpopulation of differentiated amacrine cells
• in retinal explants cultured for 12 days, syntaxin-, PKCalpha- and calbindin-positive cells are disorganized
• at E18.5, beta-gal expressing cells are found scattered in the inner retina, unlike in control mice where these cells are localized in the innermost zone of the neuroblastic layer
• fusion of the ganglion cell layer and the neuroblastic layer results in loss of the inner plexifom layer

nervous system
• lack differentiated amacrine cells at E18.5
• almost no GABAergic or glycinergic positive amacrine cells are found in retinal explants cultured for 12 days; however some syntaxin- and calbindin-positive cells do develop indicating retention of a small subpopulation of differentiated amacrine cells




Genotype
MGI:5543251
cn64
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Pms2tm2(cre)Lisk/Pms2tm2(cre)Lisk
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Pms2tm2(cre)Lisk mutation (0 available); any Pms2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• DNA mismatch repair (measured by cre reversion and activation of the lacZ reporter) is increased about 100 fold relative to mice heterozygous form the Pms2 allele
• average numbers of gastrointestinal tract spots (stained villi) in homozygous Pms2 mutants is 3300 compared to 26 in Pms2 heterozygotes

homeostasis/metabolism
• DNA mismatch repair (measured by cre reversion and activation of the lacZ reporter) is increased about 100 fold relative to mice heterozygous form the Pms2 allele
• average numbers of gastrointestinal tract spots (stained villi) in homozygous Pms2 mutants is 3300 compared to 26 in Pms2 heterozygotes




Genotype
MGI:3802698
cn65
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Wt1tm2(cre/ERT2)Wtp/Wt1+
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Wt1tm2(cre/ERT2)Wtp mutation (1 available); any Wt1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• used for cell lineage tracing




Genotype
MGI:5439604
cn66
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Prdm1tm3(icre)Rob/Prdm1+
Genetic
Background
involves: 129S4/SvJaeSor
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Prdm1tm3(icre)Rob mutation (0 available); any Prdm1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• only used for expression analysis




Genotype
MGI:6209743
cn67
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Mef2ctm1Eno/Mef2ctm1Jjs
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
Mef2ctm1Eno mutation (0 available); any Mef2c mutation (4 available)
Mef2ctm1Jjs mutation (1 available); any Mef2c mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• X-Gal staining of E9.5 embryos showed no obvious defects in neural crest contribution to the branchial arches or craniofacial mesenchyme relative to control embryos




Genotype
MGI:3831923
cn68
Allelic
Composition
Dvl3tm1Awb/Dvl3tm1Awb
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm1(cre)Sev/Isl1+
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (4 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Isl1tm1(cre)Sev mutation (1 available); any Isl1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• at E10.5, E14.5 and E18.5, secondary heart field development is normal




Genotype
MGI:5571359
cn69
Allelic
Composition
Nap1l2tm2.1Ucr/Y
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Nap1l2tm2.1Ucr mutation (1 available); any Nap1l2 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• neural tube defects after deletion of Nap1l2 at E9

nervous system
• neural tube defects after deletion of Nap1l2 at E9




Genotype
MGI:5571358
cn70
Allelic
Composition
Nap1l2tm2.1Ucr/Nap1l2tm2.1Ucr
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Nap1l2tm2.1Ucr mutation (1 available); any Nap1l2 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• neural tube defects after deletion of Nap1l2 at E9

nervous system
• neural tube defects after deletion of Nap1l2 at E9




Genotype
MGI:3720325
cn71
Allelic
Composition
Gt(ROSA)26Sortm1Sor/?
Myctm2Fwa/Myctm2Fwa
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
Myctm2Fwa mutation (2 available); any Myc mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• the coronal suture adjacent to the frontal bone has a curvilinear appearance and fails to fuse at the midline
• at 6 weeks, the frontal bone is defective and mostly composed of a cartilaginous membrane
• at 6 weeks, malleal defects are observed
• however, the incus and stapes are morphologically normal
• at 6 weeks, the manubrium is smaller than normal
• at 6 weeks, the body of the malleus is smaller than normal

hearing/vestibular/ear
• at 6 weeks, malleal defects are observed
• however, the incus and stapes are morphologically normal
• at 6 weeks, the manubrium is smaller than normal
• at 6 weeks, the body of the malleus is smaller than normal

skeleton
• the coronal suture adjacent to the frontal bone has a curvilinear appearance and fails to fuse at the midline
• at 6 weeks, the frontal bone is defective and mostly composed of a cartilaginous membrane
• at 6 weeks, malleal defects are observed
• however, the incus and stapes are morphologically normal
• at 6 weeks, the manubrium is smaller than normal
• at 6 weeks, the body of the malleus is smaller than normal




Genotype
MGI:5009806
cn72
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Id3tm2.1Zhu/Id3tm2.1Zhu
Tg(Lck-cre)#Zhu/0
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Id3tm2.1Zhu mutation (1 available); any Id3 mutation (12 available)
Tg(Lck-cre)#Zhu mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in lymph node, parotid salivary gland, submandibular gland, and lacrimal gland

hematopoietic system
• in lymph node, parotid salivary gland, submandibular gland, and lacrimal gland




Genotype
MGI:4453458
cn73
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tbx1tm3.1Bld/Tbx1tm6(cre)Bld
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tbx1tm3.1Bld mutation (1 available); any Tbx1 mutation (11 available)
Tbx1tm6(cre)Bld mutation (1 available); any Tbx1 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• abnormal lymphatic vessels fail to extend into distal mesentery unlike in wild-type mice
• between E15.5 and E16.5, lymphatic vessels are almost completely lost unlike in wild-type mice




Genotype
MGI:4940091
cn74
Allelic
Composition
Hand2tm1Dsr/Hand2tm2.1Dsr
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Isl1tm1(cre)Tmj/Isl1+
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Hand2tm1Dsr mutation (0 available); any Hand2 mutation (1 available)
Hand2tm2.1Dsr mutation (0 available); any Hand2 mutation (1 available)
Isl1tm1(cre)Tmj mutation (0 available); any Isl1 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• at E9.5, mice exhibit fewer progenitor cells migration into the outflow tract compared with control mice




Genotype
MGI:5524048
cn75
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nhlh2tm2Thbr/Nhlh2tm2Thbr
Tg(Gnrh1-cre)1Dlc/0
Genetic
Background
involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Nhlh2tm2Thbr mutation (0 available); any Nhlh2 mutation (4 available)
Tg(Gnrh1-cre)1Dlc mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• Gnrh+ neurons in the medial preoptic area and posterior hypothalamus
• in the anterior olfactory nucleus




Genotype
MGI:3829882
cn76
Allelic
Composition
Gt(ROSA)26Sortm1Sor/?
Wnt7btm2Amc/Wnt7btm2.1Amc
Tg(Hoxb7-cre)13Amc/0
Genetic
Background
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(Hoxb7-cre)13Amc mutation (1 available)
Wnt7btm2.1Amc mutation (0 available); any Wnt7b mutation (11 available)
Wnt7btm2Amc mutation (1 available); any Wnt7b mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• at E15.5 the collecting ducts are dilated and branch points are less evident




Genotype
MGI:4843924
cn77
Allelic
Composition
Smotm2Amc/Smotm2.1Amc
H2az2Tg(Wnt1-cre)11Rth/0
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S4/SvJaeSor * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
Smotm2.1Amc mutation (0 available); any Smo mutation (7 available)
Smotm2Amc mutation (1 available); any Smo mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice

cardiovascular system
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice

nervous system
• the number of cardiac neural crest cells reaching the outflow tract is moderately reduced compared to in wild-type mice
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice

cellular
• mice exhibit abnormal patterning of cardiac neural crest cells compared to in wild-type mice




Genotype
MGI:6402038
cn78
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Tg(NPHS2-rtTA2*M2)1Jbk/Tg(NPHS2-rtTA2*M2)1Jbk
Tg(tetO-cre)LC1Bjd/0
Genetic
Background
involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(NPHS2-rtTA2*M2)1Jbk mutation (1 available)
Tg(tetO-cre)LC1Bjd mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
N
• doxycycline-treated mice do not exhibit focal segmental glomerulosclerosis




Genotype
MGI:6402037
cn79
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Tg(NPHS2-rtTA2*M2)1Jbk/Tg(NPHS2-rtTA2*M2)1Jbk
Tg(tetO-cre)LC1Bjd/Tg(tetO-cre)LC1Bjd
Genetic
Background
involves: 129S4/SvJaeSor * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(NPHS2-rtTA2*M2)1Jbk mutation (1 available)
Tg(tetO-cre)LC1Bjd mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• in primary podocyte cell cultures from doxycycline-treated mice

homeostasis/metabolism
• in doxycycline-treated mice
• within the first 3 weeks following treatment with a high dose (50 ug/g) of doxycycline
• however, a lower doxycycline dose (15 ug/g) that produces FSGS does not affect lethality

mortality/aging
• within the first 3 weeks following treatment with a high dose (50 ug/g) of doxycycline
• however, a lower doxycycline dose (15 ug/g) that produces FSGS does not affect lethality

renal/urinary system
• in doxycycline-treated mice
• with vacuolization after 10 days in mice treated with doxycycline
• reduced density in mice treated with doxycycline
• from 3 weeks of age, doxycycline-treated mice exhibit focal segmental glomerulosclerosis (FSGS) with adhesions, segmental accumulation of matrix, capillary hyalinosis, loss of capillaries, and declining glomerular numbers through 13 weeks unlike control mice
• however, mice do not develop FSGS when doxycycline is administered antenatally or at 10 and 11 days after birth or when mice are treated with a low dose of doxycycline (1.5 ug/g)
• in doxycycline-treated mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
focal segmental glomerulosclerosis DOID:1312 OMIM:PS603278
J:285673




Genotype
MGI:4438372
cn80
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Cck-cre)CKres/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(Cck-cre)CKres mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• transgenic cre positive animals are obtained with low frequency from crosses with Gt(ROSA)26Sortm1Sor heterozygotes, suggesting that Tg(Cck-cre)CKres carriers may have reduced survival




Genotype
MGI:5475206
cn81
Allelic
Composition
ApcMin/Apc+
Dclk1tm1.1(cre/ERT2)Seno/Dclk1+
Gt(ROSA)26Sortm1(HBEGF)Awai/Gt(ROSA)26Sor+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (11 available); any Apc mutation (59 available)
Dclk1tm1.1(cre/ERT2)Seno mutation (0 available); any Dclk1 mutation (3 available)
Gt(ROSA)26Sortm1(HBEGF)Awai mutation (4 available); any Gt(ROSA)26Sor mutation (540 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• after tamoxifen treatment and a single injection of diphtheria toxin (DT), polyps contain many Dclk1-positive apoptotic tumor cells and are severely injured or collapsed with Dclk1-negative polyps not displaying DT-induced apoptosis

digestive/alimentary system
N
• after tamoxifen treatment and multiple diphtheria toxin injections to ablate Dclk1-positive cells, these cells are absent from the normal intestine with no significant damage to organ architecture observed in the intestine or stomach

endocrine/exocrine glands
N
• after tamoxifen treatment and multiple diphtheria toxin injections to ablate Dclk1-positive cells, no significant damage in organ architecture is observed in the pancreas or gallbladder




Genotype
MGI:5298069
cn82
Allelic
Composition
Lgr5tm1(cre/ERT2)Fjs/Lgr5tm2(DTR/EGFP)Fjs
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Lgr5tm1(cre/ERT2)Fjs mutation (0 available); any Lgr5 mutation (25 available)
Lgr5tm2(DTR/EGFP)Fjs mutation (0 available); any Lgr5 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

digestive/alimentary system
N
• despite loss of crypt basal columnar cells in diphtheria-treated E15 mice, intestinal epithelium homeostasis is normal




Genotype
MGI:3762559
cn83
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Nphs1-cre)33Mska/0
Tg(Nphs1-IL2RA)18Mska/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(Nphs1-cre)33Mska mutation (0 available)
Tg(Nphs1-IL2RA)18Mska mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• proliferation of parietal epithelial cells, not podocytes, is observed; proliferating cells are lacZ-negative, whereas podocytes express beta-galactosidase
• vacuolar degeneration of parietal epithelial cells is observed after LMB2 treatment
• proliferation of parietal epithelial cells, not podocytes, is also seen; proliferating cells are lacZ-negative, whereas podocytes express beta-galactosidase
• vacuolar degeneration of podocytes is observed after LMB2 treatment; podocytes are identified by lacZ staining
• podocytes are lost temporally after LMB2 treatment, correlating with progression of sclerosis
• hyalinosis is seen after LMB2 treatment
• mesangiolysis is seen after LMB2 treatment
• after treatment with the immunotoxin LMB2, transgenic animal rapidly develop glomerulosclerosis
• 18%, 23%, and 60% of glomeruli show segmental or global sclerosis at 10, 14 or 21 days after treatment, respectively

cellular
• proliferation of parietal epithelial cells, not podocytes, is observed; proliferating cells are lacZ-negative, whereas podocytes express beta-galactosidase




Genotype
MGI:3716382
cn84
Allelic
Composition
Emx2tm2(cre)Sia/Emx2+
Gt(ROSA)26Sortm1Sor/?
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Emx2tm2(cre)Sia mutation (1 available); any Emx2 mutation (5 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed
• used for expression analysis only




Genotype
MGI:5052295
cn85
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Sftpc-cre)1Blh/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(Sftpc-cre)1Blh mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• large dilated cysts at E18.5




Genotype
MGI:5428661
cn86
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Recktm2.2Noda/Recktm3.1(cre/ERT2)Noda
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Recktm2.2Noda mutation (1 available); any Reck mutation (34 available)
Recktm3.1(cre/ERT2)Noda mutation (0 available); any Reck mutation (34 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
limbs/digits/tail
• mice exhibit abnormal distribution of Reck+ cells compared with control mice




Genotype
MGI:5662258
cn87
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Tg(Slc26a5-cre)#Jnz/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(Slc26a5-cre)#Jnz mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice exhibit normal behavior, fertility, inner ear morphology and auditory brainstem responses to click stimuli




Genotype
MGI:5784731
cn88
Allelic
Composition
Arid1atm1.1Mag/Arid1atm1.1Mag
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid1atm1.1Mag mutation (0 available); any Arid1a mutation (161 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• shortened outflow tracts
• cardiac outflow tracts of E11.5 embryos show no evidence of conotruncal septation

cellular
• fewer neural crest cells are seen in post-otic and circumpharyngeal streams of E10.5 embryos
• the depth of cardiac outflow tract penetration by neural crest cells is reduced and elongation of the outflow tract apparatus is truncated in E10.5 embryos, resulting in shortened outflow tracts

embryo
• fewer neural crest cells are seen in post-otic and circumpharyngeal streams of E10.5 embryos
• the depth of cardiac outflow tract penetration by neural crest cells is reduced and elongation of the outflow tract apparatus is truncated in E10.5 embryos, resulting in shortened outflow tracts




Genotype
MGI:5775443
cn89
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Pax3Sp-d/Pax3Sp-d
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Pax3Sp-d mutation (1 available); any Pax3 mutation (21 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• muscleless diaphragms
• however, pleuroperitoneal fold-derived muscle connective tissue is present and mice do not develop diaphragmatic hernias




Genotype
MGI:4888572
cn90
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Tex101-icre)2Lzj/0
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(Tex101-icre)2Lzj mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
N
• males display normal fertility and no defects in spermatogenesis




Genotype
MGI:3811271
cn91
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tg(Ggt1-cre)M3Egn/?
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(Ggt1-cre)M3Egn mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:5620019
cn92
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Myogtm1.1(cre/ERT2)Lepr/Myog+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Myogtm1.1(cre/ERT2)Lepr mutation (1 available); any Myog mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed




Genotype
MGI:5620018
cn93
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Myf6tm1.1(cre/ERT2)Lepr/Myf6+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Myf6tm1.1(cre/ERT2)Lepr mutation (1 available); any Myf6 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed




Genotype
MGI:5620017
cn94
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Myl1tm1.1(cre/ERT2)Lepr/Myl1+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Myl1tm1.1(cre/ERT2)Lepr mutation (1 available); any Myl1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed




Genotype
MGI:5620016
cn95
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Myod1tm1.1(cre/ERT2)Lepr/Myod1+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Myod1tm1.1(cre/ERT2)Lepr mutation (1 available); any Myod1 mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed




Genotype
MGI:5620015
cn96
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Pax3tm1.1(cre/ERT2)Lepr/Pax3+
Genetic
Background
involves: 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Pax3tm1.1(cre/ERT2)Lepr mutation (1 available); any Pax3 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed




Genotype
MGI:5474054
cn97
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Tbx5tm1.2Jse/Tbx5tm1.2Jse
Tg(Kcne1-cre/ERT2)1Imos/0
Genetic
Background
involves: 129S4/SvJaeSor * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tbx5tm1.2Jse mutation (0 available); any Tbx5 mutation (17 available)
Tg(Kcne1-cre/ERT2)1Imos mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
N
• tamoxifen-treated mutants have ventricular conduction system (VCS) cellular fate maps indistinguishable from Tbx5-sufficient animals indicating that defects in conditional animals do not result from loss of VCS cells




Genotype
MGI:6402035
cn98
Allelic
Composition
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm1Sor
Tg(PODXL-rtTA*M2)#Mjmr/Tg(PODXL-rtTA*M2)#Mjmr
Tg(tetO-cre)LC1Bjd/Tg(tetO-cre)LC1Bjd
Genetic
Background
involves: 129S/Sv * 129S4/SvJaeSor * BALB/c * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Tg(PODXL-rtTA*M2)#Mjmr mutation (0 available)
Tg(tetO-cre)LC1Bjd mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
N
• doxycycline-treated mice do not exhibit focal segmental glomerulosclerosis




Genotype
MGI:5297821
cn99
Allelic
Composition
Dnmt3atm1Jae/Dnmt3atm1Jae
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Nkx2-2tm2.1Suss/Nkx2-2tm2.1Suss
Tg(Ins2-cre)23Herr/0
Genetic
Background
involves: 129S/Sv * Black Swiss * C57BL/6 * CBA/J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt3atm1Jae mutation (1 available); any Dnmt3a mutation (82 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
Nkx2-2tm2.1Suss mutation (0 available); any Nkx2-2 mutation (9 available)
Tg(Ins2-cre)23Herr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mice exhibit beta to alpha cell transdifferentiation

cellular
• mice exhibit beta to alpha cell transdifferentiation




Genotype
MGI:3831922
cn100
Allelic
Composition
Dvl3tm1Awb/Dvl3tm1Awb
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S/Sv * Black Swiss * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (4 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• at E10.5, E14.5 and E18.5, cardiac neural crest cell development is normal




Genotype
MGI:3775735
cn101
Allelic
Composition
Eomestm1Rob/Eomestm1.1Rob
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (5 available)
Eomestm1.1Rob mutation (0 available); any Eomes mutation (10 available)
Eomestm1Rob mutation (0 available); any Eomes mutation (10 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (540 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• specification of the definitive endoderm is disrupted