All Phenotypes Fcgr3<tm1Jsv> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fcgr3^tm1Jsv
targeted mutation 1, J Sjef Verbeek
MGI:1861924

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fcgr3^tm1Jsv/Fcgr3^tm1Jsv	B6.129P2-Fcgr3^tm1Jsv/J	MGI:3052641
hm2	Fcgr3^tm1Jsv/Fcgr3^tm1Jsv	involves: 129P2/OlaHsd * C57BL/6	MGI:2664960
cx3	Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Sle21^129P2/Ola/Sle21^129P2/Ola	B6.129P2-Fcgr3^tm1Jsv	MGI:5427952
cx4	Fcer1a^tm1Knt/Fcer1a^tm1Knt Fcer2a^tm1Max/Fcer2a^tm1Max Fcgr1^tm1Jsv/Fcgr1^tm1Jsv Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Fcgr3^tm1Jsv/Fcgr3^tm1Jsv	B6.Cg-Fcgr2b^tm1Ttk Fcgr3^tm1Jsv Fcer1a^tm1Knt Fcgr1^tm1Jsv Fcer2a^tm1Max	MGI:3851204
cx5	Fcgr1^tm1Jsv/Fcgr1^tm1Jsv Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Fcgr3^tm1Jsv/Fcgr3^tm1Jsv	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6	MGI:2664970

Allelic Composition	Fcgr3^tm1Jsv/Fcgr3^tm1Jsv
Genetic Background	B6.129P2-Fcgr3^tm1Jsv/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr3^tm1Jsv mutation (5 available); any Fcgr3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal leukocyte cell number ( J:78297 )

increased neutrophil cell number ( J:78297 )

• increase in circulating neutrophils during induced nephritis

abnormal neutrophil physiology ( J:78297 )

• defective attachment to insoluble immune complexes

impaired neutrophil recruitment ( J:78297 )

• in response to induced glomerulonephritis, 75-83% reduction in glomerular neutrophil accumulation

immune system

abnormal leukocyte cell number ( J:78297 )

increased neutrophil cell number ( J:78297 )

• increase in circulating neutrophils during induced nephritis

abnormal neutrophil physiology ( J:78297 )

• defective attachment to insoluble immune complexes

impaired neutrophil recruitment ( J:78297 )

• in response to induced glomerulonephritis, 75-83% reduction in glomerular neutrophil accumulation

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:126520 )

• more frequent disease remission

• lower incidence of anaphylaxis from a second dose of myelin oligodendrocyte glycoprotein

• considerably reduced when induced with myelin oligodendrocyte glycoprotein

• fewer inflammatory foci in the central nervous system

decreased susceptibility to induced arthritis ( J:106191 )

• less cell influx into the synovial layer and joint cavity 3 days after arthritis induction using immune complexes

• knee joint swelling is also reduced relative controls at both 1 and 3 days after induction

• less proteoglycan loss relative to controls at 1 and 3 days after induction

• chondrocyte death 3X the level in controls at 3 days after induction but normal at 1 day on the femoral surface

• chondrocyte cell death is unaffected on the patellar surface

skeleton

decreased susceptibility to induced arthritis ( J:106191 )

• less cell influx into the synovial layer and joint cavity 3 days after arthritis induction using immune complexes

• knee joint swelling is also reduced relative controls at both 1 and 3 days after induction

• less proteoglycan loss relative to controls at 1 and 3 days after induction

• chondrocyte death 3X the level in controls at 3 days after induction but normal at 1 day on the femoral surface

• chondrocyte cell death is unaffected on the patellar surface

Allelic Composition	Fcgr3^tm1Jsv/Fcgr3^tm1Jsv
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr3^tm1Jsv mutation (5 available); any Fcgr3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased mast cell degranulation ( J:35057 )

• peritoneal mast cells fail to degranulate when stimulated with immune complexes

impaired macrophage phagocytosis ( J:35057 )

• greatly diminished phagocytosis of IgG1 opsonized sheep red blood cells

decreased susceptibility to autoimmune hemolytic anemia ( J:83995 )

• decreased autoimmune hemolytic anemia when induced with mouse IgG2a

impaired natural killer cell mediated cytotoxicity ( J:35057 )

• lack antibody dependent NK cell mediated cytotoxicity against L1210 tumor cells

abnormal dendritic cell antigen presentation ( J:83995 )

• deficient antigen presentation by bone marrow dendritic cells

abnormal type I hypersensitivity reaction ( J:83995 )

• the systemic anaphylaxis response after passive sensitization with IgG2a is modified and partially inhibited and mortality is decreased after challenge

• antigen challenge results in an acute hypotensive effect compared to wild-type mice

decreased susceptibility to type II hypersensitivity reaction ( J:35057 )

• lack IgG dependent passive cutaneous anaphylaxis

• complement independent Arthus reaction is eliminated

hematopoietic system

decreased mast cell degranulation ( J:35057 )

• peritoneal mast cells fail to degranulate when stimulated with immune complexes

impaired macrophage phagocytosis ( J:35057 )

• greatly diminished phagocytosis of IgG1 opsonized sheep red blood cells

decreased susceptibility to autoimmune hemolytic anemia ( J:83995 )

• decreased autoimmune hemolytic anemia when induced with mouse IgG2a

impaired natural killer cell mediated cytotoxicity ( J:35057 )

• lack antibody dependent NK cell mediated cytotoxicity against L1210 tumor cells

cellular

decreased mast cell degranulation ( J:35057 )

• peritoneal mast cells fail to degranulate when stimulated with immune complexes

impaired macrophage phagocytosis ( J:35057 )

• greatly diminished phagocytosis of IgG1 opsonized sheep red blood cells

Allelic Composition	Fcgr3^tm1Jsv/Fcgr3^tm1Jsv Sle21^129P2/Ola/Sle21^129P2/Ola
Genetic Background	B6.129P2-Fcgr3^tm1Jsv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr3^tm1Jsv mutation (5 available); any Fcgr3 mutation (29 available)
Sle21^129P2/Ola mutation (0 available); any Sle21 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:179175 )

N	• mice exhibit normal mortality

immune system

enlarged spleen ( J:179175 )

increased spleen weight ( J:179175 )

increased B cell number ( J:179175 )

• increased activated B cell

increased activated T cell number ( J:179175 )

increased anti-chromatin antibody level ( J:179175 )

increased anti-double stranded DNA antibody level ( J:179175 )

increased anti-histone antibody level ( J:179175 )

increased anti-single stranded DNA antibody level ( J:179175 )

hematopoietic system

enlarged spleen ( J:179175 )

increased spleen weight ( J:179175 )

increased B cell number ( J:179175 )

• increased activated B cell

increased activated T cell number ( J:179175 )

growth/size/body

enlarged spleen ( J:179175 )

increased spleen weight ( J:179175 )

Allelic Composition	Fcer1a^tm1Knt/Fcer1a^tm1Knt Fcer2a^tm1Max/Fcer2a^tm1Max Fcgr1^tm1Jsv/Fcgr1^tm1Jsv Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Fcgr3^tm1Jsv/Fcgr3^tm1Jsv
Genetic Background	B6.Cg-Fcgr2b^tm1Ttk Fcgr3^tm1Jsv Fcer1a^tm1Knt Fcgr1^tm1Jsv Fcer2a^tm1Max

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1a^tm1Knt mutation (3 available); any Fcer1a mutation (21 available)
Fcer2a^tm1Max mutation (0 available); any Fcer2a mutation (24 available)
Fcgr1^tm1Jsv mutation (4 available); any Fcgr1 mutation (34 available)
Fcgr2b^tm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Fcgr3^tm1Jsv mutation (5 available); any Fcgr3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal mast cell physiology ( J:144620 )

• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally

• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells

abnormal macrophage physiology ( J:144620 )

• macrophages fail to react to IgE complexes

increased susceptibility to type I hypersensitivity reaction ( J:144620 )

• mice fail to initiate an airway inflammatory response when IgE immune complexes are administered intranasally

hematopoietic system

abnormal mast cell physiology ( J:144620 )

• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally

• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells

abnormal macrophage physiology ( J:144620 )

• macrophages fail to react to IgE complexes

Allelic Composition	Fcgr1^tm1Jsv/Fcgr1^tm1Jsv Fcgr2b^tm1Ttk/Fcgr2b^tm1Ttk Fcgr3^tm1Jsv/Fcgr3^tm1Jsv
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr1^tm1Jsv mutation (4 available); any Fcgr1 mutation (34 available)
Fcgr2b^tm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Fcgr3^tm1Jsv mutation (5 available); any Fcgr3 mutation (29 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired macrophage phagocytosis ( J:83995 )

• phagocytosis of all IgG-IC by macrophages is abrogated

hematopoietic system

impaired macrophage phagocytosis ( J:83995 )

• phagocytosis of all IgG-IC by macrophages is abrogated

cellular

impaired macrophage phagocytosis ( J:83995 )

• phagocytosis of all IgG-IC by macrophages is abrogated

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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