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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fcgr3tm1Jsv
targeted mutation 1, J Sjef Verbeek
MGI:1861924
Summary 5 genotypes


Genotype
MGI:3052641
hm1
Allelic
Composition
Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic
Background
B6.129P2-Fcgr3tm1Jsv/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr3tm1Jsv mutation (5 available); any Fcgr3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• increase in circulating neutrophils during induced nephritis
• defective attachment to insoluble immune complexes
• in response to induced glomerulonephritis, 75-83% reduction in glomerular neutrophil accumulation

immune system
• increase in circulating neutrophils during induced nephritis
• defective attachment to insoluble immune complexes
• in response to induced glomerulonephritis, 75-83% reduction in glomerular neutrophil accumulation
• more frequent disease remission
• considerably reduced when induced with myelin oligodendrocyte glycoprotein
• lower incidence of anaphylaxis from a second dose of myelin oligodendrocyte glycoprotein
• fewer inflammatory foci in the central nervous system
• less cell influx into the synovial layer and joint cavity 3 days after arthritis induction using immune complexes
• knee joint swelling is also reduced relative controls at both 1 and 3 days after induction
• less proteoglycan loss relative to controls at 1 and 3 days after induction
• chondrocyte death 3X the level in controls at 3 days after induction but normal at 1 day on the femoral surface
• chondrocyte cell death is unaffected on the patellar surface

skeleton
• less cell influx into the synovial layer and joint cavity 3 days after arthritis induction using immune complexes
• knee joint swelling is also reduced relative controls at both 1 and 3 days after induction
• less proteoglycan loss relative to controls at 1 and 3 days after induction
• chondrocyte death 3X the level in controls at 3 days after induction but normal at 1 day on the femoral surface
• chondrocyte cell death is unaffected on the patellar surface




Genotype
MGI:2664960
hm2
Allelic
Composition
Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr3tm1Jsv mutation (5 available); any Fcgr3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• greatly diminished phagocytosis of IgG1 opsonized sheep red blood cells

immune system
• greatly diminished phagocytosis of IgG1 opsonized sheep red blood cells
• decreased autoimmune hemolytic anemia when induced with mouse IgG2a
• peritoneal mast cells fail to degranulate when stimulated with immune complexes
• lack antibody dependent NK cell mediated cytotoxicity against L1210 tumor cells
• deficient antigen presentation by bone marrow dendritic cells
• the systemic anaphylaxis response after passive sensitization with IgG2a is modified and partially inhibited and mortality is decreased after challenge
• antigen challenge results in an acute hypotensive effect compared to wild-type mice
• lack IgG dependent passive cutaneous anaphylaxis
• complement independent Arthus reaction is eliminated

hematopoietic system
• greatly diminished phagocytosis of IgG1 opsonized sheep red blood cells
• decreased autoimmune hemolytic anemia when induced with mouse IgG2a
• peritoneal mast cells fail to degranulate when stimulated with immune complexes
• lack antibody dependent NK cell mediated cytotoxicity against L1210 tumor cells




Genotype
MGI:5427952
cx3
Allelic
Composition
Fcgr3tm1Jsv/Fcgr3tm1Jsv
Sle21129P2/Ola/Sle21129P2/Ola
Genetic
Background
B6.129P2-Fcgr3tm1Jsv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr3tm1Jsv mutation (5 available); any Fcgr3 mutation (20 available)
Sle21129P2/Ola mutation (0 available); any Sle21 mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype



Genotype
MGI:3851204
cx4
Allelic
Composition
Fcer1atm1Knt/Fcer1atm1Knt
Fcer2atm1Max/Fcer2atm1Max
Fcgr1tm1Jsv/Fcgr1tm1Jsv
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic
Background
B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1atm1Knt mutation (3 available); any Fcer1a mutation (13 available)
Fcer2atm1Max mutation (0 available); any Fcer2a mutation (17 available)
Fcgr1tm1Jsv mutation (4 available); any Fcgr1 mutation (27 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (39 available)
Fcgr3tm1Jsv mutation (5 available); any Fcgr3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally
• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells
• macrophages fail to react to IgE complexes
• mice fail to initiate an airway inflammatory response when IgE immune complexes are administered intranasally

hematopoietic system
• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally
• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells
• macrophages fail to react to IgE complexes




Genotype
MGI:2664970
cx5
Allelic
Composition
Fcgr1tm1Jsv/Fcgr1tm1Jsv
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcgr1tm1Jsv mutation (4 available); any Fcgr1 mutation (27 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (39 available)
Fcgr3tm1Jsv mutation (5 available); any Fcgr3 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• phagocytosis of all IgG-IC by macrophages is abrogated

immune system
• phagocytosis of all IgG-IC by macrophages is abrogated

hematopoietic system
• phagocytosis of all IgG-IC by macrophages is abrogated





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/04/2022
MGI 6.17
The Jackson Laboratory