About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fastm1Osa
targeted mutation 1, Osaka University Medical School
MGI:1861923
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fastm1Osa/Fastm1Osa involves: 129P2/OlaHsd * C57BL/6 MGI:2450098
cx2
Fastm1Osa/Fastm1Osa
Gzmatm1Simn/Gzmatm1Simn
Gzmbtm1Ley/Gzmbtm1Ley
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 MGI:3589259


Genotype
MGI:2450098
hm1
Allelic
Composition
Fastm1Osa/Fastm1Osa
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Osa mutation (7 available); any Fas mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Histopathology of Fas-deficient mice.

mortality/aging
• 50% dead at about 5 months of age (J:64296)
• 50% dead at about 5 months of age (J:64296)

liver/biliary system
• hepatocyte nuclear areas are variable and larger (J:64296)
• hepatocyte nuclear areas are variable and larger (J:64296)
• significantly heavier at 12 weeks of age and becomes 50-60% heavier by 16 weeks of age (J:64296)
• number of hepatocytes per each liver lobe is increased (J:64296)
• significantly heavier at 12 weeks of age and becomes 50-60% heavier by 16 weeks of age (J:64296)
• number of hepatocytes per each liver lobe is increased (J:64296)

immune system
• peripheral clonal deletion of mature T cells against a bacterial superantigen is impaired (J:32125)
• peripheral clonal deletion of mature T cells against a bacterial superantigen is impaired (J:32125)
• 20x higher than in controls, attributable to increased lymphocyte numbers (J:32125)
• 20x higher than in controls, attributable to increased lymphocyte numbers (J:32125)
• lymphocytosis; progressively accumulate abnromal T cells Thy1+ B220+ CD4- CD8 - (J:64296)
• lymphocytosis; progressively accumulate abnromal T cells Thy1+ B220+ CD4- CD8 - (J:64296)
• increase in the number of normal B cells (J:32125)
• increase in the number of normal B cells (J:32125)
• 10-100x higher serum levels of IgG1, IgG2a, IgG2b, and IgG3 at 16 weeks of age (J:32125)
• 10-100x higher serum levels of IgG1, IgG2a, IgG2b, and IgG3 at 16 weeks of age (J:32125)
• spleen becomes progressively larger (J:64296)
• spleen becomes progressively larger (J:64296)
• lymph nodes become progressively larger (J:64296)
• lymph nodes become progressively larger (J:64296)
• occasional infiltration of lymphocytes into tissues such as the lungs and liver (J:64296)
• occasional infiltration of lymphocytes into tissues such as the lungs and liver (J:64296)
• 50-500x higher levels of dsDNA and ssDNA autoantibodies at 16 weeks of age (J:32125)
• 50-500x higher levels of dsDNA and ssDNA autoantibodies at 16 weeks of age (J:32125)
• decreased survival after infection with Trypanosoma cruzi even though were able to clear parasites from blood and affected organs (J:81397)
• decreased survival after infection with Trypanosoma cruzi even though were able to clear parasites from blood and affected organs (J:81397)

hematopoietic system
• peripheral clonal deletion of mature T cells against a bacterial superantigen is impaired (J:32125)
• peripheral clonal deletion of mature T cells against a bacterial superantigen is impaired (J:32125)
• 20x higher than in controls, attributable to increased lymphocyte numbers (J:32125)
• 20x higher than in controls, attributable to increased lymphocyte numbers (J:32125)
• lymphocytosis; progressively accumulate abnromal T cells Thy1+ B220+ CD4- CD8 - (J:64296)
• lymphocytosis; progressively accumulate abnromal T cells Thy1+ B220+ CD4- CD8 - (J:64296)
• increase in the number of normal B cells (J:32125)
• increase in the number of normal B cells (J:32125)
• spleen becomes progressively larger (J:64296)
• spleen becomes progressively larger (J:64296)
• 10-100x higher serum levels of IgG1, IgG2a, IgG2b, and IgG3 at 16 weeks of age (J:32125)
• 10-100x higher serum levels of IgG1, IgG2a, IgG2b, and IgG3 at 16 weeks of age (J:32125)

Mouse Models of Human Disease
OMIM ID Ref(s)
Autoimmune Lymphoproliferative Syndrome; ALPS 601859 J:32125




Genotype
MGI:3589259
cx2
Allelic
Composition
Fastm1Osa/Fastm1Osa
Gzmatm1Simn/Gzmatm1Simn
Gzmbtm1Ley/Gzmbtm1Ley
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Osa mutation (7 available); any Fas mutation (47 available)
Gzmatm1Simn mutation (3 available); any Gzma mutation (6 available)
Gzmbtm1Ley mutation (4 available); any Gzmb mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• decreased clearance and survival after infection with Trypanosoma cruzi (J:81397)
• decreased clearance and survival after infection with Trypanosoma cruzi (J:81397)





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory