Phenotypes associated with this allele
Allelic Composition |
Dab1tm1Cpr/Dab1tm1Cpr
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Genetic Background |
either: (involves: 129S4/SvJaeSor * BALB/c) or (involves: 129S4/SvJaeSor * C57BL/6) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Cpr mutation
(1 available);
any
Dab1 mutation
(77 available)
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nervous system
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• in vitro migration of neuroblasts and chain formation is disrupted
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• olfactory bulbs contain only 60% of the number of cells in the granule cell layer compared to in wild-type mice
• ependymal zone of the bulb contains fewer cells
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• at P17 and P61, rostral migratory streams of (RMS) neuroblasts are severely disrupted and neuroblasts accumulate in the subventricular zone
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• fewer cells that contribute to the olfactory bulb are found in the granule cell layer
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• neuroblasts and glial cells accumulate in the subventricular zone
• a 15-fold increase in apoptosis in the subventricular zone is observed
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cellular
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• in vitro migration of neuroblasts and chain formation is disrupted
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Cpr mutation
(1 available);
any
Dab1 mutation
(77 available)
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nervous system
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• the neocortical marginal zone is crowded with polymorphic cells unlike in wild-type mice
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• the dentate gyrus is disrupted
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• the pyramidal cells are scattered over a broad region unlike in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Cpr mutation
(1 available);
any
Dab1 mutation
(77 available)
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mortality/aging
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• mice die at day 20 to 30 of unidentified causes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Cpr mutation
(1 available);
any
Dab1 mutation
(77 available)
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nervous system
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• the cortical layers are inverted
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Cpr mutation
(1 available);
any
Dab1 mutation
(77 available)
Dab1tm6Cpr mutation
(0 available);
any
Dab1 mutation
(77 available)
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nervous system
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• disrupted order of neocortical layers
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Cpr mutation
(1 available);
any
Dab1 mutation
(77 available)
Dab1tm2Cpr mutation
(0 available);
any
Dab1 mutation
(77 available)
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behavior/neurological
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• authors state that mice exhibit the same ataxic phenotype as Dab1tm2Cpr homozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Cpr mutation
(1 available);
any
Dab1 mutation
(77 available)
Dab1tm3.1Cpr mutation
(0 available);
any
Dab1 mutation
(77 available)
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nervous system
N |
• mice exhibit a normal cerebellum and preplate splitting
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• late born neurons migrate into the marginal zone unlike in wild-type mice
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• the neocortical marginal zone is thinner than in wild-type mice and crowded with small cells
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• mice exhibit a splitting of the stratum pyramidale in the CA1 region
• the ectopic pyramidal layer is closer to the hippocampal fissure, further from the alveus and becomes the main layer in the CA2 region
• however, the CA3 region and dentate gyrus develop normally
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cellular
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• late born neurons migrate into the marginal zone unlike in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Cpr mutation
(1 available);
any
Dab1 mutation
(77 available)
Dab1tm4Cpr mutation
(0 available);
any
Dab1 mutation
(77 available)
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nervous system
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• the marginal zone of the cortex is reduced compared to mice heterozygous for either allele alone
• at E16.5 cortical plate neurons are more superficial than normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Cpr mutation
(1 available);
any
Dab1 mutation
(77 available)
Rnf7tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Rnf7 mutation
(17 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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nervous system
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• absent as in Dab1tm1Cpr homozygotes
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• inverted cortical plate as in Dab1tm1Cpr homozygotes
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• underdeveloped as in Dab1tm1Cpr homozygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1tm1Cpr mutation
(1 available);
any
Dab1 mutation
(77 available)
Rnf7tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Rnf7 mutation
(17 available)
Tg(Nes-cre)1Kln mutation
(4 available)
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nervous system
N |
• Purkinje cell positioning and cerebellum size are rescued compared to in Rnf7tm1c(EUCOMM)Wtsi/Rnf7tm1c(EUCOMM)Wtsi Tg(Nes-cre)1Kln mice
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nervous system
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• the marginal zone of the cortex is reduced, similar to compound heterozygous mice wild-type for Reln
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• the hippocampus is subtly disorganized in the CA2/3 region compared to mice heterozygous for Dab1tm1Cpr and Relnrl
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