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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cnga2tm1Ngai
targeted mutation 1, J Ngai
MGI:1861912
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cnga2tm1Ngai/Cnga2tm1Ngai involves: 129S1/Sv * FVB/N MGI:3717661
ot2
Cnga2tm1Ngai/Y involves: 129S1/Sv MGI:3717665


Genotype
MGI:3717661
hm1
Allelic
Composition
Cnga2tm1Ngai/Cnga2tm1Ngai
Genetic
Background
involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Ngai mutation (1 available); any Cnga2 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
taste/olfaction
• lilial, octaldehyde, N-pentyl acetate, geraniol, citral, kovanol, valeric acid, ethyl priopionate, menthone, ethyl acetate and 1um forskolin fail to elicit an odor-evoked field potential at low concentration whereas a small response is elicited at high concentration (1-5mM)
• 2,5-dimethyl pyrazine (DMP) and 2-heptanone activate a small number of glomeruli within the olfactory bulb
• 1/40x 1% ethyl acetate activated 3 glomeruli distinct from those activated by DMP and 2-heptanone
• mice cannot detect lilial, octaldehyde, N-pentyl acetate and geraniol




Genotype
MGI:3717665
ot2
Allelic
Composition
Cnga2tm1Ngai/Y
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Ngai mutation (1 available); any Cnga2 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most male pups die 1 to 2 days after birth with empty stomachs from being unable to nurse and cannot locate mother's nipple even in the absence of competition from siblings

taste/olfaction
• the odorant-evoked potential triggered by triethylamine is a rapidly rising positive potential
• 2-hexylpyridine, isomenthone, citrava, geraniol, pyrazine, lilial, ethyvanillin, and isovaleric fail to elicit an odorant-evoked potential
• general anosmia





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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory