Phenotypes associated with this allele

• Allele Symbol: Cdk5^tm1Kul
• Allele Name: targeted mutation 1, Ashok B Kulkarni
• Allele ID: MGI:1861809
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdk5^tm1Kul/Cdk5^tm1Kul	involves: 129S4/SvJae * C57BL/6	MGI:2175754

Genotype
MGI:2175754

hm1

• Allelic Composition: Cdk5^tm1Kul/Cdk5^tm1Kul
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:64289 )

• numbers of homozygous embryos at E18.5 and P0 are 19% and 9%, instead of expected 25%; null mice die within 12 hours of birth

behavior/neurological

absent suckling reflex ( J:64289 )

• no milk in stomach at time of death

unresponsive to tactile stimuli ( J:64289 )

• no response to clamp stimulation of tails at P0

weakness ( J:64289 )

• at P0, surviving homozygotes are weak

abnormal locomotor behavior ( J:64289 )

• living newborns show reduced mobility of all 4 limbs

homeostasis/metabolism

cyanosis ( J:64289 )

• living null animals at P0 exhibit cyanosis and die within 12 hours

respiratory system

hypopnea ( J:64289 )

• living newborn mice display hypopnea

nervous system

abnormal cortical plate morphology ( J:71181 )

• cortical plate is misplaced

abnormal olfactory bulb development ( J:71181 )

• compact layer of mitral cells is absent at E18.5

• various fiber tracts show disrupted formation; medial lemniscus is intact, but other tracts aren't visible such as the solitary tract

• superior and inferior olivary nuclei are absent

abnormal dentate gyrus morphology ( J:71181 )

• indiscernible throughout entire hippocampal formation

abnormal hippocampus layer morphology ( J:64289 , J:71181 )

• stratification is abnormal; pyramidal neurons are not organized discretely (J:64289)

• diffuse laminar organization of CA pyramidal neurons with appearance of cell-free rifts between clusters of cells (J:71181)

abnormal cerebral cortex morphology ( J:71181 )

• cortex shows lamination defects, with clumps of neurons seen; marginal zone is indistinct compared to wild-type

abnormal stratification in cerebral cortex ( J:64289 )

• normal stratification is absent

abnormal cerebellar cortex morphology ( J:64289 )

• tripartite layering is absent

abnormal cerebellar foliation ( J:64289 )

• typical foliation is lacking

abnormal motor neuron morphology ( J:64289 , J:71181 )

• motor neurons show cytoplasmic vacuoles in facial and hypoglossal nerve nuclei (J:64289)

• motor neurons in spinal cord display pathological changes, including chromatolysis, at E18.5 (J:71181)

chromatolysis ( J:71181 )

• seen in some motor neurons at E18.5

abnormal facial nerve morphology ( J:64289 )

• motor neurons show cytoplasmic vacuoles

abnormal hypoglossal nerve morphology ( J:64289 )

• in hypoglossal nerve nuclei, motor neurons show cytoplasmic vacuoles

abnormal spinal cord ventral horn morphology ( J:64289 )

• motor neurons of ventral horn display ballooned perikarya with abnormally positioned nucleus and characteristics suggestive of chromatolytic changes