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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
C3tm1Crr
targeted mutation 1, Michael C Carroll
MGI:1861799
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
C3tm1Crr/C3tm1Crr B6.129S4-C3tm1Crr MGI:3785287
hm2
C3tm1Crr/C3tm1Crr B6;129S4-C3tm1Crr/J MGI:3799624
hm3
C3tm1Crr/C3tm1Crr involves: 129S4/SvJae MGI:3806151
hm4
C3tm1Crr/C3tm1Crr involves: 129S4/SvJae * C57BL/6 MGI:2429606
cx5
C3tm1Crr/C3tm1Crr
Cd59atm1Bpm/Cd59atm1Bpm
B6.129-Cd59atm1Bpm C3tm1Crr MGI:5298854
cx6
C3tm1Crr/C3tm1Crr
Dysftm1Kcam/Dysftm1Kcam
B6.129-Dysftm1Kcam C3tm1Crr MGI:5295996
cx7
C3tm1Crr/C3tm1Crr
Fcer1gtm1Rav/Fcer1gtm1Rav
Tg(Ins2-TFRC/OVA)296Wehi/0
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:3784426
cx8
C3tm1Crr/C3tm1Crr
Tg(Ins2-TFRC/OVA)296Wehi/0
involves: 129S4/SvJae * C57BL/6 MGI:3784424
cx9
C3tm1Crr/C3tm1Crr
Zbtb20Tg(PDGFB-APPSwInd)20Lms/?
involves: 129S4/SvJae * C57BL/6 MGI:5295993
cx10
C3tm1Crr/C3tm1Crr
Faslpr/Faslpr
involves: 129S4/SvJae * C57BL/6 * MRL MGI:3800669
cx11
C3tm1Crr/C3tm1Crr
C4btm1Crr/C4btm1Crr
Faslpr/Faslpr
involves: 129S4/SvJae * C57BL/6 * MRL MGI:3800670
cx12
C3tm1Crr/C3tm1Crr
Del(2Cd59b-Cd59a)1Jha/Del(2Cd59b-Cd59a)1Jha
involves: 129/Sv * 129S4/SvJae * C57BL/6 MGI:4947228


Genotype
MGI:3785287
hm1
Allelic
Composition
C3tm1Crr/C3tm1Crr
Genetic
Background
B6.129S4-C3tm1Crr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (4 available); any C3 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Total area of the placenta is lower in C3tm1Crr/C3tm1Crr mice

behavior/neurological
• 16 month old mutant mice exhibit increased freezing time during initial testing and 24 hours later as compared to age-matched wild-type mice
• 4 month old mutant mice exhibit increased freezing time during training, but not retention
• age-matched 16 month old mutant mice more quickly relearn and retain new platform location than wild-type mice is reversal trial of water T maze
• age-matched 16 month old mutant mice more quickly relearn and retain new platform location than wild-type mice is reversal trial of water T maze
• 16 month old mutant mice spend more ambulatory time in the center of the field than age-matched wild-type mice
• 16 month old mutant mice make more total open arm entries than age-matched wild-type mice
• 16 month old mutant mice make more contacts with novel objects in first minute of test than age-matched wild-type mice

immune system
• mice are resistant to hemolytic anemia induced by self-binding IgG2a antibodies
• no protection is seen with pathogenic IgM or IgA self-antibodies
• neutrophils that accumulate at the site of a local Shwartman response are round instead of flattened as in wild-type mice
• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice fail to exhibit hemorrhage and exhibit reduced fibrin deposition compared to the thrombohemorrhagic vasculitis observed in wild-type mice despite normal neutrophil accumulation
• reduced granulocyte infiltration of infarct sites

homeostasis/metabolism
• mouse serum fails to support neutrophil adhesion unlike serum from wild-type mice
• significantly reduced infarct volume but mortality unaffected

hematopoietic system
• mice are resistant to hemolytic anemia induced by self-binding IgG2a antibodies
• no protection is seen with pathogenic IgM or IgA self-antibodies
• neutrophils that accumulate at the site of a local Shwartman response are round instead of flattened as in wild-type mice

nervous system
• significantly reduced infarct volume but mortality unaffected
• reduced granulocyte infiltration of infarct sites
• mutant mice do not exhibit age-dependent neuron loss in the hippocampal CA3 region from P30 to 16 months
• increased dendritic spine density is observed in the hippocampal CA3 region of 16 month old mice as compared to wild-type
• mutant mice do not exhibit age-dependent neuron loss in the hippocampal CA3 region from P30 to 16 months
• neuron numbers in CA1, V1 cortex and cerebellum are similar to wild-type
• synaptic puncta density in the hippocampal CA3 region is higher in mutant males than in wild-type males at 4 months of age; density is similar to wild-type at P30
• protective effects (to a lesser extent) against synapse loss are also observed in hippocampal DG and V1 regions, but not in the CA1 region, at 16 months of age
• synaptic plasticity is improved as compared to age matched 12 month old wild-type mice
• observed in 12 month old mice as compared to age-matched wild-type
• observed in 12 month old mice as compared to age-matched wild-type

reproductive system
• 5.42 days vs 4.41 days in controls
• insignificantly but consistently reduced level of implantation at day 8

embryo
• blastocyst count at 4 days is consistently but insignificantly lower than in controls
• significantly reduced spongioblast at day 15 of pregnancy
• labyrinth area significantly reduced at day 15 of pregnancy
• reduced placenta area at day 15 of pregnancy

growth/size/body
• reduced fetus/placenta ratio
• significantly reduced fetal weight




Genotype
MGI:3799624
hm2
Allelic
Composition
C3tm1Crr/C3tm1Crr
Genetic
Background
B6;129S4-C3tm1Crr/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (4 available); any C3 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• plasma free polyunsaturdated fatty acid (linoleic acid and arachidonic acid) levels are decreased at 14 months of age

immune system
• mice infected with 500 CFU of S. aureus, show higher numbers of bacterial SFU (intraocular growth) at 24 and 48 hours post-infection, levels are indistinguishable from infected wild-type by 72 hours
• mice show partial protection from intranasal infection with the mouse-adapted SARS-CoV MA15 compared to wild-type controls, showing no significant weight loss, decreased airway resistance associated with airway debris and exhalation force indicating improved respiratory function, reduced lung pathology, reductions in inflammatory monocytes and neutrophils and increases in dendritic cells and alveolar macrophages in the lungs by day 4 postinfection, and reduction in cytokine and chemokine responses in the lungs
• SARS-CoV MA15-infected mice exhibit more airspace inflammation at day 2 postinfection than controls but his is reversed later in infection
• however, SARS-CoV MA15-infected mice show similar levels of viral titers in the lung and ratio of peak expiratory flow as in controls

vision/eye
N
• eyes infected with 500 CFU S. aureus show mild signs of inflammation at 24 and 48 hours but appear normal at 72 hours
• the number of rod bipolar cells is decreased at 14 months of age
• density of horizontal cells is decreased
• ERG b-waves are decreased at 12 months of age but not at younger ages
• the amplitude of the c-wave is reduced at 12 months of age, but not at 8 weeks of age
• however, no other component of the dc-ERG is different
• 24 hours after infection with 500 CFU of S. aureus, mice show a transient loss of b-wave amplitude; this stabilizes at a level of 66% of baseline values, similar to what is seen in eyes of infected wild-type mice

nervous system
• the number of rod bipolar cells is decreased at 14 months of age
• density of horizontal cells is decreased




Genotype
MGI:3806151
hm3
Allelic
Composition
C3tm1Crr/C3tm1Crr
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (4 available); any C3 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• thrombus formation considerably reduced
• albuminuria 1/50 control levels after 0.5ng dose of anti glomerular basement membrane antiserum and 1/13 of control levels after 1 ng of antiserum
• following exposure to ethanol, mice do not develop microvesicular or macrovesicular steatosis of the liver and do not accumulate excessive trglycerides as in wild-type mice
• following exposure to ethanol, mice exhibit a reduced increased in alanine aminotransferase compared to in similarly treated wild-type mice

liver/biliary system
• following exposure to ethanol, mice do not develop microvesicular or macrovesicular steatosis of the liver

renal/urinary system
• albuminuria 1/50 control levels after 0.5ng dose of anti glomerular basement membrane antiserum and 1/13 of control levels after 1 ng of antiserum
• reduced neutrophil infiltration of glomerulus relative to controls when injected with 0.5 mg but not with 1.0mg of anti-glomerular basement membrane antiserum

immune system
• reduced neutrophil infiltration of glomerulus relative to controls when injected with 0.5 mg but not with 1.0mg of anti-glomerular basement membrane antiserum




Genotype
MGI:2429606
hm4
Allelic
Composition
C3tm1Crr/C3tm1Crr
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (4 available); any C3 mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

C3tm1Crr/C3tm1Crr exhibit protection from hepatic ischemia reperfusion injury

mortality/aging
• poor survival (20%) after 30 minutes of ischemia while 70% partial hepatectomy performed
• caecal ligation and puncture (CLP) causes greater mortality in mutants than wild-type in the first 24 hours after CLP (100 vs 20% mortality)
• reconstitution of mice with ip. injection of purified human C3 (HuC3) reduces mortality from 100% to 40% in the first 24 hours

immune system
N
• secondary immune responses are similar in wild-type and mutant mice, so helper T cell function is normal
• B cells from deficient mice show normal proliferative effects in response to surface IgM crosslinking
• after CLP less peritoneal mast cells can be recovered from Cr3-deficient mice compared to controls
• 1 hour after CLP, 50% of peritoneal cells are neutrophils and after 3 hours, 90% are neutrophils while in C3-deficient mice, after 1 hour only 1% and 45% after 3 hours are neutrophils
• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls
• after immunization, wild-type mice develop germinal centers (GC) in ~half of splenic follicles while ~10% of splenic follicles in C3-deficient mice contain GCs
• diameter of GCs are less than that observed in wild-type
• reduced levels at 6 and 24 hours after 6 and 24 hours of reperfusion (J:152533)
• Il-6 production after vitamin D3 stimulation is significantly reduced (J:166640)
• levels of Tnfa in peritoneal lavage fluids are reduced in C3-deficient mice compared to controls at 1 hour (158 mg/pl vs 400 mg/pl) and 3 hours (218 mg/pl vs 663 pg/ml) after CLP
• treatment with HuC3 restores levels of Tnfa production in mutants to wild-type levels
• reduced TNFalpha levels at 6 and 24 hours after 6 and 24 hours of reperfusion
• in an in vitro assay, opsonization with serum from C3-deficient mice and 1% immune rabbit serum only resulted in a 0.2 log10 reduction in GBS CFU compared to a 1.0 log10 reduction by normal mouse serum
• mast cells from mutants 1 or 3 hours after CLP show reduced degranulation compared to wild-type (75% of wild-type cells vs <50% of C3-deficient cells)
• treatment with HuC3 results in comparable levels of mast cell degranulation to wild-type
• in response to immunization with bacteriophage (phiX174), a T cell dependent antigen, C3-deficient mice mount a weak Ig M response but fail to switch to IgG
• when immunized with a 10-fold higher amount of bacteriophage, mice show a weak IgG response but response is still 10-fold lower than wild-type
• mild hepatitis is observed in a small number (1/11) of mice surviving systemic challenge with GBS doses of 102 to 105 CFU upon necropsy 15 days post-challenge; there are aggregates of mononuclear or polymorphonuclear leukocytes in hepatic sinusoids; wild-type animals that receive higher doses of GBS showed similar lesions
• mice challenged with group B Streptococci (GBS) infection become bacteremic within 3 days and die or clear bacteria and survive; C3-deficient mice challenged with GBS infection showed a decreased LD50 dose compared to immunocompetent controls (LD50 dose: control 6.3 x 104 vs. 1.3 x 103 in C3-deficient mice) (J:30152)
• increased mortality from GBS infection compared to controls is limited to the first 3 days after challenge (J:30152)
• when pregnant dams are immunized with immune rabbit serum, pups are not protected against lethal challenge on day 2 of life (15/20 pups die within 48 hours) (J:30152)
• at 1 or 3 hours after CLP, cytocentrifuge preparations or peritoneal fluid from C3-deficient mice have reduced neutrophil counts and large numbers of bacteria, compared to wild-type which have few or no bacteria (J:44240)
• treatment with HuC3 restore neutrophil numbers and enhance bacterial clearance to wild-type levels (J:44240)

cardiovascular system
• upeon reperfusion of ischemic intestine (jejunum), permeability index (PI) of injured C3-deficient mice is reduced compared to control treated wild-type (PI of 2.25 vs 3.26 in controls)

digestive/alimentary system
• mice show less evidence of infarction compared to controls

homeostasis/metabolism
• after 70% partial hepatectomy
• reduced levels at 6 and 24 hours after 6 and 24 hours of reperfusion (J:152533)
• Il-6 production after vitamin D3 stimulation is significantly reduced (J:166640)
• lower levels of myeloperoxidase in livers at 6 and 24 hours of reperfusion
• levels lower during reperfusion after ischemia than in controls
• after 70% partial hepatectomy
• levels of Tnfa in peritoneal lavage fluids are reduced in C3-deficient mice compared to controls at 1 hour (158 mg/pl vs 400 mg/pl) and 3 hours (218 mg/pl vs 663 pg/ml) after CLP
• treatment with HuC3 restores levels of Tnfa production in mutants to wild-type levels
• reduced TNFalpha levels at 6 and 24 hours after 6 and 24 hours of reperfusion
• mice are resistant to ischemia reperfusion-induced renal injury
• serum urea nitrogen is reduced 31% to 55% compared to wild-type mice subjected to ischemia reperfusion
• neutrophil infiltration at the site of injury was reduced

hematopoietic system
• after CLP less peritoneal mast cells can be recovered from Cr3-deficient mice compared to controls
• 1 hour after CLP, 50% of peritoneal cells are neutrophils and after 3 hours, 90% are neutrophils while in C3-deficient mice, after 1 hour only 1% and 45% after 3 hours are neutrophils
• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls
• after immunization, wild-type mice develop germinal centers (GC) in ~half of splenic follicles while ~10% of splenic follicles in C3-deficient mice contain GCs
• diameter of GCs are less than that observed in wild-type
• mast cells from mutants 1 or 3 hours after CLP show reduced degranulation compared to wild-type (75% of wild-type cells vs <50% of C3-deficient cells)
• treatment with HuC3 results in comparable levels of mast cell degranulation to wild-type

liver/biliary system
• histological evidence of injury after 6 and 24 hours of reperfusion following ischemia
• after 70% partial hepatectomy
• increased steatosis after 70% hepatectomy
• impaired hepatocyte proliferation after 30 minutes of ischemia during 70% partial hepatectomy
• mild hepatitis is observed in a small number (1/11) of mice surviving systemic challenge with GBS doses of 102 to 105 CFU upon necropsy 15 days post-challenge; there are aggregates of mononuclear or polymorphonuclear leukocytes in hepatic sinusoids; wild-type animals that receive higher doses of GBS showed similar lesions
• significant hepatic injury after 30 minutes of ischemia during 70% partial hepatectomy
• impaired regenerative response after 70% hepatectomy

nervous system
• locomotor recovery from spinal cord injury occurs more rapidly than in controls
• slight improvement in tissue at 24 hours after injury but considerably improved relative to controls by 72 hours
• grossly normal at 7 days after injury compared to controls which show marked areas of necrosis with vacuolization of cells at day 7 and less pronounced necrosis at day 21

skeleton
• bone marrow cells incubated with 1,25(OH)2 vitamin D3 produce fewer osteoclasts than do cells from controls

cellular
• after 70% partial hepatectomy
• impaired hepatocyte proliferation after 30 minutes of ischemia during 70% partial hepatectomy

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
complement component 3 deficiency DOID:8354 OMIM:613779
J:30152




Genotype
MGI:5298854
cx5
Allelic
Composition
C3tm1Crr/C3tm1Crr
Cd59atm1Bpm/Cd59atm1Bpm
Genetic
Background
B6.129-Cd59atm1Bpm C3tm1Crr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (4 available); any C3 mutation (68 available)
Cd59atm1Bpm mutation (0 available); any Cd59a mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• n CD4+ T cells stimulated with recombinant vaccinia virus glycoprotein 13 (p13) to the same extent as in Cd59atm1Bpm homozygotes

immune system
• n CD4+ T cells stimulated with recombinant vaccinia virus glycoprotein 13 (p13) to the same extent as in Cd59atm1Bpm homozygotes

hematopoietic system
• n CD4+ T cells stimulated with recombinant vaccinia virus glycoprotein 13 (p13) to the same extent as in Cd59atm1Bpm homozygotes




Genotype
MGI:5295996
cx6
Allelic
Composition
C3tm1Crr/C3tm1Crr
Dysftm1Kcam/Dysftm1Kcam
Genetic
Background
B6.129-Dysftm1Kcam C3tm1Crr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (4 available); any C3 mutation (68 available)
Dysftm1Kcam mutation (3 available); any Dysf mutation (128 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• significantly reduced dystrophic phenotype




Genotype
MGI:3784426
cx7
Allelic
Composition
C3tm1Crr/C3tm1Crr
Fcer1gtm1Rav/Fcer1gtm1Rav
Tg(Ins2-TFRC/OVA)296Wehi/0
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (4 available); any C3 mutation (68 available)
Fcer1gtm1Rav mutation (7 available); any Fcer1g mutation (27 available)
Tg(Ins2-TFRC/OVA)296Wehi mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice treated with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse and anti-ovalbumin IgG are completely protected from developing diabetes




Genotype
MGI:3784424
cx8
Allelic
Composition
C3tm1Crr/C3tm1Crr
Tg(Ins2-TFRC/OVA)296Wehi/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (4 available); any C3 mutation (68 available)
Tg(Ins2-TFRC/OVA)296Wehi mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• proliferation of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse in the presence or absence of anti-ovalbumin IgG is enhanced compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice

mortality/aging
N
• mice injected with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse and anti-ovalbumin IgG survive unlike of similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice

immune system
• proliferation of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse in the presence or absence of anti-ovalbumin IgG is enhanced compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice
• mice treated with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse alone exhibit higher a incidence of insulitis than of similarly treated Tg(Ins2-TFRC/OVA)296Wehi and Tg(Ins2-TFRC/OVA)296Wehi Fcer1gtm1Rav/Fcer1gtm1Rav mice
• mice treated with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse without anti-ovalbumin IgG exhibit an IFN-gamma production that is increased 3-fold compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice
• only 40% of mice treated with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse and anti-ovalbumin IgG exhibit diabetes compared to 100% of similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice
• the severity of diabetes induced by Tg(TcraTcrb)1100Mjb CD8+ T cells and anti-ovalbumin IgG is reduced compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice

endocrine/exocrine glands
• mice treated with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse alone exhibit higher a incidence of insulitis than of similarly treated Tg(Ins2-TFRC/OVA)296Wehi and Tg(Ins2-TFRC/OVA)296Wehi Fcer1gtm1Rav/Fcer1gtm1Rav mice

hematopoietic system
• proliferation of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse in the presence or absence of anti-ovalbumin IgG is enhanced compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice




Genotype
MGI:5295993
cx9
Allelic
Composition
C3tm1Crr/C3tm1Crr
Zbtb20Tg(PDGFB-APPSwInd)20Lms/?
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (4 available); any C3 mutation (68 available)
Zbtb20Tg(PDGFB-APPSwInd)20Lms mutation (1 available); any Zbtb20 mutation (46 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• plaque levels are doubled in the hippocampus and mid frontal cortex relative to controls at 17 months of age but normal at 12 months
• plasma amyloid levels are increased 51% at 17 months
• neuron loss in the CA3 region at 17 days relative to controls

immune system

hematopoietic system

homeostasis/metabolism
• plaque levels are doubled in the hippocampus and mid frontal cortex relative to controls at 17 months of age but normal at 12 months
• plasma amyloid levels are increased 51% at 17 months




Genotype
MGI:3800669
cx10
Allelic
Composition
C3tm1Crr/C3tm1Crr
Faslpr/Faslpr
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * MRL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (4 available); any C3 mutation (68 available)
Faslpr mutation (39 available); any Fas mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mutant and Faslpr spleens and lymph nodes do not significantly differ in weight at 10 or 13 weeks; at 17 weeks, LN mass is elevated but not significantly
• lack of autoantibodies (ANA, anti-dsDNA) is observed

renal/urinary system
• pathology score is minimally increased relative to B6.MRL-Faslpr mutants, but no IgG deposition is observed in kidneys




Genotype
MGI:3800670
cx11
Allelic
Composition
C3tm1Crr/C3tm1Crr
C4btm1Crr/C4btm1Crr
Faslpr/Faslpr
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * MRL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (4 available); any C3 mutation (68 available)
C4btm1Crr mutation (1 available); any C4b mutation (64 available)
Faslpr mutation (39 available); any Fas mutation (76 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• spleen mass is significantly increased relative to C3-null, Faslpr or single Faslpr mutants at 17 weeks of age

immune system
• spleen mass is significantly increased relative to C3-null, Faslpr or single Faslpr mutants at 17 weeks of age
• lymph node mass is increased relative to C3-null, Faslpr or single Faslpr mutants at 10 and 13 weeks of age
• frequency of antibody-secreting cells (ASCs) or antibody-forming cells (AFCs) is significantly increased in spleen, bone marrow, and lymph nodes compared to C3-deficient Fas mutants or single Faslpr mutants
• titers of serum ANA are significantly increased at 10 and 17 weeks, compared to single-deficient mice
• anti-dsDNA titers are elevated significantly relative to C4, Fas double mutants

hematopoietic system
• spleen mass is significantly increased relative to C3-null, Faslpr or single Faslpr mutants at 17 weeks of age

renal/urinary system
• increased IgG deposition relative to C3/Fas mutants is observed in kidney sections; deposition is similar to C4/Fas mutants
• more severe glomerular abnormalities are observed relative to C3/Fas mutants, and pathology is similar to that of C4/Fas double mutants




Genotype
MGI:4947228
cx12
Allelic
Composition
C3tm1Crr/C3tm1Crr
Del(2Cd59b-Cd59a)1Jha/Del(2Cd59b-Cd59a)1Jha
Genetic
Background
involves: 129/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (4 available); any C3 mutation (68 available)
Del(2Cd59b-Cd59a)1Jha mutation (0 available); any Del(2Cd59b-Cd59a)1Jha mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• mice exhibit normal hematological parameters





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory