Phenotypes associated with this allele

• Allele Symbol: Bcl3^tm1Ver
• Allele Name: targeted mutation 1, Inder M Verma
• Allele ID: MGI:1861796
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl3^tm1Ver/Bcl3^tm1Ver	involves: 129P2/OlaHsd * FVB/NJ	MGI:3046832

Genotype
MGI:3046832

hm1

• Allelic Composition: Bcl3^tm1Ver/Bcl3^tm1Ver
• Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

absent spleen germinal center ( J:38092 )

• in homozygous null mice, splenic white pulp is devoid of germinal centers

immune system

immune system phenotype ( J:38092 )

N • homozygotes are viable and grossly normal, and produce normal numbers of mature B- and T-cell subsets

absent spleen germinal center ( J:38092 )

• in homozygous null mice, splenic white pulp is devoid of germinal centers

abnormal humoral immune response ( J:38092 )

• naive homozygotes exhibit normal levels of resting immunoglobulins

• however, following immunization with Streptococcus pneumoniae, homozygotes fail to produce antigen-specific antibodies

increased susceptibility to bacterial infection ( J:38092 )

• relative to wild-type, homozygous null mice display a highly increased susceptibility to infection with Streptococcus pneumoniae: their blood smears indicate sepsis and mutants never survive longer than 2 days, irrespective of dosage level

• also, homozygotes are unable to clear Listeria monocytogenes as effectively as wild-type