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Allele Symbol Allele Name Allele ID |
F3tm1Gjb targeted mutation 1, George J Bronze, Jr MGI:1861745 |
| Summary |
3 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mice are dead and dying by E10.5
• Background Sensitivity: no mice survive to E15.5 on a 129 background whereas some mice on a mixed 129X1/SvJ and C57BL/6 background survive passed weaning
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice that are born die within the first week of life due to catastrophic hemorrhage
• however, mice delivered by Cesarean section develop intraabdominal bleeding that is resolved by P5, but these mice die by 4 weeks of age
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• although present in Mendelian ratios at E10.5, 85% of mice die before E11.5
(J:35037)
• Background Sensitivity: most mice die prior to E10.5 on a mixed 129X1/SvJ and C57BL/6 background whereas mice on a 129 background all die by E15.5
(J:41500)
• however, no late gestational lethality is observed
(J:41500)
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• no mice complete gestation
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• severe in most mice at E10.5
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• at E10.5
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• at E10.5, the embryo and yolk sac are nearly bloodless
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• at E10.5, the cardiac cavity is distended unlike in wild-type mice
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• mice develop catastrophic hemorrhage after birth
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• mice delivered by Cesarean section develop intra-abdominal bleeding that is resolved by P5
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• at 4 weeks in mice delivered by Cesarean
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• at 4 weeks in mice delivered by Cesarean
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• at E10.5, mice lack cephalic differentiation unlike wild-type mice
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• severe in most mice at E10.5
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• at E10.5
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• 20% less than wild-type at 3 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite reduced response to endotoxin in vitro, mice exhibit a normal response to endotoxin exposure due to increased F3 production
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• endotoxin-stimulated macrophages exhibit 50% less tissue factor activity compared to in wild-type mice
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• endotoxin-induced whole blood or macrophages produced less CXCL1 than similarly treated wild-type blood or macrophages regardless of inhibition by TNF-alpha
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• endotoxin-induced whole blood or macrophages produced less IL6 than similarly treated wild-type blood or macrophages regardless of inhibition by TNF-alpha
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• endotoxin-stimulated macrophages exhibit 50% less tissue factor activity compared to in wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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