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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Trp63tm1Brd
targeted mutation 1, Allan Bradley
MGI:1861713
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Trp63tm1Brd/Trp63tm1Brd involves: 129S7/SvEvBrd MGI:4355558
hm2
Trp63tm1Brd/Trp63tm1Brd involves: 129S7/SvEvBrd * C57BL/6J MGI:3588183


Genotype
MGI:4355558
hm1
Allelic
Composition
Trp63tm1Brd/Trp63tm1Brd
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm1Brd mutation (0 available); any Trp63 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• skin-derived precursors isolated from E18 rudimentary dermis exhibit 3- to 4-fold more robust self-renewal and 4- to 5-fold more proliferation than wild-type cells




Genotype
MGI:3588183
hm2
Allelic
Composition
Trp63tm1Brd/Trp63tm1Brd
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp63tm1Brd mutation (0 available); any Trp63 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• death occurs within several hours of birth

embryo
• small and misshapen at E11.5

limbs/digits/tail
• small and misshapen at E11.5
• forelimbs truncated
• all are missing
• usually truncated, thinner than normal and deformed
• sometimes absent

skeleton
• all are missing
• usually truncated, thinner than normal and deformed
• sometimes absent
• pelvic girdle usually present but lacking ossification centers

craniofacial
• "abnormal facies"

homeostasis/metabolism
• water loss occurs 30X more rapidly than in controls, a skin permeability problem

integument
• skin at birth totally lacks hair follicles
• reduced to a single layer of flattened cells
• epithelium of tongue and oral cavity is similar to the epidermis
• epidermal development apparently stops around E9.5
• water loss occurs 30X more rapidly than in controls, a skin permeability problem

growth/size/body
• "abnormal facies"





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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory