Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfbtm1Hrc mutation
(1 available);
any
Cfb mutation
(29 available)
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immune system
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• antibody-mediated complement of sera is severely impaired as measured by C3 activation in the presence of OVA and anti-OVA immunoglobulins
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• mice show some protection from intranasal infection with the mouse-adapted SARS-CoV MA15 , showing less weight loss than in wild-type controls, but more weight loss than in C3tm1Crr homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfbtm1Hrc mutation
(1 available);
any
Cfb mutation
(29 available)
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immune system
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• total hemolytic complement activation was reduced 50% in mutant sera
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• serum from mutant mice showed no evidence of C3 deposition on zymosan
• serum from mutant mice did not support in vitro cleavage of C3 by cobra venom factor
• alternative pathway-dependent hemolytic activity was undetectable in mutant serum
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reproductive system
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• partial penetrance; only seen in mice derived from one of four ES cell clones
• this effect is most evident in the F1 generation and it appears to be lost upon breeding to the C57BL/6 strain
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfbtm1Hrc mutation
(1 available);
any
Cfb mutation
(29 available)
Cfhtm1Mbo mutation
(0 available);
any
Cfh mutation
(93 available)
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normal phenotype
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• at 2 months of age, double homozygotes have normal amounts of plasma C3, with no evidence of capillary wall glomerular C3 deposition and subendothelial electron-dense deposits
• unlike Cfhtm1Mbo mice, double homozygotes show normal kidney histology and function with no evidence of GBM abnormalities at 8 months of age
• also unlike Cfhtm1Mbo mice which develop severe renal disease within 5 days of receiving sheep nephrotoxic serum (NTS), double homozygotes remain healthy at this stage
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|
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cfbtm1Hrc mutation
(1 available);
any
Cfb mutation
(29 available)
Cfhtm1Mbo mutation
(0 available);
any
Cfh mutation
(93 available)
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immune system
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• at 2 months of age, mutant mice show undetectable plasma C3 levels
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renal/urinary system
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• at 2 months of age, mutant mice exhibit both capillary wall glomerular C3 deposition and subendothelial electron-dense deposits
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homeostasis/metabolism
Analysis Tools