Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MipCts mutation
(1 available);
any
Mip mutation
(31 available)
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vision/eye
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• dispositions of lens fibers and unequal size of fiber nuclei are noticed at E15
• the anterior pole of the lens can have masses of degenerated lens fibers interspersed with vacuoles during fetal development
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• initial changes in lens structure occur at E15 when lens fibers around the lenticular nucleus swell and transform into spindle shapes
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• mice have cataracts when eyes are first opened
• initial changes in lens structure occur at E15 when lens fibers around the lenticular nucleus swell and transform into spindle shapes
• dispositions of lens fibers and unequal size of fiber nuclei are also noticed at this stage
• the anterior pole of the lens can have masses of degenerated lens fibers interspersed with vacuoles
• these morphological lens changes progress gradually into cataracts
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• microphthalmia is noted when eyes are first opened with eyes being about half the size of controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MipCts mutation
(1 available);
any
Mip mutation
(31 available)
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vision/eye
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• all mice of this inbred strain were found to have abnormal lense structure with the lenses spaced with vacuoles
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• in all mice of this inbred background
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• in all mice of this inbred background, but heterozygotes from an outcross to C57BL/6J do not have microphthalmia
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Allelic Composition |
MipCts/MipCts
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Genetic Background |
involves: Jcl:ICR |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MipCts mutation
(1 available);
any
Mip mutation
(31 available)
|
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vision/eye
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• all mice are affected
• either one or both eyes show opacity of the lens
• a milky-white spot is easily visible in the lens of affected eyes
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• mice have small eyes with the lens about half the size of controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MipCts mutation
(1 available);
any
Mip mutation
(31 available)
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vision/eye
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• 73.9% of mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy
• 26.1% of mice have more severe cataracts that are clearly visible to the eye
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MipCts mutation
(1 available);
any
Mip mutation
(31 available)
|
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|
vision/eye
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• 19.9% of mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy
• 80.1% of mice have more severe cataracts that are clearly visible to the eye
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MipCts mutation
(1 available);
any
Mip mutation
(31 available)
|
|
|
vision/eye
|
• all mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MipCts mutation
(1 available);
any
Mip mutation
(31 available)
|
|
|
vision/eye
|
• 7.1% of mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy
• 92.9% of mice have more severe cataracts that are clearly visible to the eye
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Allelic Composition |
MipCts/Mip+
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Genetic Background |
(CTS/Shi x C57BL/6J)F1 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MipCts mutation
(1 available);
any
Mip mutation
(31 available)
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vision/eye
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• 100% of heterozygous F1 mice develop cataracts, but these are less well-developed than those of homozygous CTS/Shi mice and they do not display microphthalmia
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MipCts mutation
(1 available);
any
Mip mutation
(31 available)
|
|
|
vision/eye
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• 91.5% of mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy
• 8.5% of mice have more severe cataracts that are clearly visible to the eye
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Allelic Composition |
MipCts/Mip+
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Genetic Background |
involves: C57BL/6J * CTS/Shi |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MipCts mutation
(1 available);
any
Mip mutation
(31 available)
|
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vision/eye
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• heterozgyotes in the N2 to C57BL/6J population have bilateral cataracts less severe than in CTS/Shi homozygotes, and lack the microphthalmia of homozygotes
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Allelic Composition |
MipCts/Mip+
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Genetic Background |
involves: Jcl:ICR |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MipCts mutation
(1 available);
any
Mip mutation
(31 available)
|
|
|
vision/eye
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• all mice are affected
• either one or both eyes show opacity of a normal-sized lens
• a milky-white spot is easily visible in the lens of affected eyes
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