• no immune system abnormalites are detected (J:60782)

• 52% of P13 mice and 57% of adult mice have enlarged lateral ventricles

• area of the ipsilateral projection is increased compared to controls

• in some cases, multiple ectopic clusters of inputs are present in the medial areas of the LGN

• retinogeniculate axons, glomeruli and bouton appear normal

• increase in size of excitatory presynaptic boutons

• mice exhibit significantly fewer perforations at hippocampal synapses that wild-type

• presynaptic nerve terminals contain 10% more synaptic vesicles than wild-type

• LTP in response to tetanus is enhanced by approximately 227% as compared to wild type

• 40% increase in frequency in hippocampal neurons

• 100% increase in frequency in layer 4 cortical neurons

• median amplitude is similar to wild-type in hippocampal and layer 4 neurons

• treatment with the neural activity blocker, Tetrodotoxin (TTX), does not increase mEPSC in mutant hippocampal cultures in contrast to increases in both amplitude and frequency observed in wild-type

• 900 pulses at 1 Hz enhances baseline LTD, but LTD is unchanged in wild-type

• 900 pulses at 0.5 Hz does not induce significant LTD in contrast to wild-type response

• mice that survive beyond 30 weeks exhibit a multitude of tumors types (erythroid, intestine, skin, uterus, mammary gland, lung, intestine, and hereditary nonpolyposis colorectal cancer)

• in mice that survive beyond 30 weeks

• 80% of mice that survive beyond 30 weeks develop Hereditary Nonpolyposis Colon Cancer (HNPCC) tumors

• in mice that survive beyond 30 weeks

• in mice that survive beyond 30 weeks (J:45433)

• in mice that survive beyond 30 weeks

• in mice that survive beyond 30 weeks