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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tap1tm1Hpl
targeted mutation 1, Hidde Ploegh
MGI:1858161
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tap1tm1Hpl/Tap1tm1Hpl either: (involves: 129S2/SvPas * 129/Ola) or (involves: 129S2/SvPas * FVB) MGI:2175691
cx2
B2mtm1Jae/B2mtm1Jae
Tap1tm1Hpl/Tap1tm1Hpl
B6.129-B2mtm1Jae Tap1tm1Hpl MGI:5009810
cx3
Msh2tm1Htr/Msh2tm1Htr
Tap1tm1Hpl/Tap1tm1Hpl
involves: 129P2/OlaHsd * FVB MGI:4429609


Genotype
MGI:2175691
hm1
Allelic
Composition
Tap1tm1Hpl/Tap1tm1Hpl
Genetic
Background
either: (involves: 129S2/SvPas * 129/Ola) or (involves: 129S2/SvPas * FVB)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tap1tm1Hpl mutation (1 available); any Tap1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• no immune system abnormalites are detected




Genotype
MGI:5009810
cx2
Allelic
Composition
B2mtm1Jae/B2mtm1Jae
Tap1tm1Hpl/Tap1tm1Hpl
Genetic
Background
B6.129-B2mtm1Jae Tap1tm1Hpl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2mtm1Jae mutation (4 available); any B2m mutation (46 available)
Tap1tm1Hpl mutation (1 available); any Tap1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 52% of P13 mice and 57% of adult mice have enlarged lateral ventricles
• area of the ipsilateral projection is increased compared to controls
• in some cases, multiple ectopic clusters of inputs are present in the medial areas of the LGN
• retinogeniculate axons, glomeruli and bouton appear normal
• increase in size of excitatory presynaptic boutons
• mice exhibit significantly fewer perforations at hippocampal synapses that wild-type
• presynaptic nerve terminals contain 10% more synaptic vesicles than wild-type
• LTP in response to tetanus is enhanced by approximately 227% as compared to wild type
• 40% increase in frequency in hippocampal neurons
• 100% increase in frequency in layer 4 cortical neurons
• median amplitude is similar to wild-type in hippocampal and layer 4 neurons
• treatment with the neural activity blocker, Tetrodotoxin (TTX), does not increase mEPSC in mutant hippocampal cultures in contrast to increases in both amplitude and frequency observed in wild-type
• 900 pulses at 1 Hz enhances baseline LTD, but LTD is unchanged in wild-type
• 900 pulses at 0.5 Hz does not induce significant LTD in contrast to wild-type response




Genotype
MGI:4429609
cx3
Allelic
Composition
Msh2tm1Htr/Msh2tm1Htr
Tap1tm1Hpl/Tap1tm1Hpl
Genetic
Background
involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation (0 available); any Msh2 mutation (62 available)
Tap1tm1Hpl mutation (1 available); any Tap1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• in mice that survive beyond 30 weeks

endocrine/exocrine glands
• in mice that survive beyond 30 weeks

digestive/alimentary system
• 80% of mice that survive beyond 30 weeks develop Hereditary Nonpolyposis Colon Cancer (HNPCC) tumors

reproductive system
• in mice that survive beyond 30 weeks

neoplasm
• mice that survive beyond 30 weeks exhibit a multitude of tumors types (erythroid, intestine, skin, uterus, mammary gland, lung, intestine, and hereditary nonpolyposis colorectal cancer)
• 80% of mice that survive beyond 30 weeks develop Hereditary Nonpolyposis Colon Cancer (HNPCC) tumors
• in mice that survive beyond 30 weeks
• in mice that survive beyond 30 weeks
• in mice that survive beyond 30 weeks
• in mice that survive beyond 30 weeks

integument
• in mice that survive beyond 30 weeks
• in mice that survive beyond 30 weeks

Mouse Models of Human Disease
OMIM ID Ref(s)
Lynch Syndrome I 120435 J:45433





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory