Mouse Genome Informatics
hm1
    Mettm1Cpo/Mettm1Cpo
involves: 129S1/Sv * 129X1/SvJ
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
N
• mice exhibit normal numbers of motor neurons in the spinal cord (J:174591)
• cutaneous maximus nerves exhibit pronounced axonal growth defects compared with wild-type nerves
• cultured motor neurons fail to exhibit an effect on neuron survival in response to HGF treatment compared with similarly treated wild-type mice

cellular
• cutaneous maximus nerves exhibit pronounced axonal growth defects compared with wild-type nerves


Mouse Genome Informatics
hm2
    Mettm1Cpo/Mettm1Cpo
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
muscle
N
• abdominal muscles and tail muscles are normal (J:98439)
• perineal muscles are absent at E15 in all embryos examined, with only 2 muscles in pelvic region present; all hindlimb muscles are absent


Mouse Genome Informatics
hm3
    Mettm1Cpo/Mettm1Cpo
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• no live embryos beyond E17.5
• embryonic death starts at E13.5

embryogenesis

growth/size/body
• tip of tongue lacked muscle

muscle
• tip of tongue lacked muscle
• myotubes completely absent in forelimbs
• absent

craniofacial
• tip of tongue lacked muscle

digestive/alimentary system
• tip of tongue lacked muscle


Mouse Genome Informatics
ht4
    Mettm1Cpo/Mettm2Cpo
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• animals die within a few minutes after birth due to respiratory failure
• animals display curled fetal position

muscle
• reduced total muscle mass

respiratory system


Mouse Genome Informatics
cn5
    Mettm1Cpo/Mettm1Sst
Tg(Nes-cre)1Kln/?

involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
vision/eye
N
• no effect on retinal ganglion cell survival after optic nerve axotomy (J:173661)


Mouse Genome Informatics
cn6
    Mettm1Cpo/Mettm1Sst
Tg(Nes-cre)1Kln/0

involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• mice exhibit reduced motor axon arborization (length and number of branches) in the pectoralis minor muscle compared with wild-type mice
• at P2, endplates in the pectoralis minor exhibit increased partially or completely denervated synapses compared with wild-type endplates
• however, mice exhibit normal innervation of the pectoralis minor muscle at E15.5 and of the pectoralis major
• by P2 in the C8 and T1 region of the spinal cord with no further reduction in adult mice
• mice exhibit reduced motor axon arborization (length and number of branches) in the pectoralis minor muscle compared with wild-type mice
• at P2, endplates in the pectoralis minor exhibit increased partially or completely denervated synapses compared with wild-type endplates
• however, mice exhibit normal innervation of the pectoralis minor muscle at E15.5 and of the pectoralis major

behavior/neurological
• in a wire hang test but not a rotarod


Mouse Genome Informatics
cx7
    Mettm1Cpo/Met+
Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+

involves: 129 * BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
embryogenesis
N
• ectopic somite delamination is not seen, unlike in Pax3tm2.1(PAX3/FOXO1A)Buck single heterozygotes (J:86911)


Mouse Genome Informatics
cx8
    Mettm1Cpo/Mettm1Cpo
Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+

involves: 129 * BALB/c * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
embryogenesis
N
• complete rescue of the Pax3tm2.1(PAX3/FOXO1A)Buck single heterozygote somite phenotype (J:86911)