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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mettm1Cpo
targeted mutation 1, Carola Ponzetto
MGI:1858019
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mettm1Cpo/Mettm1Cpo involves: 129S1/Sv * 129X1/SvJ MGI:5285659
hm2
Mettm1Cpo/Mettm1Cpo involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3773054
hm3
Mettm1Cpo/Mettm1Cpo involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2450979
ht4
Mettm1Cpo/Mettm2Cpo involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2450977
cn5
Mettm1Cpo/Mettm1Sst
Tg(Nes-cre)1Kln/?
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL MGI:5052134
cn6
Mettm1Cpo/Mettm1Sst
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:5285657
cx7
Mettm1Cpo/Mettm1Cpo
Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
involves: 129 * BALB/c * C57BL/6 MGI:3690115
cx8
Mettm1Cpo/Met+
Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
involves: 129 * BALB/c * C57BL/6 MGI:3690114


Genotype
MGI:5285659
hm1
Allelic
Composition
Mettm1Cpo/Mettm1Cpo
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Cpo mutation (0 available); any Met mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal numbers of motor neurons in the spinal cord
• cutaneous maximus nerves exhibit pronounced axonal growth defects compared with wild-type nerves
• cultured motor neurons fail to exhibit an effect on neuron survival in response to HGF treatment compared with similarly treated wild-type mice

cellular
• cutaneous maximus nerves exhibit pronounced axonal growth defects compared with wild-type nerves




Genotype
MGI:3773054
hm2
Allelic
Composition
Mettm1Cpo/Mettm1Cpo
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Cpo mutation (0 available); any Met mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
N
• abdominal muscles and tail muscles are normal
• perineal muscles are absent at E15 in all embryos examined, with only 2 muscles in pelvic region present; all hindlimb muscles are absent




Genotype
MGI:2450979
hm3
Allelic
Composition
Mettm1Cpo/Mettm1Cpo
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Cpo mutation (0 available); any Met mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• embryonic death starts at E13.5
• no live embryos beyond E17.5

embryo

growth/size/body
• tip of tongue lacked muscle

muscle
• tip of tongue lacked muscle
• myotubes completely absent in forelimbs
• absent

craniofacial
• tip of tongue lacked muscle

digestive/alimentary system
• tip of tongue lacked muscle




Genotype
MGI:2450977
ht4
Allelic
Composition
Mettm1Cpo/Mettm2Cpo
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Cpo mutation (0 available); any Met mutation (28 available)
Mettm2Cpo mutation (0 available); any Met mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals die within a few minutes after birth due to respiratory failure
• animals display curled fetal position

muscle
• reduced total muscle mass

respiratory system




Genotype
MGI:5052134
cn5
Allelic
Composition
Mettm1Cpo/Mettm1Sst
Tg(Nes-cre)1Kln/?
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Cpo mutation (0 available); any Met mutation (28 available)
Mettm1Sst mutation (1 available); any Met mutation (28 available)
Tg(Nes-cre)1Kln mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
N
• no effect on retinal ganglion cell survival after optic nerve axotomy




Genotype
MGI:5285657
cn6
Allelic
Composition
Mettm1Cpo/Mettm1Sst
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Cpo mutation (0 available); any Met mutation (28 available)
Mettm1Sst mutation (1 available); any Met mutation (28 available)
Tg(Nes-cre)1Kln mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• mice exhibit reduced motor axon arborization (length and number of branches) in the pectoralis minor muscle compared with wild-type mice
• at P2, endplates in the pectoralis minor exhibit increased partially or completely denervated synapses compared with wild-type endplates
• however, mice exhibit normal innervation of the pectoralis minor muscle at E15.5 and of the pectoralis major
• by P2 in the C8 and T1 region of the spinal cord with no further reduction in adult mice
• mice exhibit reduced motor axon arborization (length and number of branches) in the pectoralis minor muscle compared with wild-type mice
• at P2, endplates in the pectoralis minor exhibit increased partially or completely denervated synapses compared with wild-type endplates
• however, mice exhibit normal innervation of the pectoralis minor muscle at E15.5 and of the pectoralis major

behavior/neurological
• in a wire hang test but not a rotarod




Genotype
MGI:3690115
cx7
Allelic
Composition
Mettm1Cpo/Mettm1Cpo
Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
Genetic
Background
involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Cpo mutation (0 available); any Met mutation (28 available)
Pax3tm2.1(PAX3/FOXO1A)Buck mutation (0 available); any Pax3 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• complete rescue of the Pax3tm2.1(PAX3/FOXO1A)Buck single heterozygote somite phenotype




Genotype
MGI:3690114
cx8
Allelic
Composition
Mettm1Cpo/Met+
Pax3tm2.1(PAX3/FOXO1A)Buck/Pax3+
Genetic
Background
involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mettm1Cpo mutation (0 available); any Met mutation (28 available)
Pax3tm2.1(PAX3/FOXO1A)Buck mutation (0 available); any Pax3 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
N
• ectopic somite delamination is not seen, unlike in Pax3tm2.1(PAX3/FOXO1A)Buck single heterozygotes





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory