About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bmp8atm1Blh
targeted mutation 1, Brigid L Hogan
MGI:1857953
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bmp8atm1Blh/Bmp8atm1Blh involves: 129S6/SvEvTac * Black Swiss MGI:2450604
ht2
Bmp8atm1Blh/Bmp8a+ involves: 129S6/SvEvTac * Black Swiss MGI:2450606
cx3
Bmp8atm1Blh/Bmp8a+
Bmp8btm1Blh/Bmp8b+
involves: 129/Sv * 129S6/SvEvTac * Black Swiss MGI:2450605
cx4
Bmp7tm1Rob/Bmp7+
Bmp8atm1Blh/Bmp8atm1Blh
involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss MGI:2451055
cx5
Bmp7tm1Rob/Bmp7+
Bmp8atm1Blh/Bmp8atm1Blh
involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6 MGI:2451053


Genotype
MGI:2450604
hm1
Allelic
Composition
Bmp8atm1Blh/Bmp8atm1Blh
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8atm1Blh mutation (0 available); any Bmp8a mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• 47% of 12 to 30 wk old mutant mice exhibit varying degrees of germ cell degeneration in 1% to 50% of seminiferous tubules
• degeneration is predominantly through apoptosis
• increase in number of apoptotic pachytene spermatocytes
• present but abnormal
• compromised or absent spermiogenesis in many seminiferous tubules
• granulomatous inflammation is sometimes noted in the epididymal tubules of breeding male mice
• male mice are initially fertile, however, 2 of 16 mice become infertile with age; females are fertile

immune system
• sometimes noted in the epididymal tubules of breeding male mice

endocrine/exocrine glands

cellular
• 47% of 12 to 30 wk old mutant mice exhibit varying degrees of germ cell degeneration in 1% to 50% of seminiferous tubules
• degeneration is predominantly through apoptosis
• increase in number of apoptotic pachytene spermatocytes




Genotype
MGI:2450606
ht2
Allelic
Composition
Bmp8atm1Blh/Bmp8a+
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8atm1Blh mutation (0 available); any Bmp8a mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• about 17% of male mice examined exhibited abnormalities similar to homozygous mutant mice

reproductive system
• about 17% of male mice examined exhibited abnormalities similar to homozygous mutant mice
• about 17% of male mice examined exhibited abnormalities similar to homozygous mutant mice




Genotype
MGI:2450605
cx3
Allelic
Composition
Bmp8atm1Blh/Bmp8a+
Bmp8btm1Blh/Bmp8b+
Genetic
Background
involves: 129/Sv * 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp8atm1Blh mutation (0 available); any Bmp8a mutation (13 available)
Bmp8btm1Blh mutation (1 available); any Bmp8b mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• about half of male mice examined exhibited abnormalities similar to homozygous Bmp8atm1Blh mice

reproductive system
• about half of male mice examined exhibited abnormalities similar to homozygous Bmp8atm1Blh mice
• about 50% of male mice examined exhibited abnormalities similar to Bmp8atm1Blh/ Bmp8atm1Blh mice
• is sometimes observed

immune system
• is sometimes noted in the epididymal tubules of breeding male mice




Genotype
MGI:2451055
cx4
Allelic
Composition
Bmp7tm1Rob/Bmp7+
Bmp8atm1Blh/Bmp8atm1Blh
Genetic
Background
involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp7tm1Rob mutation (2 available); any Bmp7 mutation (21 available)
Bmp8atm1Blh mutation (0 available); any Bmp8a mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• average testes weights were comparable at 2 and 4 weeks of age and reduced at 6 and 13 weeks of age relative to age matched Bmp8atm1Blh homozygous mutant

reproductive system
• average testes weights were comparable at 2 and 4 weeks of age and reduced at 6 and 13 weeks of age relative to age matched Bmp8atm1Blh homozygous mutant
• similar epididymal phenotype as Bmp8atm1Blh homozygous mutant mice




Genotype
MGI:2451053
cx5
Allelic
Composition
Bmp7tm1Rob/Bmp7+
Bmp8atm1Blh/Bmp8atm1Blh
Genetic
Background
involves: 129S/SvEv * 129S6/SvEvTac * Black Swiss * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp7tm1Rob mutation (2 available); any Bmp7 mutation (21 available)
Bmp8atm1Blh mutation (0 available); any Bmp8a mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• higher incidence of germ cell degeneration than in homozygous mutant mice, observed in 40 to 80% of examined seminiferous tubules

immune system
• granuloma formation more pronounced than in Bmp8atm1Blh homozygous mutant mice

reproductive system
• higher incidence of germ cell degeneration than in homozygous mutant mice, observed in 40 to 80% of examined seminiferous tubules
• blockage and accumulation of sperm
• 67% exhibited severe epididymal degeneration
• 75% of male mice were infertile





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/14/2020
MGI 6.14
The Jackson Laboratory