Mouse Genome Informatics
hm1
    Tcirg1tm1Ypl/Tcirg1tm1Ypl
involves: 129S4/SvJae * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• die by 5 weeks of age; survival to 12 weeks when fed with milk of foster mothers

growth/size/body
• 70% reduced weight at 23 days of age when compared to littermates

craniofacial

limbs/digits/tail

skeleton
• loss of extracellular acidification function
• narrow; 80% reduced space compared to controls
• thin and fragile

immune system
• loss of extracellular acidification function

hematopoietic system
• loss of extracellular acidification function

Mouse Models of Human Disease
OMIM IDRef(s)
Osteopetrosis, Autosomal Recessive 1; OPTB1 259700 J:58795