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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mlh1tm1Lisk
targeted mutation 1, Michael Liskay
MGI:1857946
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mlh1tm1Lisk/Mlh1tm1Lisk involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:3848461
hm2
 		Mlh1tm1Lisk/Mlh1tm1Lisk involves: 129S7/SvEvBrd MGI:2663872
hm3
 		Mlh1tm1Lisk/Mlh1tm1Lisk involves: 129S7/SvEvBrd * C57BL/6 MGI:5688717
cx4
 		Dnmt1tm1Jae/Dnmt1tm1Pwl
Mlh1tm1Lisk/Mlh1tm1Lisk 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:3848460
cx5
 		Dnmt1tm1Pwl/Dnmt1+
Mlh1tm1Lisk/Mlh1tm1Lisk 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:3848458
cx6
 		Dnmt1tm1Jae/Dnmt1+
Mlh1tm1Lisk/Mlh1tm1Lisk 		involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 MGI:3848459
cx7
 		Meikintm1Yow/Meikintm1Yow
Mlh1tm1Lisk/Mlh1tm1Lisk 		involves: 129S7/SvEvBrd * C57BL/6 MGI:5688722


Genotype
MGI:3848461
hm1
Allelic
Composition		 Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:75745 )
• survival is 65% at 9 months
preweaning lethality, incomplete penetrance ( J:75745 )
• fewer than expected mice are observed (no time of death given)

neoplasm
increased intestinal adenocarcinoma incidence ( J:75745 )
• by 9 months, 83% of mice develop adenomas or adenocarcinomas in the intestinal tract
increased intestinal adenoma incidence ( J:75745 )
• by 9 months, 83% of mice develop adenomas or adenocarcinomas in the intestinal tract
increased lymphoma incidence ( J:75745 )
• in 21% of mice by 9 months of age
increased uterus tumor incidence ( J:75745 )
• one mouse developed a tumor of the uterine epithelium

integument

reproductive system
increased uterus tumor incidence ( J:75745 )
• one mouse developed a tumor of the uterine epithelium

digestive/alimentary system
increased intestinal adenocarcinoma incidence ( J:75745 )
• by 9 months, 83% of mice develop adenomas or adenocarcinomas in the intestinal tract
increased intestinal adenoma incidence ( J:75745 )
• by 9 months, 83% of mice develop adenomas or adenocarcinomas in the intestinal tract




Genotype
MGI:2663872
hm2
Allelic
Composition		 Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lymphoma incidence ( J:34291 )
• lymphoma was observed in a single female at 6 months of age

reproductive system
azoospermia ( J:34291 )
• no spermatozoa in the epididymis
abnormal ovarian folliculogenesis ( J:34291 )
• decreased number of ovarian follicles
arrest of male meiosis ( J:34291 )
• arrest occuring at late pacytene, metaphase, or both
• premature separation of homologues, due to unsuccessful completion of recombination and chiasma formation

endocrine/exocrine glands
abnormal ovarian folliculogenesis ( J:34291 )
• decreased number of ovarian follicles

cellular
azoospermia ( J:34291 )
• no spermatozoa in the epididymis




Genotype
MGI:5688717
hm3
Allelic
Composition		 Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal chiasmata formation ( J:216866 )
• severely reduced chiasmata and accumulate univalent chromosomes in meiosis I




Genotype
MGI:3848460
cx4
Allelic
Composition		 Dnmt1tm1Jae/Dnmt1tm1Pwl
Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Jae mutation (2 available); any Dnmt1 mutation (108 available)
Dnmt1tm1Pwl mutation (0 available); any Dnmt1 mutation (108 available)
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:75745 )
• mice exhibit poorer survival than in Mlh1tm1Lisk homozygotes

neoplasm
neoplasm ( J:75745 )
N
• no mice develop intestinal tumors
increased lymphoma incidence ( J:75745 )
• 90% of mice develop lymphomas
• mice develop lymphomas at an earlier age than in Mlh1tm1Lisk homozygotes




Genotype
MGI:3848458
cx5
Allelic
Composition		 Dnmt1tm1Pwl/Dnmt1+
Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Pwl mutation (0 available); any Dnmt1 mutation (108 available)
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:75745 )
• mice exhibit reduced survival compared with wild-type mice

neoplasm
increased intestinal adenocarcinoma incidence ( J:75745 )
• 61% of mice develop intestinal tumors
increased intestinal adenoma incidence ( J:75745 )
• 61% of mice develop intestinal tumors
increased lymphoma incidence ( J:75745 )
• 29% of mice develop lymphomas
• mice develop lymphomas at an earlier age than in Mlh1tm1Lisk homozygotes

digestive/alimentary system
increased intestinal adenocarcinoma incidence ( J:75745 )
• 61% of mice develop intestinal tumors
increased intestinal adenoma incidence ( J:75745 )
• 61% of mice develop intestinal tumors




Genotype
MGI:3848459
cx6
Allelic
Composition		 Dnmt1tm1Jae/Dnmt1+
Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnmt1tm1Jae mutation (2 available); any Dnmt1 mutation (108 available)
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:75745 )
• mice exhibit poorer survival than in Mlh1tm1Lisk homozygotes

neoplasm
increased intestinal adenocarcinoma incidence ( J:75745 )
• 41% of mice develop intestinal tumors
increased intestinal adenoma incidence ( J:75745 )
• 41% of mice develop intestinal tumors
increased lymphoma incidence ( J:75745 )
• 56% of mice develop lymphomas
• mice develop lymphomas at an earlier age than in Mlh1tm1Lisk homozygotes

digestive/alimentary system
increased intestinal adenocarcinoma incidence ( J:75745 )
• 41% of mice develop intestinal tumors
increased intestinal adenoma incidence ( J:75745 )
• 41% of mice develop intestinal tumors




Genotype
MGI:5688722
cx7
Allelic
Composition		 Meikintm1Yow/Meikintm1Yow
Mlh1tm1Lisk/Mlh1tm1Lisk
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meikintm1Yow mutation (0 available); any Meikin mutation (18 available)
Mlh1tm1Lisk mutation (2 available); any Mlh1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal chromosomal synapsis ( J:216866 )
• univalents congressed at the metaphase plate and sister kinetochore pairs separated by >0.6 um are seen more frequently in oocytes from double mutant mice than in mutant mice wild-type for Meikin
• mono-orientation defect in spermatocytes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory